The minimum detectable dose of human SAP is typically less than 2.68 ng/mL. The Sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D. Value of 20 replicates of the zero calibrator plus three standard deviations.
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SH2D1A Antigen Profile
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
Alternative names and synonyms associated with SH2D1A
amyloid P component, serum (Apcs) ELISA Kit
SH2 domain containing 1A (SH2D1A) ELISA Kit
SH2 domain containing 1A (Sh2d1a) ELISA Kit
Sap ELISA Kit
DSHP ELISA Kit
EBVS ELISA Kit
IMD5 ELISA Kit
LYP ELISA Kit
MTCP1 ELISA Kit
SAP ELISA Kit
SAP/SH2D1A ELISA Kit
XLP ELISA Kit
XLPD ELISA Kit
RGD1562408 ELISA Kit
Gm686 ELISA Kit
Protein level used designations for SH2D1A
serum amyloid P-component
, Duncan disease SH2-protein
, SH2 domain-containing protein 1A
, SLAM associated protein/SH2 domain protein 1A
, SLAM-associated protein
, T cell signal transduction molecule SAP
, T-cell signal transduction molecule SAP
, signaling lymphocyte activation molecule-associated protein
, signaling lymphocytic activation molecule-associated protein
, SH2 domain protein 1A
, Duncan disease homolog