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Human Polyclonal ABCB4 Primary Antibody for IHC (p), WB - ABIN390060
Ruetz, Gros: Phosphatidylcholine translocase: a physiological role for the mdr2 gene. in Cell 1994
Show all 2 Pubmed References
FIC1 (show ATP8B1 Antibodies), BSEP (show ABCB11 Antibodies), and MDR3 represent hepatobiliary transport proteins essential for bile formation.
reduced ABCB4 expression predisposes to extrahepatic biliary atresia
The functional impact of ABCB4 mutations found in progressive familial intrahepatic cholestasis type 3.
Several members of a family exhibited cholestasis and were found to have a substitution of glycine 68 by arginine in ABCB4 due to a missense mutation at base 202. The 18-year-old propositus was heterozygous for this mutation and also suffered acute pancreatitis.
ABCB4 variants identified in patients with biliary diseases
results are suggestive of a potential downstream molecular effect for the described polymorphisms on the expression pattern of the ABCB4 underlining the importance of synonymous variants
the first characterisation at the protein level of six ABCB4 variants (D243A, K435T, G535D, I490T, R545C, and S978P) previously found in patients with inflammatory liver diseases or liver cancer, is reported.
Ivacaftor is a potential therapy for selected patients with cystic fibrosis (show S100A8 Antibodies) with mutations of ABCB4.
Data show that patients with low multidrug resistance protein 3 (MDR3) expression were significantly associated with a better outcome than patients with high MDR3 expression.
In patients with intrahepatic cholestasis of pregnancy, ABCB4 gene mutation was not associated with response to ursodeoxycholic acid treatment.
These results provide evidence that zebrafish Pxr (show NR1I2 Antibodies) may play a role in MDR/MXR through transcriptional regulation of abcb4 and cyp3a65 gene expression.
Zebrafish Abcb4 plays crucial roles in cellular efflux of microcystin-LR and is a potential molecular marker for the monitoring of cyanobacteria contamination in the aquatic environment.
A panel of 18 P-gp substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp can affect the pulmonary kinetics of a subset of P-gp substrates.
The results of this study suggested suggest that THC exposure decreased the neurobehavioral effects of risperidone because of P-gp upregulation in the brain.
The results show that the absence of P-gp results in a significant disturbance of Abeta (show APP Antibodies) removal from the brain and increased intraparenchymal cerebral amyloid angiopathy after immunization against Beta-Amyloid.
These data confirm that seliciclib displays a limited brain exposure and Abcb1a is at least partly responsible for limited brain exposure of seliciclib in mice.
Data suggest that, in the presence of verapamil (a substrate that activates ATP hydrolysis), the nucleotide-binding domains of Abcb1a (reconstituted in lipid bilayer nanodiscs) are never far apart during cycle of ATP hydrolysis.
MDR1A deficiency restrains tumor growth in murine colitis-associated carcinogenesis.
multiple pathways, including MMP9 (show MMP9 Antibodies) cleavage and ubiquitinylation, mediated P-gp downmodulation.
Data suggest that MDR3 isoforms, both human and mouse isoforms, exhibit different affinities for fluorescent dyes and drugs; thus, ligands likely occupy partially overlapping but distinct binding sites.
using double electron-electron resonance and molecular dynamics simulations to describe the ATP- and substrate-coupled conformational cycle of the mouse ABC (show ABCB6 Antibodies) efflux transporter P-glycoprotein (Pgp; also known as ABCB1 (show ABCB1 Antibodies))
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined\; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.
ATP-binding cassette sub-family B member 4
, P glycoprotein 3/multiple drug resistance 3
, P-glycoprotein 3
, P-glycoprotein-3/multiple drug resistance-3
, multidrug resistance protein 3
, multiple drug resistance 3
, ABC efflux transporter 4
, multidrug resistance 3
, ATP-binding cassette, subfamily B, member 4
, P glycoprotein 2
, multidrug resistance protein 2
, ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2
, ATP-binding cassette sub-family B (MDR/TAP) member 4 (P-glycoprotein 3/ multidrug resistance 2)
, ATP-binding cassette, sub-family B (MDR/TAP), member 4 (P-glycoprotein 3/ multidrug resistance 2)
, P-glycoprotein 2
, P-glycoprotein 3/ multidrug resistance 2
, ATP-binding cassette, sub-family B (MDR/TAP), member 4
, multidrug resistance protein 3-like
, ATP-binding cassette transporter protein
, ATP-binding cassette sub-family B member 1A
, ATP-binding cassette, subfamily B, member 1A
, P glycoprotein 3
, ecotropic viral integration site 32
, multi-drug resistance 3
, multidrug resistance protein 1A
, multiple drug resistant 1a
, Beta-defensin 1
, Defensin, beta 1
, p-glycoprotein isoform III
, LOW QUALITY PROTEIN: phosphatidylcholine translocator ABCB4
, RUN domain containing 3B
, RUN domain-containing protein 3B
, phosphatidylcholine translocator ABCB4
, P glycoprotein 3/ multiple drug resistance 3