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A novel transcriptional repression mechanism of hMED18 mediated by hCDK8 and further a novel positive role of free CDK/cyclin module in transcriptional activation is described.
MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003
mediator complex subunit 18
, mediator of RNA polymerase II transcription, subunit 18 homolog
, mediator of RNA polymerase II transcription subunit 18
, TRAP/mediator complex subunit p28b