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Data indicate that specific cancer-driving nodes are generally under NF-YA (show NFYA Proteins)/B control.
NF-YB transcription factor was identified as a novel direct E2F1 (show E2F1 Proteins) target.
The NF-Y complex is asymmetric, with NF-YB binding approximately 15 bp downstream from the CCAAT motif.
The crystal structure of NF-Y bound to a 25 bp CCAAT oligonucleotide shows that the histone-fold domains dimer binds to the DNA sugar-phosphate backbone, mimicking the nucleosome H2A/H2B-DNA assembly; NF-YA (show NFYA Proteins) both binds to NF-YB/NF-YC (show NFYC Proteins) and inserts an alpha helix deeply into the DNA minor groove, providing sequence-specific contacts to the CCAAT box.
Transcriptional repression mediated by IER5 (show IER5 Proteins) regulates Cdc25B (show CDC25B Proteins) expression levels via the release of NF-YB and p300 (show EP300 Proteins) in acute myeloid leukemia (show BCL11A Proteins).
NF-Y acts upstream of H3K4me3 deposition by recruiting Ash2L (show ASH2L Proteins)
The NF-YB/NF-YC (show NFYC Proteins) structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y.
p300 (show EP300 Proteins) binds to multiple NF-Y trimers to regulate cyclin B2 (show CCNB2 Proteins) promoter function
CBF/NF-Y proteins regulate the transcription of COL11A1 (show COL11A1 Proteins) by directly binding to the ATTGG sequence in the proximal promoter region
Histone deacetylase (show HDAC1 Proteins) inhibitors can induce Gadd45 (show GADD45A Proteins) through its promoter without the need for functional p53 (show TP53 Proteins), and both Oct-1 (show POU2F1 Proteins) and NF-Y concertedly participate in trichostatin A-induced activation of the gadd45 (show GADD45A Proteins) promoter.
results exclude NFYB as candidate gene for congenital splay leg but provide a basis for selection of further candidates for the disease from SSC5
deletion of CBF-B (show NFYA Proteins) activated expression of specific endoplasmic reticulum stress-regulated genes. Inactivation of CBF-B (show NFYA Proteins) also inhibited expression of C/EBP alpha (show CEBPA Proteins), an important transcription factor controlling metabolic processes in adult hepatocytes
p73 (show ARHGAP24 Proteins) and DeltaNp73 behave as physiological regulators for recruitment of histone deacetylase (show HDAC1 Proteins) to NF-Y and transcription of the PDGFRB (show PDGFRB Proteins) promoter
CBF-A (show CEBPA Proteins) is a novel transacting factor required for cytoplasmic mRNA transport and localization
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence\; protein sequence alignments and experiments with mutants.
nuclear transcription factor Y, beta
, nuclear transcription factor Y subunit beta
, CAAT box DNA-binding protein subunit B
, CCAAT-binding transcription factor subunit A
, Transcription factor NF-Y, B subunit
, nuclear transcription factor Y subunit B
, nuclear Y/CCAAT-box binding factor B subunit NF-YB
, CAAT-box DNA binding protein subunit B (NF-YB)
, CAAT-box DNA-binding protein subunit B
, nuclear transcription factor Y beta
, CCAAT binding transcription factor of CBF-B/NFY-B
, nuclear transcription factor - Y beta