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Aggregate genetic variation in circadian rhythm and melatonin pathways were significantly associated with the risk of prostate cancer in data combining GAME-ON and PLCO, after Bonferroni correction (ppathway < 0.00625). The two most significant genes were NPAS2 (pgene = 0.0062) and AANAT (show AANAT Proteins) (pgene = 0.00078); the latter being significant after Bonferroni correction.
Significantly, this study is the first to show that a variant copy number GGC (show GGCT Proteins) repeat sequence in the NPAS2 clock gene associates with melanoma risk and which may be useful in the assessment of melanoma predisposition.
CLOCK, ARNTL (show ARNTL Proteins), and NPAS2 gene polymorphisms may have a role in seasonal variations in mood and behavior
Genetic variations in NPAS2 might be a biomarker for a seasonal pattern in bipolar disorders.
With whole-exome sequencing a novel mutation in NPAS2 was identified in a Turkish family with nonobstructive azoospermia.
NPAS2 rs2305160 polymorphism does not appear to have any association with risk of chronic lymphocytic leukemia in our Pakistani population.
distributions of allelic, genotypic, and haplotypic variants of NPAS2 (rs2305160 and rs6725296) were not significantly different between schizophrenic patients with and without RLS
Two single nucleotide polymorphisms in RORA (show RORA Proteins) were associated with breast cancer in the whole sample and among postmenopausal women, and we also reported an association with CLOCK, RORA (show RORA Proteins), and NPAS2 in the analyses at the gene level
Functional rs1053096 and rs2305160 polymorphisms in the NPAS2 gene are associated with overall survival in transcatheter arterial chemoembolization-treated hepatocellular carcinoma patients.
NPAS2, functioned as a potential tumor suppressor gene, could serve as a promising target and potential prognostic indicator for colorectal cancer.
Here we have provided an initial key insight into the interplay between neonatal establishment of the peripheral circadian clock in the liver and the ability of the gut (show GUSB Proteins) microbiome to respond to dietary and metabolic stress.
In CLOCK-deficient fibroblasts, knockdown of Npas2 leads to arrhythmicity, suggesting that NPAS2 can compensate for loss of CLOCK in peripheral cells as well as in suprachiasmatic nucleus.
Study identified a unique role for Npas2 in the regulation of cocaine reward and dopamine Drd3 (show DRD3 Proteins) receptor expression
In the absence of NADPH (show FDXR Proteins), a change in pH from 6.5 to 8.0 decreased the KD(app (show APP Proteins)) value of the E-box from 125 to 22 nM, with an 8-fold increase in the maximal level of DNA binding for the NPAS2/BMAL1 (show ARNTL Proteins) heterodimer.
Shp (show LAMC1 Proteins) and Npas2 crosstalk is essential to maintain hepatic lipid homeostasis.
Dysregulation of Npas2 leads to altered metabolic pathways in a murine knockout model.
BMAL1 (show ARNTL Proteins) in a complex with CLOCK or NPAS2 regulates cerebral redox homeostasis and connects impaired clock gene function to neurodegeneration.
Npas2 shows circadian expression in retinal ganglion cells in mice.And Contrast sensitivity is similarly reduced in Npas2-/- mice.
NPAS2 containing the N-terminal 61 residues forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like (show ARNTL Proteins) protein (BMAL1 (show ARNTL Proteins)) to bind DNA; NAD(P)H (show NQO1 Proteins) enhances the binding activity.
DNA-binding of NPAS2 and BMAL1 (show ARNTL Proteins) to Per2 (show PER2 Proteins) was also decreased by SD, although SD is known to increase Per2 (show PER2 Proteins) expression in the cortex. DNA-binding to Per1 (show PER1 Proteins) and Cry1 (show CRY1 Proteins) was not affected by SD
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain.
neuronal PAS domain protein 2
, neuronal PAS domain-containing protein 2-like
, bHLH-PAS clock protein
, bHLH-PAS transcription factor MOP4
, member of PAS protein 4
, neuronal PAS domain-containing protein 2
, neuronal PAS2
, PAS domain-containing protein 4
, basic-helix-loop-helix-PAS protein MOP4
, class E basic helix-loop-helix protein 9
, member of PAS superfamily 4