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Data show that the combination of GATA binding protein 4 (Gata4 (show GATA4 Proteins)), T-box transcription factor 5 (Tbx5 (show TBX5 Proteins)) and BRG1-associated factor 60C protein (Baf60c) is sufficient for inducing adipose tissue-derived mesenchymal stem cells (ADMSCs) to form cardiomyocytes.
Inhibition of Wnt5a (show WNT5A Proteins) by either RNAi knockdown or blocking antibody reversed Smarcd3 -induced epithelial-mesenchymal transition. Thus, Smarcd3 epigenetically regulates epithelial-mesenchymal transition by activating WNT (show WNT2 Proteins) signaling pathways.
Deptor (show DEPTOR Proteins) is induced by the Baf60c-Six4 (show SIX4 Proteins) transcriptional complex and mediates activation of Akt (show AKT1 Proteins) and glycolytic metabolism by Baf60c in a cell-autonomous manner
BAF60c promotes lipogenesis in vivo and increases triglyceride levels, demonstrating its role in metabolic adaption to activate the lipogenic program in response to feeding and insulin (show INS Proteins).
Data show a combination of only five genes (-BCL6 (show BCL6 Proteins), T (BRACHYURY (show TBX1 Proteins)), c-MYC (show MYC Proteins), MITF (show MITF Proteins) and BAF60C (SMARCD3) rapidly and efficiently convert postnatal chorion and decidual cells into chondrocytes.
BAF6 (show MYOD1 Proteins)0c phosphory (show SMARCA1 Proteins)lati (show SNRPA Proteins)on on a conserved threonine is the signal that promotes inc (show MYOD1 Proteins)orporation of MyoD-BAF60c into a Brg1-based SWI/SNF complex, which remodels the chromatin & activates transcription of MyoD-target genes.
GTNB (show DTNB Proteins) directs cardiogenesis from human embryonic stem cells and induces correct cardiac development.
BAF60c represents a new coregulator that constitutes an important anchoring point by which the SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) complex is recruited to nuclear receptors and other transcription factors
Tat (show TAT Proteins)-mediated activation of the HIV promoter requires the SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) complex in synergy with the coactivator p300 (show EP300 Proteins).
Baf60c is re-expressed in the Muller glial cells that re-enter the cell cycle after neurotoxic damage
work revealed functional redundancy between Baf60a (show SMARCD1 Proteins) and Baf60c in maintaining oxidative and glycolytic metabolism in skeletal myofibers and exercise endurance. Unexpectedly, mice lacking these two factors in skeletal muscle were protected from diet-induced and age-associated metabolic disorders. Transcriptional profiling analysis identified the muscle thermogenic gene program and myokine secretion as key pathways that inte
These data suggested that Baf60c plays an important role in cardiomyocyte proliferation in heart development and regeneration. This is the first study indicating that Baf60c contributes to the heart regeneration in vertebrates.
postmitotic expression SOD1G93A mutant gene promotes a FAPS phenotype in C2C12 cells, by upregulating HDAC4 (show HDAC5 Proteins) protein and preventing the BAF60C-SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) complex myogenic commitment
regulates the Nodal/Bone Morphogenetic Protein antagonist Cerberus (show CER1 Proteins) and the Baf60c/Smarcd3 subunit of the Brg1 (show SMARCA4 Proteins)/Brm (show SMARCA2 Proteins)-associated factors (BAF (show BANF1 Proteins)) chromatin-remodelling complex
Overexpression of transcription factors MYOCD and SRF alone or in conjunction with Mesp1 (show MESP1 Proteins) and SMARCD3 enhanced the basal but necessary cardio-inducing effect of the previously reported GATA4 (show GATA4 Proteins), TBX5 (show TBX5 Proteins), and MEF2C (show MEF2C Proteins).
MyoD (show MYOD1 Proteins) and the SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) subunit BAF60c interact on the regulatory elements of MyoD (show MYOD1 Proteins)-target genes in myoblasts, prior to activation of transcription.
Smarcd3, encoding Baf60c, a subunit of the BAF (show BANF1 Proteins) complexes, is expressed specifically in the heart and somites in the early mouse embryo
propose a critical role for Baf60c in Notch (show NOTCH1 Proteins)-dependent transcription and left-right asymmetry
Two highly related subunits of the core SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) complex, BAF60c1 and BAF60c2, interact physically with retinoid receptors and are coactivators for retinoic acid receptors.
Smarcd3 regulates the timing of zebrafish myogenesis onset [Smarcd3]
Overexpression of smarcd3b and gata5 in zebrafish results in an enlarged heart, whereas combinatorial loss of cBAF components inhibits cardiac differentiation, demonstrating that Smarcd3b and Gata5 can induce a primitive, progenitor cell-like state.
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3-like
, 60 kDa BRG-1/Brm-associated factor subunit C
, BRG1-associated factor 60C
, SWI/SNF complex 60 kDa subunit C
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3
, Swp73-like protein
, chromatin remodeling complex BAF60C subunit
, mammalian chromatin remodeling complex BRG1-associated factor 60C