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anti-Human TXNRD1 Antibodies:
anti-Rat (Rattus) TXNRD1 Antibodies:
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Human Polyclonal TXNRD1 Primary Antibody for ELISA, WB - ABIN268642
Gasdaska, Gasdaska, Cochran, Powis: Cloning and sequencing of a human thioredoxin reductase. in FEBS letters 1995
Human Polyclonal TXNRD1 Primary Antibody for IF (p), IHC (p) - ABIN1386102
Kaya, Çiçek, Erdi, Findik, Karatas, Esen, Keskin, Kalkan: Intratumoral hemorrhage-related differences in the expression of vascular endothelial growth factor, basic fibroblast growth factor and thioredoxin reductase 1 in human glioblastoma. in Molecular and clinical oncology 2016
NTRC plays a pivotal role in chloroplast redox regulation, being necessary for the activity of diverse thioredoxins with unrelated functions.
NTRC-mediated regulation of the Calvin-Benson cycle and ATP synthesis occurs both directly and through interaction with the ferredoxin-thioredoxin (show TXN Antibodies) system and is crucial when availability of light is limiting photosynthesis.
NTRC is highly sensitive to rapidly changing light intensities.NTRC is not responsible for 'metabolism-related' regulation of the ATP synthase.
cooperative control of chloroplast functions via the FTR/Trx (show TXN Antibodies) and NTRC pathways is essential for plant viability
These data uncover a new role for NTRC in the control of photosynthetic yield.
An Arabidopsis thaliana double knockout mutant lacking NTRC and Srx (show SRX1 Antibodies) shows a phenotype similar to the ntrc mutant, while the srx (show SRX1 Antibodies) mutant resembles wild-type plants. NTRC deficiency causes reduced overoxidation of 2-Cys (show DNAJC5 Antibodies) peroxiredoxins.
NADPH thioredoxin reductase C is involved in redox regulation of the Mg-chelatase I subunit in Arabidopsis thaliana chloroplasts
interaction of chloroplast 2-Cys (show DNAJC5 Antibodies) peroxiredoxin with NADPH (show NQO1 Antibodies)-thioredoxin reductase C (NTRC) and thioredoxin (show TXN Antibodies) x
The strongest reduction in ntrc growth occurred under photoperiods with nights longer than 14 h, whereas knockout of the NTRC gene did not alter the circadian-clock-controlled growth. Lack of NTRC modulated chloroplast reactive oxygen species metabolism.
heat shock-mediated holdase chaperone function of NTRC is responsible for the increased thermotolerance of Arabidopsis and the activity is significantly supported by NADPH
Selenoprotein TRXR-1 and GSR-1 (show GSR Antibodies) are essential for removal of old cuticle during molting in Caenorhabditis elegans.
Mechanistic study uncovers for the first time that the selenoprotein thioredoxin reductase (TrxR) is one of the targets by which PL-CL promotes the ROS generation
Endogenous TrxR1 is sensitive to nitrosylation-dependent inactivation.
This study thus provides novel insights into the catalytic mechanisms of TrxR1. One-electron juglone reduction by TrxR1 producing superoxide should furthermore contribute to the well-known prooxidant cytotoxicity of juglone
Mutation of TXNRD1 was identified in a family with genetic generalized epilepsy.
Data show that small molecule B19 targets and inactivates thioredoxin reductase 1 (TrxR1) in gastric cancer cells.
Analysis of 25 independent cohorts with 5910 patients showed that Trx1 (show MLL Antibodies) and TrxR1 were both associated with a poor patient prognosis in terms of overall survival, distant metastasis free survival and disease free survival.
High TRXR1 expression is associated with oral squamous cell carcinoma.
Inhibition of thioredoxin reductase-1 by brevetoxin-2 is via the formation of a Michael adduct between selenocysteine and the alpha, beta-unsaturated aldehyde moiety of the toxin.
Here, the authors use a novel assay to demonstrate that the reduction in non-native disulfides requires NADPH (show NQO1 Antibodies) as the ultimate electron donor, and a robust cytosolic thioredoxin (show TXN Antibodies) system, driven by thioredoxin reductase 1 (TrxR1 or TXNRD1).
Taken together, these findings indicate that auranofin inhibition of TrxR activity in Hep3B cells activates ROS (show ROS1 Antibodies)- and caspase (show CASP3 Antibodies)-dependent apoptotic signaling pathways and triggers cancer cell death.
The developmental expression of cytosolic glutathione peroxidase (show GPX1 Antibodies) and TRXR1 during fetal development and the effect of maternal selenium consumption on the expression of these proteins are reported.
regenerated coronary endothelial cells exhibit downregulation of thioredoxin reductase
These results suggest that thioredoxin reductase (show PRDX5 Antibodies) may act as a positive regulator of NF-kappa B (show NFKB1 Antibodies) and may play an important role in the cellular inflammatory response.
data provide evidence for the involvement of the Trx/TrxR (show GSR Antibodies) system, in the regulation of haem oxygenase-1 expression in aortic endothelial cells during pro-oxidant challenge
GSR (show GSR Antibodies) is not essential for the maintenance of antioxidant defenses in mouse cochlea; the thioredoxin/thioredoxin (show TXN Antibodies) reductase (show PRDX2 Antibodies) system can probably operate as a functional backup for GSR (show GSR Antibodies).
TrxR1 represents a novel therapeutic target to prevent oxygen-mediated neonatal lung injury through Nrf2 (show NFE2L2 Antibodies).
The results demonstrate that DATS protects against oxidative stress-induced (show SQSTM1 Antibodies) DNA damage and apoptosis in C2C12 cells in part through the activation of Nrf2 (show NFE2L2 Antibodies)-mediated TrxR1 induction via the ERK (show EPHB2 Antibodies) signaling pathway.
Collectively, our results suggest that MsrA (show MSR1 Antibodies) protects hepatocytes from APAP-induced cytotoxicity through the modulation of TXNRD1 expression.
the timely upregulation of Trx1 (show TXN Antibodies)/TrxR1 and the active control of intracellular redox status is critical for the survival of thymocytes during and short after positive selection.
Considering the variable expression levels of Sep15 (show SEP15 Antibodies) and TR1 found within the human population, our results provide insights into new roles of selenoproteins in cancer
Data suggest TXNRD1 and TXRNRD2 function at the top of a redox pyramid that governs the oxidation state of peroxiredoxins and other protein factors, thereby dictating a hierarchy of phenotypic responses to oxidative insults.
Augmentation of GSH systems by TrxR1 inhibition could represent a promising therapeutic approach to attenuate oxidant-mediated lung injury and improve patient outcomes.
Because the N-terminal domain of Sepp1 (show SEPP1 Antibodies) has a thioredoxin (show TXN Antibodies) fold, Sepp1 (show SEPP1 Antibodies)(UF) were compared with full-length Sepp1 (show SEPP1 Antibodies), Sepp1 (show SEPP1 Antibodies)(Delta240-361), and Sepp1 (show SEPP1 Antibodies)(U40S) as a substrate of thioredoxin reductase-1 (TrxR1).
Sec-containing TrxR1 is absolutely required for self-sufficient growth of MEFs under high-glucose conditions, owing to an essential importance of this enzyme for elimination of glucose-derived H2O2.
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.
thioredoxin reductase 1, cytoplasmic
, thioredoxin reductase 3
, thioredoxin reductase 1
, thioredoxin reductase 1, cytoplasmic-like
, KM-102-derived reductase-like factor
, gene associated with retinoic and IFN-induced mortality 12 protein
, gene associated with retinoic and interferon-induced mortality 12 protein
, thioredoxin reductase GRIM-12
, thioredoxin reductase TR1
, redox enzyme thioredoxin reductase
, NADPH-dependent thioredoxin reductase
, selenoprotein oxidoreductase
, TR alpha