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anti-Human EPC1 Antibodies:
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Human Polyclonal EPC1 Primary Antibody for WB - ABIN1881300
Shimono, Murakami, Hasegawa, Takahashi: RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions. in The Journal of biological chemistry 2001
Show all 3 Pubmed References
Epigenetic factor EPC1 (show SERPINF1 Antibodies) is a master regulator of DNA damage response by interacting with E2F1 (show E2F1 Antibodies) to silence death and activate metastasis-related gene signatures
Silencing EPC1 (show SERPINF1 Antibodies) by short hairpin RNA technology had the inhibition effects on cell proliferation and tumor growth in lung cancer
EPC1 (show SERPINF1 Antibodies) and EPC2 (show EPC2 Antibodies) are components of a complex that directly or indirectly serves to prevent MYC (show MYC Antibodies) accumulation and AML (show RUNX1 Antibodies) cell apoptosis, thus sustaining oncogenic potential
Epc1 (show SERPINF1 Antibodies) plays a role in the initiation of skeletal muscle differentiation, and its interaction with Hop (show STIP1 Antibodies) is required for the full activity.
SNP array CGH analysis of the breakpoint region in 3 ATLL-related cell lines and 4 patient samples revealed the chromosomal breakpoints are localized within the EPC1 (show SERPINF1 Antibodies) gene locus in an ATLL-derived cell line (SO4) and in one patient with acute-type ATLL.
Results report that EPC1 and TIP60 (show KAT5 Antibodies) are co-expressed in male germ cells. Genetic ablation of either Epc1 or Tip60 (show KAT5 Antibodies) disrupts hyperacetylation and impairs histone replacement, in turn causing aberrant spermatid development.
results indicate that Epc1 induces vascular smooth muscle differentiation by interacting with myocardin (show MYOCD Antibodies) to induce serum response factor-dependent smooth muscle genes; propose that Epc1 acts as a novel negative regulator of neointima formation after carotid injury
Epc1-induced enhancements of SRF-dependent multinucleation, transactivation of the skeletal alpha-actin (show ACTA1 Antibodies) promoter, binding of SRF to the serum response element, and muscle-specific (show EIF3K Antibodies) gene induction were blocked by RFP (show RFP Antibodies).
showed that E2F6 (show E2F6 Antibodies), DP1 (show REEP5 Antibodies), EPC1, EZH2 (show EZH2 Antibodies), and Sin3B (show SIN3B Antibodies) co-elute, suggesting the identification of a novel E2F6 (show E2F6 Antibodies) complex that exists in vivo in both normal and transformed human cell lines
Epc1 plays a role in the initiation of skeletal muscle differentiation, and its interaction with Hop (show STIP1 Antibodies) is required for the full activity.
Epc1 is required for skeletal muscle differentiation by recruiting both SRF and p300 (show NOTCH1 Antibodies) to the SRE of muscle-specific (show EIF3K Antibodies) gene promoters
This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants.
enhancer of polycomb homolog 1 (Drosophila)
, enhancer of polycomb 1
, enhancer of polycomb homolog 1
, enhancer of polycomb homolog 1-like
, enhancer of polycomb homolog 1 L homeolog