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anti-Human Foxo6 Antibodies:
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High FOXO6 expression is associated with gastric cancer.
this study established a correlation between FOXO6 expression and gastric cancer prognosis. FOXO6 could be a promising predictor for prognosis in gastric cancer.
Lacking the FOXO6 risk allele was associated with an increase in negative schizophrenia symptoms and surface area reduction in the right orbitofrontal gyrus - an area previously associated with negative symptoms - suggesting that presence of the FOXO6 risk allele confers resistance against negative symptoms and associated neuroanatomical changes in individuals with first-episode schizophrenia.
In conclusion, the results of the present study indicated that the FOXO6/USP7 molecular network has an important role in the regulation of lung cancer development.
Studies indicate that FoxO6 is produced in the liver of both rodents and humans.
FOXO6 induces C-myc expression by associating to HNF4 and mediating histone acetylation, and the dissociation of HDAC3 from the promoter of the C-myc gene
Studies indictet that the mammalian FoxO family consists of FoxO1, 3, 4 and 6 and are regulated by by AKT and 14-3-3 proteins.
investigation of role of FoxO6 in liver: Data suggest that a FoxO6-dependent pathway in hepatocytes orchestrates insulin regulation of gluconeogenesis.
gene study of FOXO6, reveals no association with human longevity in Germans
cloning and characterization; structural and functional properties related to gene regulation
data indicate that FoxO6 depletion protected against diet-induced glucose intolerance and insulin resistance by attenuating hepatic gluconeogenesis and curbing macrophage infiltration in liver and adipose tissues in mice.
FoxO6 is an important signaling molecule upstream of MTP for regulating hepatic VLDL-TG production
FoxO6 represses the expression of PGC-1alpha via direct binding to an upstream A/T-rich element (AAGATATCAAAACA,-2228-2215) in the PGC-1alpha promoter.
FoxO6 regulates a program of genes involved in synaptic function upon learning in the hippocampus
Central FoxO3a and FoxO6 expression is down-regulated in obesity induced diabetes but not in aging.
investigation of role of FoxO6 in liver: Data suggest that a FoxO6-dependent pathway in liver orchestrates insulin regulation of gluconeogenesis. FoxO6 appears to be ubiquitously expressed in mouse tissues.
FoxO factors mediate Myc-induced Arf expression and provide direct genetic evidence for their tumor-suppressive capacity.
forkhead box O6
, forkhead box O3
, forkhead box O3-like
, forkhead box protein O6