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this study established a correlation between FOXO6 expression and gastric cancer prognosis. FOXO6 could be a promising predictor for prognosis in gastric cancer.
Lacking the FOXO6 risk allele was associated with an increase in negative schizophrenia symptoms and surface area reduction in the right orbitofrontal gyrus - an area previously associated with negative symptoms - suggesting that presence of the FOXO6 risk allele confers resistance against negative symptoms and associated neuroanatomical changes in individuals with first-episode schizophrenia.
In conclusion, the results of the present study indicated that the FOXO6/USP7 (show USP7 Proteins) molecular network has an important role in the regulation of lung cancer development.
Studies indicate that FoxO6 is produced in the liver of both rodents and humans.
FOXO6 induces C-myc (show MYC Proteins) expression by associating to HNF4 (show HNF4A Proteins) and mediating histone acetylation, and the dissociation of HDAC3 (show HDAC3 Proteins) from the promoter of the C-myc (show MYC Proteins) gene
Studies indictet that the mammalian FoxO (show FOXO3 Proteins) family consists of FoxO1 (show FOXO1 Proteins), 3, 4 and 6 and are regulated by by AKT (show AKT1 Proteins) and 14-3-3 (show YWHAQ Proteins) proteins.
investigation of role of FoxO6 in liver: Data suggest that a FoxO6-dependent pathway in hepatocytes orchestrates i (show INS Proteins)nsulin regulation of gluconeogenesis.
gene study of FOXO6, reveals no association with human longevity in Germans
data indicate that FoxO6 depletion protected against diet-induced glucose intolerance and insulin (show INS Proteins) resistance by attenuating hepatic gluconeogenesis and curbing macrophage infiltration in liver and adipose tissues in mice.
FoxO6 is an important signaling molecule upstream of MTP (show LAPTM4A Proteins) for regulating hepatic VLDL-TG production
FoxO6 represses the expression of PGC-1alpha via direct binding to an upstream A/T-rich element (AAGATATCAAAACA,-2228-2215) in the PGC-1alpha promoter.
FoxO6 regulates a program of genes involved in synaptic function upon learning in the hippocampus
Central FoxO3a (show FOXO3 Proteins) and FoxO6 expression is down-regulated in obesity induced diabetes but not in aging.
investigation of role of FoxO6 in liver: Data suggest that a FoxO6-dependent pathway in liver orchestrates insulin (show INS Proteins) regulation of gluconeogenesis. FoxO6 appears to be ubiquitously expressed in mouse tissues.
FoxO factors mediate Myc-induced Arf expression and provide direct genetic evidence for their tumor-suppressive capacity.
forkhead box O6
, forkhead box O3
, forkhead box O3-like
, forkhead box protein O6