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BLIMP1 (PRDM1)expression begins throughout the hypoblast at stage 1 and emerges in single primordial germ cell (PGC (show PGC Proteins)) precursors in the posterior epiblast at stage 2.
The timing of shade expression is determined by its transcriptional activator betaFtz-f1. The betaftz-f1 gene is activated after a decline in the expression of its transcriptional repressor Blimp-1.
Blimp-1 gene is transcribed during prepupal development when the ecdysteroid titer is high, but the expressed mRNA degrades rapidly.
Blimp-1 regulates terminal differentiation of the tracheal system in the Drosophila embryo.
These results suggest that the transient transcriptional repressor dBlimp-1 is important for determining developmental timing in the ecdysone-induced pathway.
Expression of the M- and N-cadherins, previously implicated in driving adaxial cell migration, is largely unaffected by loss of Prdm1a function, suggesting that differential cadherin expression is not sufficient for adaxial cell migration
Prdm1a functions as both a transcriptional activator and repressor during neural crest development.
identify sox6 cis (show CISH Proteins)-regulatory sequences that drive fast-twitch-specific expression in a Prdm1a-dependent manner
prdm1a expression is upregulated in the absence of Notch (show NOTCH1 Proteins) function, and inhibiting Notch (show NOTCH1 Proteins) signaling fails to rescue prdm1a mutants
prdm1a Regulates sox10 (show SOX10 Proteins) and islet1 (show ISL1 Proteins) in the development of neural crest and Rohon-Beard sensory neurons.
These results indicate an essential role for prdm1a in the development of the zebrafish craniofacial skeleton.
Here we show that the gene u-boot (ubo), a mutation in which disrupts the induction of embryonic slow-twitch fibers, encodes the zebrafish homolog of Blimp-1
The transcriptional regulator Blimp-1 plays a role in the inception of Neural Crest progenitor fate through BMP signalling.
prdm1/blimp1 has roles in embryo patterning and organogenesis
prdm1 functions to promote the cell fate specification of both neural crest cells and sensory neurons
The authors herein prove, for the first time, that the transcriptional repressor Blimp1 is a novel mediator of p130Cas (show BCAR1 Proteins)/ErbB2 (show ERBB2 Proteins)-mediated invasiveness. Indeed, high Blimp1 expression levels are detected in invasive p130Cas (show BCAR1 Proteins)/ErbB2 (show ERBB2 Proteins) cells and correlate with metastatic status in human breast cancer patients.
Studied role of PR/SET domain 1 (PRDM1) protein in colon cancer; found that PRDM1beta acts as a tumor-suppressor gene in colon tumor organoids, probably by acting downstream of p53 (show TP53 Proteins). The study also shows It modifies the expression of stem cell related genes, inhibits colon epithelial cell proliferation, and is associated with good survival in colon cancer patients.
Data found that intratumoral hypoxia, which is an inevitable feature of advanced human pancreatic ductal adenocarcinoma, induces the expression of the pro-metastatic transcription factor Blimp1. The co-option of this master regulatory transcription factor is required for metastatic ability, and the molecular output of Blimp1 expression is the modulation of discrete hypoxia-induced gene expression programs.
Blimp1, Foxp1 (show FOXP1 Proteins) and pStat3 are expressed in extranodal diffuse large B-cell lymphomas
In conclusion, aberrant coexpression of MYC (show MYC Proteins) and PRDM1/Blimp1alpha owing to genetic changes is responsible for the phenotype of plasmablastic lymphoma cases.
Blimp-1 binds to the promoters of PD-1 (show PDCD1 Proteins) and TIGIT (show TIGIT Proteins) and positively regulates their expression in patients with acute myeloid leukemia (show BCL11A Proteins).
the promoter hypermethylation of PRDM1 harbored a predominant role in the downregulation of PRDM1 expression, significantly affecting the biological behavior of tumor cells in EN-NK/T-NT.
Blimp-1 suppresses the transcription of CUL4A (show CUL4A Proteins), resulting in the maintenance of the expression of Aiolos (show IKZF3 Proteins) and Ikaros (show IKZF1 Proteins).
HSP70 (show HSP70 Proteins)-Hrd1 (show SYVN1 Proteins) axis represents a potential therapeutic target for restoring the oncorepressor activity of unstable lymphoma-associated Blimp-1 mutants.
SOX2 (show SOX2 Proteins) repression in TCam-2 cells can be abrogated by recruitment of the constitutively expressed H3K27 demethylase (show MBD2 Proteins) UTX (show KDM6A Proteins) to the SOX2 (show SOX2 Proteins) promoter through retinoid signaling, leading to expression of neuronal and other lineage genes. SOX17 (show SOX17 Proteins) has been shown to initiate human PGC (show PGC Proteins) specification, with its target PRDM1 suppressing mesendodermal genes
B lymphocyte-induced maturation protein 1 (Blimp1) expression defines a mammary stem cell subpopulation with unique functional characteristics.
Blimp1-dependent transcripts are enriched in spiral artery trophoblast giant cells.
Moreover, the authors showed that Sirt6 (show SIRT6 Proteins), induced by RANKL (show TNFSF11 Proteins)-dependent NFATc1 (show NFATC1 Proteins) expression, forms a complex with B lymphocyte-induced maturation protein-1 (Blimp1) to negatively regulate expression of anti-osteoclastogenic gene such as Mafb (show MAFB Proteins).
Posterior PRDM1 contributes more broadly to the developing fetal-maternal connection than previously recognized, and PRDM1 and STELLA (show DPPA3 Proteins), while overlapping in putative primordial germ cells, also co-localize in several other tissues
Blimp1 deficiency resulted in reduced suppressive ability of Tfr (show TFRC Proteins) cells. This study identifies that Tfr (show TFRC Proteins) cells are potent suppressors of immunity and are controlled by Blimp1.
Data show that TLR4 (show TLR4 Proteins)-mediated up-regulation of Blimp-1 led to the down-regulation of NLRP12 (show NLRP12 Proteins) expression in dextran sulfate sodium (DSS (show PMP22 Proteins))-induced colitis.
Results established a molecular mechanism of TNF-a (show TNF Proteins)-induced osteoclasts differentiation, and provided insights into the potential contribution of Blimp1 in the regulation of osteoclastogenesis by TNF-a (show TNF Proteins).
results show that the intersection of three or more transcription factors is required to correctly regulate the spatial and temporal features of Blimp1 enhancer expression
findings show that Prdm1 acts independently of Aire (show AIRE Proteins), a crucial transcription factor implicated in medullary thymic epithelial cells function; data highlight a previously unrecognized role for Prdm1 in regulating thymic epithelial function
Prdm1 repressed expression of the gene encoding cathepsin S (Ctss (show CTSS Proteins)). Prdm1 deficiency in dendritic cells led to loss of appropriate regulation of Ctss (show CTSS Proteins) expression in female mice and thereby modulated antigen presentation and the follicular helper T cell repertoire to contribute to autoimmunity in lupus.
This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.
PR domain containing 1, with ZNF domain
, Blimp-1 protein
, B lymphocyte-induced maturation protein 1
, PR domain zinc finger protein 1
, PR domain-containing 1
, U boot
, B lymphocyte induced maturation protein 1
, PR domain zinc finger protein 1-like
, B-lymphocyte-induced maturation protein 1
, PRDI-binding factor-1
, beta-interferon gene positive-regulatory domain I binding factor
, B lymphocyte induced maturation protein
, PR domain containing 1 with ZNF domain
, PR domain-containing protein 1
, beta-interferon gene positive regulatory domain I-binding factor