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BLIMP1 (PRDM1)expression begins throughout the hypoblast at stage 1 and emerges in single primordial germ cell (PGC (show PGC Proteins)) precursors in the posterior epiblast at stage 2.
The timing of shade expression is determined by its transcriptional activator betaFtz-f1. The betaftz-f1 gene is activated after a decline in the expression of its transcriptional repressor Blimp-1.
Blimp-1 gene is transcribed during prepupal development when the ecdysteroid titer is high, but the expressed mRNA degrades rapidly.
Blimp-1 regulates terminal differentiation of the tracheal system in the Drosophila embryo.
These results suggest that the transient transcriptional repressor dBlimp-1 is important for determining developmental timing in the ecdysone-induced pathway.
Expression of the M- and N-cadherins, previously implicated in driving adaxial cell migration, is largely unaffected by loss of Prdm1a function, suggesting that differential cadherin expression is not sufficient for adaxial cell migration
Prdm1a functions as both a transcriptional activator and repressor during neural crest development.
identify sox6 cis (show CISH Proteins)-regulatory sequences that drive fast-twitch-specific expression in a Prdm1a-dependent manner
prdm1a expression is upregulated in the absence of Notch (show NOTCH1 Proteins) function, and inhibiting Notch (show NOTCH1 Proteins) signaling fails to rescue prdm1a mutants
prdm1a Regulates sox10 (show SOX10 Proteins) and islet1 (show ISL1 Proteins) in the development of neural crest and Rohon-Beard sensory neurons.
These results indicate an essential role for prdm1a in the development of the zebrafish craniofacial skeleton.
Here we show that the gene u-boot (ubo), a mutation in which disrupts the induction of embryonic slow-twitch fibers, encodes the zebrafish homolog of Blimp-1
The transcriptional regulator Blimp-1 plays a role in the inception of Neural Crest progenitor fate through BMP signalling.
prdm1/blimp1 has roles in embryo patterning and organogenesis
prdm1 functions to promote the cell fate specification of both neural crest cells and sensory neurons
The interaction between c-Maf (show MAF Proteins) and RORgammat, and Blimp-1.
these results provide novel clinical and biological insight into the tumor-suppressive role of PRDM1/BLIMP-1 in ABC (show ABCB6 Proteins)-DLBCL patients and suggest that loss of PRDM1/BLIMP-1 function contributes to the overall poor prognosis of ABC (show ABCB6 Proteins)-DLBCL patients.
PRDM1 was identified as a susceptibility gene for systemic sclerosis.
Data indicate that BTG2 (show BTG2 Proteins), MAP3K11 (show MAP3K11 Proteins), RPS6KA1 (show RPS6KA1 Proteins) and PRDM1 as putative targets of microRNA miR (show MLXIP Proteins)-125b.
we identified MIR155HG and TERC to be transcriptionally downregulated by PRDM1 in two PRDM1-null NK-cell lines when it is ectopically expressed. These findings suggest that ZFAS1 and other dysregulated long non-coding RNAs may be involved in natural killer/T-cell lymphoma pathobiology through regulation of cancer-related genes, and loss-of-PRDM1 expression in natural killer/T-cell lymphomas tumorigenesis
identified the Prdm1 gene encoding the B lymphocyte-induced maturation protein 1 as a crucial negative regulator of human TH17 cell differentiation
B cell receptor signaling component, SYK (show SYK Proteins), caused PAX5 (show PAX5 Proteins) tyrosine phosphorylation in vitro and in cells. Transcriptional repression on the BLIMP1 promoter by PAX5 (show PAX5 Proteins) was attenuated by this phosphorylation.
Depletion of PRDM1 in lung cancer cells promotes cellular invasion and anoikis resistance in vitro and lung metastasis in vivo.
Data show there was a positive correlation between B cell lymphoma 6 (Bcl-6 (show BCL6 Proteins)) and B lymphocyte-induced maturation protein 1 (Blimp-1) at the level of mRNA.
The PRDM1 expression appeared to play an essential role in Warthin tumour pathogenesis.
results show that the intersection of three or more transcription factors is required to correctly regulate the spatial and temporal features of Blimp1 enhancer expression
findings show that Prdm1 acts independently of Aire (show AIRE Proteins), a crucial transcription factor implicated in medullary thymic epithelial cells function; data highlight a previously unrecognized role for Prdm1 in regulating thymic epithelial function
Prdm1 repressed expression of the gene encoding cathepsin S (Ctss (show CTSS Proteins)). Prdm1 deficiency in dendritic cells led to loss of appropriate regulation of Ctss (show CTSS Proteins) expression in female mice and thereby modulated antigen presentation and the follicular helper T cell repertoire to contribute to autoimmunity in lupus.
Blimp1 is required to maintain a highly proliferative luminal subset necessary for mammary gland development and homeostasis.
Attenuated leptin-receptor (LEPR (show LEPR Proteins)) expression is essential for the development and maintenance of acute lymphoblastic leukemia (ALL), and that fasting inhibits ALL development by upregulation of LEPR (show LEPR Proteins) and its downstream signaling through the protein PR/SET domain 1 (PRDM1).
role of Blimp-1 as a critical regulator of CD4 (show CD4 Proteins) dysfunction and links it to the CD8 (show CD8A Proteins) T cell dysfunctionality observed in infected mice.
Contextual ablation of BLIMP-1 and p53 (show TP53 Proteins) led to development of IgM (show CD40LG Proteins)-positive B-cell lymphoma with an aggressive phenotype, supported by c-Myc (show MYC Proteins) up-regulation, and accumulation of somatic mutations, as demonstrated by whole exome sequencing.
this study shows that IL-10 (show IL10 Proteins) production during B-cell development is strongly correlated with the expression level of Prdm1
The escape of a fraction of Primordial germ cells from the Prdm1 deletion was sufficient to recover fairly normal germ cell pools, both in male and female adults
There is a common program of effector T cell differentiation that is regulated by IL-2 and IL-12 signaling and the combined activities of the transcriptional regulators Blimp-1 and T-bet.
This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.
PR domain containing 1, with ZNF domain
, Blimp-1 protein
, B lymphocyte-induced maturation protein 1
, PR domain zinc finger protein 1
, PR domain-containing 1
, U boot
, B lymphocyte induced maturation protein 1
, PR domain zinc finger protein 1-like
, B-lymphocyte-induced maturation protein 1
, PRDI-binding factor-1
, beta-interferon gene positive-regulatory domain I binding factor
, B lymphocyte induced maturation protein
, PR domain containing 1 with ZNF domain
, PR domain-containing protein 1
, beta-interferon gene positive regulatory domain I-binding factor