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anti-Human ZFHX3 Antibodies:
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The ZFHX3 SNP rs2106261 minor allele is associated with lower atrial fibrillation (AF) recurrence rate after pulmonary vein isolation. Low baseline inflammation conferred by this allele may reduce AF recurrence risk.
alterations in the expression and subcellular localization of ATBF1, as a result of posttranscriptional modifications, are associated with malignant features of colon tumours.
Study identified DNA methylation (DNAm) site cg07786668 in ZFHX3 that is independently and significantly associated with myocardial infarction (MI) along with DNAm cg17218495 in SMARCA4. These results suggest that the development of MI might be influenced by changes in DNAm at these sites via a pathway that differs from that affected by cardiovascular disease-associated SNPs in these genes.
using in vitro prolactin induced lactogenic differentiation in an HC11 mouse cell model and an in vivo conditional knockout mouse model we showed that mouse Zfhx3 is essential for mouse mammary epithelial cell differentiation and mouse mammary gland development at the lactation stage through regulation of prolactin receptor expression and the downstream Jak2-Stat5 signaling pathway.
Increasing experimental data support that ZFHX3 gene plays a critical role in the pathogenesis of atrial fibrillation where it was found up-regulated. [review]
We showed that the ZFHX3 polymorphism, rs2106261 (A allele), was a risk marker for atrial fibrillation (A)F and AF-related phenotypes.
Nuclear localization of AT-motif binding factor 1 (ATBF1) indicates better prognosis of urothelial carcinoma.
Cellular localization of ATBF1 is correlated with its function in breast cancer. Nuclear ATBF1 was co-localized with chromosome during mitosis normally. Estrogen induced translocation of cytoplasmic ATBF1 to nuclei in MCF7.
The results suggest an additive effect of ZFHX3 and PTEN deletions on the development and progression of prostate neoplasia
Both ZFHX3 and PITX2c regulate expression of NPPA, TBX5 and NKX2.5.
In a Caucasian population, genetic variant rs7193343 SNP in ZFHX3 gene is associated with risk of atrial fibrillation.
Study found increased levels of ATBF1 in the cytoplasm of hippocampal pyramidal neurons in Alzheimer's disease brains and that ATBF1 binds to the C-terminal of A-beta-PP, increasing the steady state levels of A-beta-PP and resulting in increased A-beta production
The CAA repeat polymorphism in exon 9 of the ZFHX3 gene contributes to the Coronary heart disease susceptibility in the Chinese population.
ZFHX3 defects are associated with poor outcome in endometroid endometrial cancer.
Two SNPs (rs2106261, rs6499600) located in gene ZFHX3 showed significant associations with atrial fibrillation in a Chinese Han population.
ZFHX3 transcription is regulated in a transcript-specific fashion by independent cis-acting transcribed polymorphisms.
A missense mutation in ZFHX3 results in damage to the ZFHX3 protein structure in patients with extreme atrial fibrillation.
nuclear localization and SUMOylation are important for the transcription factor function of ATBF1, and that ATBF1 could cooperate with PML NBs to regulate protein SUMOylation in different biological processes.
Nuclear localization of ATBF1 is frequently interrupted in HNSCC, and the interruption is significantly associated with the progression of HNSCC
based on observations, nuclear ATBF1 staining was associated with low malignancy profiles of skin cancer
findings demonstrate that ZFHX3 maintains an active role in setting the pace of the circadian clock in adult mice, thus sustaining a key role in the maintenance of stable circadian rhythms independent of any earlier developmental disruptions
ZFHX3 knock-down in atrial myocytes dysregulated calcium homeostasis and increased atrial arrhythmogenesis.
Data show that knock-out of zinc finger homeobox 3 (ZFHX3) interrupted lactogenesis, resulting in underdeveloped glands.
Circadian transcription, driven by AT motifs in target gene promoters, is evident in adult suprachiasmatic nuclei and represents a circadian gene-regulatory axis, extending beyond the well-characterized transcriptional-translational feedback loop.
These findings provide in vivo evidence that ATBF1 is a tumor suppressor in the prostate
These data indicate that tachypacing decreased ATBF1, leading to enhanced STAT3 DNA-binding activity due to the reduced formation of a binary complex of ATBF1 and PIAS3.
findings indicate that Atbf1 plays a role in the development of pubertal mammary gland likely by modulating the function of estrogen-ER signaling in luminal cells and by modulating gene expression in basal cells
Atbf1 heterozygous mice displayed reduced body weight, preweaning mortality, increased cell proliferation, and attenuated cytokeratin 18 expression, indicating haploinsufficiency of Atbf1.
these results demonstrate that these phosphorylation sites on ATBF1 function as a defensive shield to calpain-1.
A novel signaling pathway that links ATM via CREB to the transcription factor ZFHX3, which in turn promotes survival of neurons by inducing expression of platelet-derived growth factor receptor beta, is reported.
Atbf1, serves as a novel pituitary regulator for one of the two required enhancers as shown by genetic and in vitro analysis
This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene.
zinc finger homeobox 3
, zinc finger homeobox protein 3-like
, AT-binding transcription factor 1
, AT-binding transcription factor1
, AT motif-binding factor 1
, alpha-fetoprotein enhancer binding protein
, alpha-fetoprotein enhancer-binding protein
, zinc finger homeobox protein 3
, zinc finger homeodomain protein 3
, AT motif binding factor 1
, AT motif-binding factor