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The ZFHX3 SNP rs2106261 minor allele is associated with lower atrial fibrillation (AF) recurrence rate after pulmonary vein isolation. Low baseline inflammation conferred by this allele may reduce AF recurrence risk.
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alterations in the expression and subcellular localization of ATBF1, as a result of posttranscriptional modifications, are associated with malignant features of colon tumours.
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Study identified DNA methylation (DNAm) site cg07786668 in ZFHX3 that is independently and significantly associated with myocardial infarction (MI) along with DNAm cg17218495 in SMARCA4. These results suggest that the development of MI might be influenced by changes in DNAm at these sites via a pathway that differs from that affected by cardiovascular disease-associated SNPs in these genes.
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using in vitro prolactin induced lactogenic differentiation in an HC11 mouse cell model and an in vivo conditional knockout mouse model we showed that mouse Zfhx3 is essential for mouse mammary epithelial cell differentiation and mouse mammary gland development at the lactation stage through regulation of prolactin receptor expression and the downstream Jak2-Stat5 signaling pathway.
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Increasing experimental data support that ZFHX3 gene plays a critical role in the pathogenesis of atrial fibrillation where it was found up-regulated. [review]
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We showed that the ZFHX3 polymorphism, rs2106261 (A allele), was a risk marker for atrial fibrillation (A)F and AF-related phenotypes.
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Nuclear localization of AT-motif binding factor 1 (ATBF1) indicates better prognosis of urothelial carcinoma.
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Cellular localization of ATBF1 is correlated with its function in breast cancer. Nuclear ATBF1 was co-localized with chromosome during mitosis normally. Estrogen induced translocation of cytoplasmic ATBF1 to nuclei in MCF7.
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The results suggest an additive effect of ZFHX3 and PTEN deletions on the development and progression of prostate neoplasia
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Both ZFHX3 and PITX2c regulate expression of NPPA, TBX5 and NKX2.5.
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In a Caucasian population, genetic variant rs7193343 SNP in ZFHX3 gene is associated with risk of atrial fibrillation.
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Study found increased levels of ATBF1 in the cytoplasm of hippocampal pyramidal neurons in Alzheimer's disease brains and that ATBF1 binds to the C-terminal of A-beta-PP, increasing the steady state levels of A-beta-PP and resulting in increased A-beta production
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The CAA repeat polymorphism in exon 9 of the ZFHX3 gene contributes to the Coronary heart disease susceptibility in the Chinese population.
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ZFHX3 defects are associated with poor outcome in endometroid endometrial cancer.
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Two SNPs (rs2106261, rs6499600) located in gene ZFHX3 showed significant associations with atrial fibrillation in a Chinese Han population.
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ZFHX3 transcription is regulated in a transcript-specific fashion by independent cis-acting transcribed polymorphisms.
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A missense mutation in ZFHX3 results in damage to the ZFHX3 protein structure in patients with extreme atrial fibrillation.
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nuclear localization and SUMOylation are important for the transcription factor function of ATBF1, and that ATBF1 could cooperate with PML NBs to regulate protein SUMOylation in different biological processes.
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Nuclear localization of ATBF1 is frequently interrupted in HNSCC, and the interruption is significantly associated with the progression of HNSCC
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based on observations, nuclear ATBF1 staining was associated with low malignancy profiles of skin cancer