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strong experimental evidence for a causal relationship between Tshz3 heterozygosity, functional defaults in cortical projection neurons, and autism spectrum disorder
suggest a novel mechanism for transcriptional repression by TSHZ3 in which TSHZ3 and BAF57 (show SMARCE1 Proteins) cooperate to modulate MyoD (show MYOD1 Proteins) activity on the Myog (show MYOG Proteins) promoter to regulate skeletal muscle differentiation.
Thus, a single gene, Tshz3, controls the development of diverse components of the circuitry required for breathing.
Mice that are null mutant for the Teashirt3 (Tshz3) gene exhibit congenital pelvi-ureteric junction obstruction with defective smooth muscle differentiation and absent peristalsis in the proximal ureter.
three mouse Tsh genes are functionally equivalent to the Drosophila tsh gene when expressed in developing Drosophila embryos
ureteric smooth muscle cell precursors express the transcription factor teashirt 3 (TSHZ3), and Tshz3-null mutants have congenital hydronephrosis without anatomical obstruction
Gene product expressions of SHH (show SHH Proteins), TBX18 (show TBX18 Proteins) and TSHZ3 are statistically higher in patients with UPJ obstruction, when compared with control group. The explanation may be the reactivation of the processes, which had shown their effects in the embryological period, due to the chronic inflammation and long-term micro-trauma created by the disease
Gli3 (show GLI3 Proteins) and Teashirt3 might play an important role in the normal development of the ureter.
The dynamic expression of Sox9 and the interaction between TSHZ3, SOX9 and MYOCD provide a mechanism that regulates the pace the myogenic program in the ureter.
TSHZ3 gene promoter was found to be methylated in all the breast/prostate cancer cell lines and some of the breast cancer clinical specimens while the TSHZ2 gene promoter was unmethylated except for the MDA-MB-231 breast cancer cell line.
Mutations in TSHZ2 and TSHZ3 are not a major cause of pelvi-ureteric junction obstruction, at least in Albanian and Macedonian populations.
Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up- regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity).
teashirt family zinc finger 3
, zinc finger protein 537
, teashirt 3
, teashirt homolog 3
, teashirt zinc finger family member 3