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MIF was found to be essential for axis formation and neural development of Xenopus embryos.
Data show that the mif pathway is required for both sensory hair cell (HC) and sensory neuronal cell survival in the ear, for HC differentiation, semicircular canal formation, statoacoustic ganglion (SAG (show SAG Proteins)) development, and lateral line HC differentiation.
MIF knockdown significantly accentuates hearing loss in young mice.
Mif mediates PAR4 (show F2RL3 Proteins)-induced bladder pain through urothelial HMGB1 (show HMGB1 Proteins).
These results show although high systemic levels of MIF contribute to the development of type 2 diabetes mellitus pathology.
High MIF expression is associated with progressive multiple sclerosis.
The lack of MIF leads to disturbances of systemic and hippocampal insulin (show INS Proteins) sensitivity, which are possibly responsible for memory deficits and anxiety, most likely through decreased PSA (show NPEPPS Proteins)-NCAM (show NCAM1 Proteins)-mediated neuroplasticity rather than through neurotrophic factors.
These data indicate the functional role of the MIF-COX (show CPOX Proteins)-p53 (show TP53 Proteins) axis in inflammation and cancer at the genomic and proteomic levels in COX-2-ablated cells.
Our results showed that MIF regulates MCP-1 (show CPT1B Proteins) expression in hepatocytes of injured liver via CD74 (show CD74 Proteins), CD44 (show CD44 Proteins), and p38 MAPK (show MAPK14 Proteins) in an autocrine manner.
MIF is involved in the pathogenesis of AF, probably by down-regulating the protein and gene expression of Cx43 via ERK1/2 kinase activation
Endogenous MIF reduces the accumulation and toxicity of misfolded SOD1 (show SOD1 Proteins) in a mouse model of amyotrophic lateral sclerosis.
Gene expression of MIF was 30-fold higher in the heart, compared to skeletal muscle and protein expression of MIF was 3-fold higher in the heart compared to skeletal muscle.
The expression collagen type 3, alpha1 (Col3A1 (show COL3A1 Proteins)), matrix metalloproteinase (MMP)2 (show MMP2 Proteins)/-9 and transforming growth factor (TGF)beta (show TGFB1 Proteins) was higher in patients with permanent atrial fibrillation (AF), compared with patients in sinus rhythm (SR), and the expression levels of MIF (show AMH Proteins) were also increased in AF. MIF (show AMH Proteins) was involved in the structural remodeling that accompanies AF, possibly by promoting the proliferation of cardiac fibroblasts.
the findings of the present study demonstrated that MIF (show AMH Proteins) is a key component in lung cancer progression through promoting the Warburg effect, and that the novel MIF (show AMH Proteins)/NFkappaB (show NFKB1 Proteins)/HIF1alpha (show HIF1A Proteins) axis may prove to be useful for the development of new strategies for treating patients with lung cancer
These results potentially support an effect of MIF, but not Type I IFN, in heightened systemic lupus erythematosus disease severity in Asian systemic lupus erythematosus. The associations of MIF and Asian ethnicity with PAD are at least partly independent
High MIF (show AMH Proteins) expression is associated with progressive multiple sclerosis.
Increased perioperative MIF (show AMH Proteins)-levels are related to an increased risk of adverse outcome in complex aortic surgery and may represent a biomarker for risk stratification in complex aortic surgery.
No association showed between SLE and the MIF (show AMH Proteins) -173 C allele, the -794CATT7 allele, and the -794CATT7-MIF (show AMH Proteins)-173C haplotype with high heterogeneity.
Studied correlation of serum macrophage migration inhibitory factor (MIF) and atrial fibrillation (AF) patients and healthy subjects; found higher serum MIF (show AMH Proteins) concentrations in AF patients than in healthy subjects.
genetic polymorphisms of MIF (show AMH Proteins) may increase the risk of posttransplant development of donor specific antibodies in kidney allograft recipients
We reviewed the association of the MIF (show AMH Proteins) rs755622*C allele with systemic sclerosis, and described a phenotype-specific association of this variant with the susceptibility to develop pulmonary arterial hypertension in patients with diffuse cutaneous systemic sclerosis.
Authors report that cysteine 81 within MIF (show AMH Proteins) serves as a "switch cysteine" for the conversion of redMIF to oxMIF. Modulating cysteine 81 by thiol reactive agents leads to significant structural rearrangements of the protein, resulting in a decreased beta-sheet content and an increased random coil content, but maintaining the trimeric quaternary structure.
In conclusion, the bovine ampulla and isthmus have higher MIF expression during the postovulatory phase.
plasma MIF concentrations may increase with age in months and parity, but do not change either before and after parturition or before and after postpartum first ovulation in Japanese black cows
Data suggest that, in obese cows, expression of MIF is suppressed in the ampulla and isthmus of Fallopian tubes as compared to normal-weight cows; however, MIF expression is also lower in Fallopian tubes of lean cows. The primary site of MIF expression in Fallopian tube ampulla/isthmus is the tunica mucosa. These studies were conducted in Japanese Black calves.
The objective of the present study was to determine if SNPs in 5' region of bovine MIF affects its promoter activity.
MIF plays a role in early embryo development, and further characterization of MIF expression and its regulation in the endometrium will add significantly to our understanding of early embryo-uterine interactions
The diverse actions of MIF within the immuno-neuroendocrine system may be a result of its occurrence in different isoforms and oligomerization states.
The purification of macrophage migration inhibitory factor (MIF) from bovine brain cytosol and its partial characterization are reported.
Transcription of MIF is induced by activation of PPARgamma2 (show PPARG Proteins) and inhibited by excessive resistin (show RETN Proteins).
The high activity of MIF in the maternal and fetal tissues throughout placentation and its expression in the nonpregnant uterus indicate a regulatory role for MIF during embryo receptivity and epitheliochorial placentation
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways.
, L-dopachrome tautomerase
, Phenylpyruvate tautomerase
, macrophage migration inhibitory factor
, phenylpyruvate tautomerase
, Macrophage migration inhibitory factor
, delayed early response protein 6
, glycosylation-inhibiting factor
, glutathione-binding 13 kDa protein