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MIF was found to be essential for axis formation and neural development of Xenopus embryos.
Data show that the mif pathway is required for both sensory hair cell (HC) and sensory neuronal cell survival in the ear, for HC differentiation, semicircular canal formation, statoacoustic ganglion (SAG (show SAG Proteins)) development, and lateral line HC differentiation.
Our results showed that MIF regulates MCP-1 (show CPT1B Proteins) expression in hepatocytes of injured liver via CD74 (show CD74 Proteins), CD44 (show CD44 Proteins), and p38 MAPK (show MAPK14 Proteins) in an autocrine manner.
MIF is involved in the pathogenesis of AF, probably by down-regulating the protein and gene expression of Cx43 via ERK1/2 kinase activation
Endogenous MIF reduces the accumulation and toxicity of misfolded SOD1 (show SOD1 Proteins) in a mouse model of amyotrophic lateral sclerosis.
Gene expression of MIF was 30-fold higher in the heart, compared to skeletal muscle and protein expression of MIF was 3-fold higher in the heart compared to skeletal muscle.
renal tubular MIF is an endogenous renoprotective factor in progressive kidney diseases
locally produced MIF in the inflammatory bone lytic site is engaged in the chemoattraction of circulating CXCR4 (show CXCR4 Proteins)+ osteoclast precursor cells.
MIF expression was induced in chondrocytes of tissue-engineered cartilage, and could exert a profound effect on chondrocytes by promoting cartilage maturation. MIF could also regulate the phenotype of surrounding macrophages, impairing the maturation of transplanted tissues.
loss of autophagy, by pharmacological inhibition or siRNA silencing of Atg5 (show ATG5 Proteins), enhances MIF secretion by monocytes and macrophages.
CHD7 is an important factor in the proliferation and stemness maintenance of neural stem/progenitor cells.
MIF-deficient mice have reduced Nippostrongylus brasiliensis burden and mounted an enhanced type 2 immune response, including increased Gata3 (show GATA3 Proteins) expression and interleukin-13 (show IL13 Proteins) production in the mesenteric lymph nodes
In conclusion, MIF (show AMH Proteins) rs755622 polymorphism increases breast cancer susceptibility in Chinese population, especially among elder patients.
MIF (show AMH Proteins) coreceptor CD44 (show CD44 Proteins) is expressed by rheumatoid synovial fibroblasts in a MIF (show AMH Proteins) allele-dependent fashion and undergoes functional regulation and activation by autocrine/paracrine MIF (show AMH Proteins)
High MIF (show AMH Proteins) expression is associated with hepatocellular injury and graft rejection.
Increased serum MIF (show AMH Proteins) levels are associated with the elevation of pre-diabetic risk.
The assay monitors the increase in absorbance at 320 nm resulting from keto-to-enol tautomerization of 4-hydroxyphenylpyruvate, a reaction catalyzed by MIF (show AMH Proteins). We ran a full-diversity screen evaluating the inhibitory activity of 1.6 million compounds.
The rs5844572 polymorphism in MIF (show AMH Proteins) is linked to the rate of progression and extent of fibrosis in Biliary Atresia Patients, but not with disease susceptibility.
Absolute numbers of MIF (show AMH Proteins) and IL-1beta (show IL1B Proteins) mRNA molecules are both accurate and reliable predictors of antidepressant response.
The knockdown of D-DT and MIF (show AMH Proteins), individually and additively, inhibited the proliferation, migration, and invasion in HeLa and SiHa cells and restrained the growth of xenograft tumor.
No association between coronary artery disease class and -794 CATT5-8 MIF polymorphisms with soluble MIF levels in CAD subjects.
plasma MIF concentrations may increase with age in months and parity, but do not change either before and after parturition or before and after postpartum first ovulation in Japanese black cows
Data suggest that, in obese cows, expression of MIF is suppressed in the ampulla and isthmus of Fallopian tubes as compared to normal-weight cows; however, MIF expression is also lower in Fallopian tubes of lean cows. The primary site of MIF expression in Fallopian tube ampulla/isthmus is the tunica mucosa. These studies were conducted in Japanese Black calves.
The objective of the present study was to determine if SNPs in 5' region of bovine MIF affects its promoter activity.
MIF plays a role in early embryo development, and further characterization of MIF expression and its regulation in the endometrium will add significantly to our understanding of early embryo-uterine interactions
The diverse actions of MIF within the immuno-neuroendocrine system may be a result of its occurrence in different isoforms and oligomerization states.
The purification of macrophage migration inhibitory factor (MIF) from bovine brain cytosol and its partial characterization are reported.
Transcription of MIF is induced by activation of PPARgamma2 (show PPARG Proteins) and inhibited by excessive resistin (show RETN Proteins).
The high activity of MIF in the maternal and fetal tissues throughout placentation and its expression in the nonpregnant uterus indicate a regulatory role for MIF during embryo receptivity and epitheliochorial placentation
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways.
, L-dopachrome tautomerase
, Phenylpyruvate tautomerase
, macrophage migration inhibitory factor
, phenylpyruvate tautomerase
, Macrophage migration inhibitory factor
, delayed early response protein 6
, glycosylation-inhibiting factor
, glutathione-binding 13 kDa protein