anti-Mouse (Murine) Sepiapterin Reductase antibody for Enzyme Immunoassay

Recommended Sepiapterin Reductase Antibody (supplied by: Log in to see )

Antigen
Sepiapterin Reductase (SPR) Antibodies
  • SDR38C1
  • AA409688
  • ENSMUSG00000071345
  • Gm10328
  • CG12117
  • Dmel\\CG12117
  • SR
  • sptr
  • xspr
  • DDBDRAFT_0188686
  • DDBDRAFT_0191275
  • DDB_0188686
  • DDB_0191275
  • sepiapterin reductase
  • Sepiapterin reductase
  • sepiapterin reductase L homeolog
  • SPR
  • Spr
  • Sptr
  • spr.L
  • sprE
  • CpipJ_CPIJ000511
  • sr
  • spr
Epitope
C-Term, AA 232-261
15
10
10
7
3
3
2
2
2
2
1
1
1
Reactivity
Human, Mouse (Murine)
121
50
35
16
2
2
2
Host
Rabbit
82
42
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
107
40
30
30
26
14
13
12
9
6
5
1
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Catalog No. ABIN954723
$ 390.50
Plus shipping costs $45.00

General

Antigen Sepiapterin Reductase (SPR) Antibodies
Epitope C-Term, AA 232-261
(15), (10), (10), (7), (3), (3), (2), (2), (2), (2), (1), (1), (1)
Reactivity Human, Mouse (Murine)
(121), (50), (35), (16), (2), (2), (2)
Host Rabbit
(82), (42)
Clonality
Polyclonal
Conjugate Un-conjugated
(4), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Western Blotting (WB)
(107), (40), (30), (30), (26), (14), (13), (12), (9), (6), (5), (1)
Pubmed 3 references available
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Product details

Target Details Application Details Handling References Images
Specificity This antibody recognizes Sepiapterin reductase / SPRat N-term.
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse
Purification Purified through a Protein A column followed by peptide affinity purification
Immunogen Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 232-261aa) of human Sepiapterin reductase / SPR.
Isotype Ig Fraction

Target Details

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Antigen
Alternative Name Sepiapterin Reductase / SPR (SPR Antibody Abstract)
Background The SPR gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiapterin reductase deficiency. A pseudogene has been identified on chromosome 1.Synonyms: EC 1.1.1.153, SDR38C1, short chain dehydrogenase/reductase family 38C member 1
Gene ID 6697
NCBI Accession NP_003115
Pathways Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration

Application Details

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Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

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Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References

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Background publications

Leu-Semenescu, Arnulf, Decaix, Moussa, Clot, Boniol, Touitou, Levy, Vidailhet, Roze: "Sleep and rhythm consequences of a genetically induced loss of serotonin." in: Sleep, Vol. 33, Issue 3, pp. 307-14, 2010

Schnetz-Boutaud, Anderson, Brown, Wright, Abramson, Cuccaro, Gilbert, Pericak-Vance, Haines: "Examination of tetrahydrobiopterin pathway genes in autism." in: Genes, brain, and behavior, Vol. 8, Issue 8, pp. 753-7, 2009

Clot, Grabli, Cazeneuve, Roze, Castelnau, Chabrol, Landrieu, Nguyen, Ponsot, Abada, Doummar, Damier, Gil, Thobois, Ward, Hutchinson, Toutain, Picard, Camuzat, Fedirko, Sân, Bouteiller, LeGuern, Durr, Vidailhet, Brice: "Exhaustive analysis of BH4 and dopamine biosynthesis genes in patients with Dopa-responsive dystonia." in: Brain : a journal of neurology, Vol. 132, Issue Pt 7, pp. 1753-63, 2009

Images

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Supplier Images
Western Blotting (WB) image for anti-Sepiapterin Reductase (SPR) (AA 232-261), (C-Term) antibody (ABIN954723) Western blot analysis of Sepiapterin reductase (arrow) in mouse liver tissue lysates ...