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Human DICER1 Protein expressed in HEK-293 Cells - ABIN2719477
Zhang, Li, Deng, Liu, Chen, Tang, Wang, Cao, Fang, Wen, Xu, Chen, Shi, Li, Xie, Tang: Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents. in Nucleic acids research 2016
Dicer localisation is dynamic and not exclusively cytoplasmic, particularly in cells exposed to DNA damage.
Loss of Dicer1 expression is associated with ovarian tumor cells originating in the fallopian tube stroma.
Dicer is crucial for maintenance of adult dopaminergic neurons, whereas a stimulation of microrna production can promote neuronal survival.
Data show that Dicer1(Flox/-) mice histologically and genetically resemble human angiosarcoma.
These findings reveal that Dicer, through its production of mature miRNAs, plays a key role in the maintenance of monosynaptic sensory-motor circuits.
we found that the miRNA biogenesis enzyme DICER was required for the binding of the PRC2 core components EZH2 and SUZ12, and for the presence of the PRC2-mediated histone modification H3K27me3 at many bivalent genes
Lack of Dicer leads to oxidative stress, cytosolic acidification, upregulated NHE1 (show SLC9A1 Proteins) expression and activity as well as swelling of CD4 (show CD4 Proteins)+ T cells, functions all reversed by miR (show MLXIP Proteins)-15b or miR (show MLXIP Proteins)-200b.
Results show that elevated miR (show MLXIP Proteins)-15b as an early response to Dicer depletion silenced Pim-1 (show PIM1 Proteins) kinase resulting in mitochondrial dysfunction. Rescue experiments demonstrated that suppression of miRNA-15b induction in Dicer-deleted adult hearts result in marked amelioration of cardiac dysfunction.
Dicer1 ablation impairs Shh-induced granule neuron precursor proliferation by disrupting the expression of distinct cell cycle regulator genes that are targets of miR-17 approximately 92 cluster members. This study establishes a molecular link between miRNAs and cell cycle progression in the proliferating Granule neuron precursors during normal cerebellar development and may facilitate miRNA application in treating med...
Dicer maintains the identity and function of proprioceptive sensory neurons. Results suggest that Dicer and, most likely by extension, microRNAs are crucially important for maintaining proprioception. Additionally, this study hints at the larger question of how neurons maintain their functional and molecular specificity.
neither likely pathogenic nor pathogenic variants in DICER1 appear to play a major role in transposition of the great arteries.
first report of DICER1 mutations in pulmonary blastoma.
Decreased argonaute 2 (show EIF2C2 Proteins) and dicer1 in peripheral blood mononuclear cells from War Veterans with post-traumatic stress disorder leads to diminished miRNA resulting in elevated inflammation.
The activation of Dicer suppressed the production of TNFalpha (show TNF Proteins). These results suggested that Dicer can balance the production of TNFalpha (show TNF Proteins), and thus may serve as a regulator of the immune response in patients with RA.
Dicer efficiently suppresses the replication of adenovirus via cleavage of adenovirus-encoding small RNAs.
The present study demonstrates that hypoxia-induced downregulation of Dicer serves as key mechanism in the maintenance of the hypoxic response in HCC (show FAM126A Proteins) and that prevention of hypoxic suppression of Dicer not only alleviates hypoxia-induced upregulation of HIF1a (show HIF1A Proteins) and HIF2a (show EPAS1 Proteins) and other key hypoxia-responsive/HIF target genes, but also inhibits hypoxia-induced metastatic phenotypes such as EMT (show ITK Proteins) and increased cell motility.
two cases with DICER1 mutations were found to have lung cysts preceding the diagnosis of pathogenesis of pleuropulmonary blastoma
Decreased Dicer expression was found in chronic lymphocytic leukemia patients with chromosomal deletions.
Most neoplasms in the syndrome have been shown to harbor biallelic pathogenic variants in DICER1, usually a germline loss-of-function pathogenic variant in one allele that can occur in any domain and a tumor-specific pathogenic somatic variant in exons encoding the RNase IIIb domain of the second allele
Describe familial HCC (show FAM126A Proteins) associated with a novel DICER1 germline mutation and altered liver zonation. Familial and sporadic HCCs (show HCCS Proteins) carrying DICER1 mutations are associated with CTNNB1 (show CTNNB1 Proteins) mutation and characterized by a reduced expression of specific mature miRNAs.
Diminished androgen action during gestation induces changes in Dicer1 mRNA expression.
The primary cDNA sequence of porcine Dicer was determined, and its expression in porcine oocytes and early stage embryos was confirmed.
Studied Dicer gene expression during early bovine embryo development.An increase in Dicer expression was detected in the mature oocytes sampled (P<0.05), implying that gene repression occurs during meiosis II.
Dynamic miRNA expression patterns during retinal regeneration in zebrafish: reduced dicer or miRNA expression suppresses proliferation of Muller glia-derived neuronal progenitor cells
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants.
Dicer1, Dcr-1 homolog
, endoribonuclease Dicer
, dicer 1, ribonuclease type III
, double-stranded RNA-specific endoribonuclease type III
, double-strand-specific ribonuclease mDCR-1
, dicer 1, double-stranded RNA-specific endoribonuclease
, helicase MOI
, helicase with RNAse motif
, dsRNA-specific ribonuclease