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Human DICER1 Protein expressed in HEK-293 Cells - ABIN2719477
Zhang, Li, Deng, Liu, Chen, Tang, Wang, Cao, Fang, Wen, Xu, Chen, Shi, Li, Xie, Tang: Dicer interacts with SIRT7 and regulates H3K18 deacetylation in response to DNA damaging agents. in Nucleic acids research 2016
Loss of Dicer1 expression is associated with ovarian tumor cells originating in the fallopian tube stroma.
Dicer is crucial for maintenance of adult dopaminergic neurons, whereas a stimulation of microrna production can promote neuronal survival.
Data show that Dicer1(Flox/-) mice histologically and genetically resemble human angiosarcoma.
These findings reveal that Dicer, through its production of mature miRNAs, plays a key role in the maintenance of monosynaptic sensory-motor circuits.
we found that the miRNA biogenesis enzyme DICER was required for the binding of the PRC2 core components EZH2 and SUZ12, and for the presence of the PRC2-mediated histone modification H3K27me3 at many bivalent genes
Lack of Dicer leads to oxidative stress, cytosolic acidification, upregulated NHE1 (show SLC9A1 Proteins) expression and activity as well as swelling of CD4 (show CD4 Proteins)+ T cells, functions all reversed by miR (show MLXIP Proteins)-15b or miR (show MLXIP Proteins)-200b.
Results show that elevated miR (show MLXIP Proteins)-15b as an early response to Dicer depletion silenced Pim-1 (show PIM1 Proteins) kinase resulting in mitochondrial dysfunction. Rescue experiments demonstrated that suppression of miRNA-15b induction in Dicer-deleted adult hearts result in marked amelioration of cardiac dysfunction.
Dicer1 ablation impairs Shh-induced granule neuron precursor proliferation by disrupting the expression of distinct cell cycle regulator genes that are targets of miR-17 approximately 92 cluster members. This study establishes a molecular link between miRNAs and cell cycle progression in the proliferating Granule neuron precursors during normal cerebellar development and may facilitate miRNA application in treating med...
Dicer maintains the identity and function of proprioceptive sensory neurons. Results suggest that Dicer and, most likely by extension, microRNAs are crucially important for maintaining proprioception. Additionally, this study hints at the larger question of how neurons maintain their functional and molecular specificity.
this study shows that Dicer deficiency differentially impacts microglia of the developing and adult brain
Describe familial HCC (show FAM126A Proteins) associated with a novel DICER1 germline mutation and altered liver zonation. Familial and sporadic HCCs (show HCCS Proteins) carrying DICER1 mutations are associated with CTNNB1 (show CTNNB1 Proteins) mutation and characterized by a reduced expression of specific mature miRNAs.
Findings imply that Dicer inhibits clear cell renal cell carcinoma (show MOK Proteins) (ccRCC) metastasis and may serve as promising prognostic biomarkers for ccRCC patients.
Our results suggest that, in contrast to FOXL2 (show FOXL2 Proteins) mutations in adult granulosa cell tumours (A-GCTs), DICER1 mutations in Sertoli-Leydig cell tumours (SLCTs) might be more useful for prognosis than for diagnosis.
Low Dicer status was associated with poor prognosis in ovarian cancer, otorhinolaryngological tumors and ematological malignancies.
Study identified nonsense germ-line and missense somatic mutations in DICER1 causing a truncated protein at the IIIb domain level that segregate within a family affected with Dicer1 syndrome.
Data suggest that DICER plays a pleiotropic role in glioma stem-like cells, modulating the growth properties of glioma tumors arising from these cells and their response to DNA damage-inducing agents, leading to formation of larger tumors that are more sensitive to radiation.
validate the results of the aforementioned animal study and demonstrate downregulation of DICER1 gene and abnormal miRNA profile in myelodysplastic syndrome
We found that inhibition of DICER processing of miR (show MLXIP Proteins)-544 through the use of a small molecule abolished miR (show MLXIP Proteins)-544 function in regulating adaptation of breast cancer cells to hypoxic stress.
Data show that the expression of miRNAs and Dicer1 were downregulated in cells lines expressing HTLV-I HBZ (show HBZ Proteins) protein (HBZ (show HBZ Proteins)) as well as in fresh CD4 (show CD4 Proteins) (+) cells from acute adult T cell Leukemia (ATL) patients.
the DICER rs1057035 TT genotype and DROSHA (show DROSHA Proteins) rs644236 CC genotype were associated with the development of GD and the differentiation between GD and HD, respectively. The expression levels of DICER and DROSHA (show DROSHA Proteins) genes were low in AITD and differed depending on the intractability of GD and the severity of HD, respectively.
Diminished androgen action during gestation induces changes in Dicer1 mRNA expression.
The primary cDNA sequence of porcine Dicer was determined, and its expression in porcine oocytes and early stage embryos was confirmed.
Studied Dicer gene expression during early bovine embryo development.An increase in Dicer expression was detected in the mature oocytes sampled (P<0.05), implying that gene repression occurs during meiosis II.
Dynamic miRNA expression patterns during retinal regeneration in zebrafish: reduced dicer or miRNA expression suppresses proliferation of Muller glia-derived neuronal progenitor cells
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants.
Dicer1, Dcr-1 homolog
, endoribonuclease Dicer
, dicer 1, ribonuclease type III
, double-stranded RNA-specific endoribonuclease type III
, double-strand-specific ribonuclease mDCR-1
, dicer 1, double-stranded RNA-specific endoribonuclease
, helicase MOI
, helicase with RNAse motif
, dsRNA-specific ribonuclease