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anti-Human DROSHA Antibodies:
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Human Polyclonal DROSHA Primary Antibody for ICC, IF - ABIN315874
Hsieh, Lin, Liu, Chang, Shih, Zhong, Lee, Tan: WDHD1 modulates the post-transcriptional step of the centromeric silencing pathway. in Nucleic acids research 2011
Show all 5 Pubmed References
Human Polyclonal DROSHA Primary Antibody for ELISA, WB - ABIN188686
Thomson, Newman, Parker, Morin-Kensicki, Wright, Hammond: Extensive post-transcriptional regulation of microRNAs and its implications for cancer. in Genes & development 2006
Increased Drosha expression was found in chronic lymphocytic leukemia patients without chromosomal deletions.
point mutations in the RNaseIIIb domain of Drosha implicated in Wilms tumors differentially affected cleavage of the 5' and 3' strands of pri-miRNAs in vitro.
the DICER (show DICER1 Antibodies) rs1057035 TT genotype and DROSHA rs644236 CC genotype were associated with the development of GD and the differentiation between GD and HD, respectively. The expression levels of DICER (show DICER1 Antibodies) and DROSHA genes were low in AITD and differed depending on the intractability of GD and the severity of HD, respectively.
Overexpression of LAMC2 (show LAMC2 Antibodies) and knockdown of CD82 (show CD82 Antibodies) markedly promoted GC cell invasion and activated EGFR (show EGFR Antibodies)/ERK1/2-MMP7 (show MMP7 Antibodies) signaling via upregulation of the expression of phosphorylated (p)-EGFR (show EGFR Antibodies), p-ERK1/2 and MMP7 (show MMP7 Antibodies).
A significant association was observed between 2 candidate genes and AD, TARBP2 (show TARBP2 Antibodies) rs784567 genotype and AD (chi=6.292, P=0.043), and a trend for RNASEN rs10719 genotype (chi=4.528, P=0.104) and allele (P=0.035). On controlling for Age, we found that for the TARBP2 (show TARBP2 Antibodies)-RNASEN association with AD the age variation was a risk factor for AD risk (P<0.001; OR=1.104; 95% CI, 1.059-1.151)
BRG1 (show SMARCA4 Antibodies) and SMARCAL1 (show SMARCAL1 Antibodies), members of the ATP-dependent chromatin remodelling family, are shown to co-regulate the transcription of DROSHA, DGCR8 (show DGCR8 Antibodies), and DICER (show DICER1 Antibodies) in response to double-strand DNA breaks
Mechanistic dissection reveals that NEAT1 broadly interacts with the NONO (show NONO Antibodies)-PSF (show IGFBP7 Antibodies) heterodimer as well as many other RNA-binding proteins and that multiple RNA segments in NEAT1, including a 'pseudo pri-miRNA' near its 3' end, help attract the Drosha-DGCR8 (show DGCR8 Antibodies) Microprocessor.
Results show that Mammalian DROSHA genes have evolved a conserved hairpin structure spanning a specific exon-intron junction serving as a substrate for the microprocessor in human but not in murine cells. This hairpin element decides whether the overlapping exon is alternatively or constitutively spliced. Also, DROSHA promotes skipping of the overlapping exon in human cells independently of its cleavage function.
Report DROSHAnumerous processing sites on primary microRNAs and noncanonical substrates which may serve as cis (show CISH Antibodies)-elements for DROSHA-mediated gene regulation.
HPV E6/E7 increased expression of DROSHA and DICER (show DICER1 Antibodies) mRNA and protein in cervical carcinoma cells.
Drosha knockout indicated a role for let-7 miRNAs in developmental hematopoiesis.
Identification of Microprocessor component DROSHA as a novel DNMT1 (show DNMT1 Antibodies)-interactor.
Results show that Mammalian DROSHA genes have evolved a conserved hairpin structure spanning a specific exon-intron junction serving as a substrate for the microprocessor in human but not in murine cells.
Knockdown of NFIB (show NFIB Antibodies) in Drosha-deficient hippocampal neural stem cells restores neurogenesis, suggesting that the Drosha/NFIB (show NFIB Antibodies) mechanism robustly prevents oligodendrocyte fate acquisition in vivo.
FMRP (show FMR1 Antibodies) is involved in pri-miRNA processing via enhancing DROSHA expression that may play an important role in fragile X (show FMR1 Antibodies) syndrome.
our findings suggest that DROSHA is involved in stromal decidualization and may play an important role in embryo implantation in mice.
These data indicate that oocyte DICER (show DICER1 Antibodies) expression in the fetal ovary is required, and oocyte DROSHA is dispensable, for postnatal follicular development and female fertility in adulthood.
Drosha repressed the expression of two mRNAs encoding inhibitors of myelopoiesis in early hematopoietic progenitors.
Early postnatal ablation of the microRNA-processing enzyme, Drosha, causes chondrocyte death and impairs the structural integrity of the articular cartilage.
Data indicate that Arf-deficient cells transformed by oncogenic Ras were dependent on increased Drosha expression as Drosha knockdown was sufficient to inhibit Ras-dependent cellular transformation.
Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002
, ribonuclease 3
, Ribonuclease 3
, RNase III
, drosha, double-stranded RNA-specific endoribonuclease
, nuclear RNase III Drosha
, protein Drosha
, putative protein p241 which interacts with transcription factor Sp1
, putative ribonuclease III
, ribonuclease III, nuclear
, ribonuclease type III, nuclear
, ethanol induced 2