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RAN Antigen Profile

Antigen Summary

RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.

Alternative names and synonyms associated with RAN

  • RAN, member RAS oncogene family (RAN) ELISA Kit
  • RAN, member RAS oncogene family (Ran) ELISA Kit
  • RAN, member RAS oncogene family S homeolog (ran.S) ELISA Kit
  • RAN, member RAS oncogene family (ran) ELISA Kit
  • RAS-like, family 2, locus 9 (Rasl2-9) ELISA Kit
  • CG1404 gene product from transcript CG1404-RC (Ran) ELISA Kit
  • ARA24 ELISA Kit
  • Gsp1 ELISA Kit
  • TC4 ELISA Kit
  • ran ELISA Kit
  • ara24 ELISA Kit
  • gsp1 ELISA Kit
  • ran-1 ELISA Kit
  • tc4 ELISA Kit
  • M2 ELISA Kit
  • Ran ELISA Kit
  • Ran/M2 ELISA Kit
  • Rasl2-9-ps ELISA Kit
  • AAF30287 ELISA Kit
  • CG1404 ELISA Kit
  • Dmel\CG1404 ELISA Kit
  • dran ELISA Kit
  • l(1)G0075 ELISA Kit
  • ran10A ELISA Kit
  • fc16b04 ELISA Kit
  • wu:fc16b04 ELISA Kit

Protein level used designations for RAN

GTP-binding nuclear protein Ran , GTPase Ran , OK/SW-cl.81 , RanGTPase , androgen receptor-associated protein 24 , guanosine triphosphatase Ran , member RAS oncogene family , ras-like protein TC4 , ras-related nuclear protein , RAN, member RAS oncogene family , RAN, member RAS oncogene family pseudogene 1 , GTP-binding nuclear protein Ran, testis-specific isoform , RAS-like, family 2, locus 9, pseudogene , CG1404-PA , CG1404-PB , Ran GTPase , ran-PA , ran-PB

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397655 Sus scrofa
442976 Canis lupus familiaris
448091 Xenopus (Silurana) tropicalis
452414 Pan troglodytes
540457 Bos taurus
100173539 Pongo abelii
100302079 Ovis aries
100499482 Canis lupus familiaris
396193 Gallus gallus
19428 Mus musculus
44072 Drosophila melanogaster
30572 Danio rerio
709200 Macaca mulatta
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