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We then show that Rx controls proliferation within the MBNB clones independently of Tailless (Tll (show NR2E1 Proteins)) and Prospero (show PROX1 Proteins) (Pros), and does not regulate the expression of other key regulators of MB development, Eyeless (Ey) and Dachshund (Dac (show FBXW4 Proteins)). Our data support that the role of Rx in forebrain development is conserved between vertebrates and fly.
Drx is not required for establishment of the drosophila visual system.
PACT interacts with LGP2 and this interaction is enhanced by encephalomyocarditis virus (EMCV) infection. In vitro interaction analyses using purified recombinant proteins confirmed that the single-stranded Theiler's murine encephalitis virus genome enhanced the interaction between LGP2 and PACT.
Deletion of Rax in the eye generated loss of central visual pathways and the suprachiasmatic nucleus was absent.
the role of Rax in the early stages of hypothalamic development
Data (including data from studies in transgenic/knockout mice) suggest that PACT/RAX (protein activator of protein kinase (show CDK7 Proteins) R) functions as negative regulator of PKR/Eif2ak2 (show EIF2AK2 Proteins) (protein kinase (show CDK7 Proteins) R) in development of postnatal anterior pituitary tissue.
Deficiency of PKR (show EIF2AK2 Proteins) diminished peripheral inflammatory responses following E. coli
Rax and Crx (show CRX Proteins) cooperatively transactivate Rhodopsin (show RHO Proteins) and cone opsin (show RHO Proteins) promoters and an optimum Rax expression level to transactivate photoreceptor gene expression exists.
This study provided evidence that Rax is required for the normal differentiation and patterning of hypothalamic tanycytes and ependymal cells, as well as for maintenance of the cerebrospinal fluid-hypothalamus barrier.
miR (show MLXIP Proteins)-29b mediated ethanol neurotoxicity through the SP1 (show SP1 Proteins)/RAX/PKR (show EIF2AK2 Proteins) cascade.
The protein kinase (show CDK7 Proteins) PKR (show EIF2AK2 Proteins) is critical for LPS (show TLR4 Proteins)-induced iNOS (show NOS2 Proteins) production but is dispensable for inflammasome activation in macrophages.
our study illustrates that Rax is required in ARC (show NOL3 Proteins)/VMH progenitors to specify neuronal phenotypes within this hypothalamic brain region.
The three consanguineous Egyptian anophthalmia patients carry a novel homozygous c.543+3A>G mutation (IVS2+3A>G) in RAX.
Photosensitive photoreceptor cells can be generated by combinations of transcription factors. The combination of CRX and RX generate immature photoreceptors: and additional NEUROD promotes maturation.
Mutations in the newly identified RAX regulatory sequence are not a frequent cause of micro/anophthalmia.
This gene encodes a homeobox-containing transcription factor that functions in eye development. The gene is expressed early in the eye primordia, and is required for retinal cell fate determination and also regulates stem cell proliferation. Mutations in this gene have been reported in patients with defects in ocular development, including microphthalmia, anophthalmia, and coloboma.
, drosophila Rx
, retinal homeobox
, retinal homeobox protein Rx1
, retinal homeobox protein Rx2
, retina and anterior neural fold homeobox
, PKR-associated protein X
, PKR-associating protein X
, interferon-inducible double stranded RNA-dependent protein kinase activator A
, protein activator of the interferon-induced protein kinase
, protein kinase, interferon-inducible double stranded RNA-dependent activator
, double-stranded RNA-binding protein A
, interferon-inducible double stranded RNA-dependent protein kinase activator A homolog A
, interferon-inducible double stranded RNA-dependent protein kinase activator A homolog B
, retina and anterior neural fold homeobox protein
, retinal homeobox protein Rx
, Rx/rax homeoprotein
, eyeless 1