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Data show that the ketone body metabolizing enzymes BDH1, BDH2 (show BDH2 Proteins), OXCT1 (show OXCT1 Proteins) and ACAT1 (show ACAT1 Proteins) were expressed at the mRNA and protein level in all glioma cell lines.
hydrogen peroxide-induced apoptosis was attenuated by Bdh1 overexpression.
High BDH1 expression is Associated with Dilated Cardiomyopathy.
This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described.
3-hydroxybutyrate dehydrogenase, type 1
, D-beta-hydroxybutyrate dehydrogenase, mitochondrial
, D-beta-hydroxybutyrate dehydrogenase, mitochondrial-like
, (R)-3-hydroxybutyrate dehydrogenase
, 3-hydroxybutyrate dehydrogenase (heart, mitochondrial)
, short chain dehydrogenase/reductase family 9C, member 1
, b-hydroxybutyrate dehydrogenase