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Data show that the ketone body metabolizing enzymes BDH1, BDH2, OXCT1 and ACAT1 were expressed at the mRNA and protein level in all glioma cell lines.
hydrogen peroxide-induced apoptosis was attenuated by Bdh1 overexpression.
High BDH1 expression is Associated with Dilated Cardiomyopathy.
This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described.
3-hydroxybutyrate dehydrogenase, type 1
, D-beta-hydroxybutyrate dehydrogenase, mitochondrial
, D-beta-hydroxybutyrate dehydrogenase, mitochondrial-like
, (R)-3-hydroxybutyrate dehydrogenase
, 3-hydroxybutyrate dehydrogenase (heart, mitochondrial)
, short chain dehydrogenase/reductase family 9C, member 1
, b-hydroxybutyrate dehydrogenase