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miR (show MLXIP Proteins)-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma
this studies demonstrate that HMGCS2 functions as a transcriptional factor that binds to peroxisome proliferator-activated receptor alpha (PPARalpha (show PPARA Proteins)), resulting in Src (show SRC Proteins) expression and activation in a metabolically independent manner
HMGCS2 shares with ketone bodies common features in autophagic clearance of APP (show APP Proteins), suggesting that ketone bodies play an important role in HMGCS2 regulation of the autophagy.
High expression of either HSD17B2 or HMGCS2 predicted poor susceptibility of rectal cancer to preoperative chemoradiotherapy.
FABP7 (show FABP7 Proteins) and HMGCS2 may have roles in apocrine differentiation categorizing apocrine carcinoma of the breast
In Fe-S cluster-deficient muscles, results show a dramatic up-regulation of the ketogenic enzyme HMGCS2 and the secreted protein FGF21 (fibroblast growth factor 21 (show FGF21 Proteins)).
An alternative transcript of HMGCS2 carrying a deletion of exon 4, and two alternative transcripts of HMGCL (show HMGCL Proteins) with deletions of exons 5 and 6, and exons 5, 6 and 7, respectively, were detected.
Human HMGCS2 regulates mitochondrial fatty acid oxidation and FGF21 (show FGF21 Proteins) expression
Ketogenesis is an undesirable metabolic characteristic of the proliferating cell, which is down-regulated through c-Myc (show MYC Proteins)-mediated repression of the key metabolic gene HMGCS2.
It is a key enzyme for catalyzing b-hydroxybutyric acid production, and observed in early Alzheimer's disease.And a hepatic inflammatory factor, IL-6 (show IL6 Proteins) enhances ketogenesis through HMGCS2 signaling activation by p38 (show CRK Proteins)/NF-kB p65.
Using in vitro ketosis model by glucose starvation, studied inhibition of ketosis by momilactone B. Found momilactone B could regulate the angiopoietin-like-3 (ANGPTL3 (show ANGPTL3 Proteins))-lipoprotein lipase (LPL (show LPL Proteins))pathway, and suppressed the expression of HMGCS2 through the increased expression of STAT5b (show STAT5B Proteins).
HMGCS2 was identified as a major down-regulated protein in colonic crypts isolated from Keratin 8 (show KRT8 Proteins)-/- mice.
The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)
, HMG-CoA synthase
, hydroxymethylglutaryl-CoA synthase, mitochondrial
, 3-hydroxy-3-methylglutaryl coenzyme A synthase
, 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
, hydroxymethylglutaryl-CoA synthase 2
, hydroxymethylglutaryl-CoA synthase, mitochondrial-like
, hydroxymethylglutaryl-CoA synthase
, hydroxymethylglutaryl-coa synthase
, putative hydroxymethylglutaryl-CoA synthase family protein
, 3-HYDROXY-3-METHYLGLUTARYL-CoA SYNTHASE 2
, 3-hydroxy-3-methylglutaryl-CoA synthase 2
, 3-hydroxy-3-methylglutary-Coenzyme A synthase 2