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Human ATG7 Protein expressed in Wheat germ - ABIN1345982
Han, Hou, Goldstein, Stolz, Watkins, Rabinowich: A Complex between Atg7 and Caspase-9: A NOVEL MECHANISM OF CROSS-REGULATION BETWEEN AUTOPHAGY AND APOPTOSIS. in The Journal of biological chemistry 2014
miR (show MLXIP Proteins)-210 inhibits autophagy via silencing of ATG7.
miR (show MLXIP Proteins)-106a suppresses tumor cells death in colorectal cancer through targeting ATG7.
PSMD10/gankyrin (show PSMD10 Proteins) has a role in inducing autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression
the ATG5 (show ATG5 Proteins)-ATG7-NCOA4 (show NCOA4 Proteins) autophagic pathway has a role in ferroptosis
knockdown of autophagy genes ATG5 (show ATG5 Proteins) or ATG7 resulted in reduced hematopoietic stem/progenitor cell frequencies in vitro as well as in vivo.
Nine of the 32 (28.1%) iCCA (show PRRT2 Proteins) patients had gene mutations at chromosome 3p, totaling 11 mutations across five genes. Those included five (15.6%) BAP1 (show RNF2 Proteins) mutations, two each (6.3%) of CACNA2D3 (show CACNA2D3 Proteins) and RASSF1 (show RASSF1 Proteins) mutations, and one each (3.1%) of ATG7 and PLCD1 (show PLCD1 Proteins) mutations. Six (18.8%) cases had concurrent loss of chromosome 3p and gene mutations.
knockdown of ATG7 results in decreased glycolysis and increased flux of labeled carbons through the mitochondrial tricarboxylic acid cycle.
SNP rs11706903 in ATG7 was not associated with systemic lupus erythematosus I Chinese Han population.
low serum ATG7 is associated with ulcerative colitis
The U2AF35 (show U2AF1 Proteins)(S34F) mutation alters interaction with CFIm59 (show CPSF7 Proteins), leading to increased use of a distal cleavage and polyadenylation site in the ATG7 pre-mRNA, decreasing levels of ATG7 protein and defective autophagy, ultimately leading to transformation.
Atg5 (show ATG5 Proteins)- and Atg7-dependent autophagy of dopaminergic neurons contributed to cellular and behavioral responses to morphine and may have implications for the future treatment of drug addiction.
Deletion Atg7 in pancreatic acinar cells was sufficient to induce strong acinar cell death associated with acute pancreatitis that later progressed to chronic pancreatitis.
A thiol-dependent process is being reported that may account for impaired autophagy during aging. This is through direct oxidation of key autophagy-related (Atg) proteins Atg3 (show ATG3 Proteins) and Atg7.
Atg7 regulates IL-6 (show IL6 Proteins) production via NF-kappaB (show NFKB1 Proteins) to modulate brain angiogenesis. These findings established Atg7 as a novel regulatory molecule contributing to angiogenesis in the brain.
Autophagy deficiency induced by RPE (show RPE Proteins)-specific deletion of Atg5 (show ATG5 Proteins) or Atg7 predisposes but does not necessarily drive the development of AMD (show AMD1 Proteins)-like phenotypes or retinal degeneration.
ATG7 has a role in autophagy deficiency in macrophages that may contribute to the progression of metabolic syndrome associated with lipid injury and colitis
ATG proteins ATG5 (show ATG5 Proteins) and ATG7 may be required for phagosome maturation under some conditions, but are not universally required for this process
Autophagy and tumorigenesis were not increased in Atg7(+/-) mice kept in social isolation and fed OID. Thus, social isolation may increase breast cancer risk by inducing autophagy, independent of changes in body weight.
ATG7, but not ATG13 (show ATG13 Proteins) or ULK1 (show ULK1 Proteins) has a role in functional autophagy in glioblastoma development
This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes.
autophagy-related protein 7
, Autophagy-related protein 7
, ATG7 autophagy related 7 homolog
, ATG12-activating enzyme E1 ATG7
, ubiquitin activating enzyme E1-like protein
, ubiquitin-activating enzyme E1-like protein
, ubiquitin-like modifier-activating enzyme ATG7
, autophagy-related 7
, autophagy related 7 homolog
, potential E1-like Atg12p-Atg5p conjugation enzyme Atg7