Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Human ATG7 Protein expressed in Wheat germ - ABIN1345982
Han, Hou, Goldstein, Stolz, Watkins, Rabinowich: A Complex between Atg7 and Caspase-9: A NOVEL MECHANISM OF CROSS-REGULATION BETWEEN AUTOPHAGY AND APOPTOSIS. in The Journal of biological chemistry 2014
miR154 expression was significantly downregulated and negatively correlated with ATG7 expression in bladder cancer (BCa) tissues and cell lines. miR154 expression was associated with advanced T stage, lymphatic invasion, and distant metastasis. A xenograft study revealed that miR154 inhibited BCa cell growth in vivo and suppressed ATG7 expression.
ATG7 SNPs identified in myocardial infarction patients may alter the transcriptional activity of the ATG7 gene promoter and change ATG7 level, contributing to the AMI development as a rare risk factor.
Silencing of ATG7 downregulated MALAT1 and ATG7 reciprocally regulated each other by miR-200a.
miR-210 inhibits autophagy via silencing of ATG7.
miR-106a suppresses tumor cells death in colorectal cancer through targeting ATG7.
PSMD10/gankyrin has a role in inducing autophagy to promote tumor progression through cytoplasmic interaction with ATG7 and nuclear transactivation of ATG7 expression
the ATG5-ATG7-NCOA4 autophagic pathway has a role in ferroptosis
knockdown of autophagy genes ATG5 or ATG7 resulted in reduced hematopoietic stem/progenitor cell frequencies in vitro as well as in vivo.
Nine of the 32 (28.1%) iCCA patients had gene mutations at chromosome 3p, totaling 11 mutations across five genes. Those included five (15.6%) BAP1 mutations, two each (6.3%) of CACNA2D3 and RASSF1 mutations, and one each (3.1%) of ATG7 and PLCD1 mutations. Six (18.8%) cases had concurrent loss of chromosome 3p and gene mutations.
knockdown of ATG7 results in decreased glycolysis and increased flux of labeled carbons through the mitochondrial tricarboxylic acid cycle.
SNP rs11706903 in ATG7 was not associated with systemic lupus erythematosus I Chinese Han population.
The G allele of rs8154 was correlated with breast cancer patients poorer survival.
low serum ATG7 is associated with ulcerative colitis
The U2AF35(S34F) mutation alters interaction with CFIm59, leading to increased use of a distal cleavage and polyadenylation site in the ATG7 pre-mRNA, decreasing levels of ATG7 protein and defective autophagy, ultimately leading to transformation.
the inhibition of Atg7 appears to be a valid strategy to enhance chemosensitivity, and it could indeed improve outcomes in acute myeloid leukemia therapy.
Our data demonstrate that HOTAIR promotes the activation of autophagy in HCC cells by upregulating the expression of the autophagy-related genes ATG3 and ATG7.
Autophagy-related gene ATG7 was validated as a target of miR-17 seed family.
the upregulation of autophagy-related gene (Atg) and wingless/int1 (Wnt) signaling during BMP-2-mediated human osteoblastic differentiation, was examined.
Aldo was revealed to induce autophagy, as indicated by the increased conversion from microtubuleassociated protein 1A/1Blight chain 3 (LC3)I to LC3II, the increased expression levels of autophagyrelated gene 7 (Atg7) and the increased degradation of p62, which was accompanied by MC proliferation
PVT1 overexpression increased the expression of Atg7 and Beclin1 by targeting miR-186, which induced protective autophagy, thus promoting glioma vascular endothelial cell proliferation, migration, and angiogenesis. Therefore, PVT1 and miR-186 can provide new therapeutic targets for future anti-angiogenic treatment of glioma
findings revealed that HOTAIR regulates autophagy via the miR-20b-5p/ATG7 axis in hepatic I/R injury, which may serve as basis to develop novel therapeutic strategies to treat hepatic I/R injury.
Atg7(f/f) Tyr-Cre mice, in which autophagy-related 7 (Atg7) is conditionally deleted under the control of the tyrosinase promoter, are a model for accumulations of the autophagy adapter and substrate sequestosome-1/p62 in both neuronal and neuroepithelial cells.
our study demonstrated that miR-143 mediates oxidative stress-induced autophagy to enhance the survival of c-kit(+) CPCs by targeting Atg7, which will provide a complementary approach for improving cardiac progenitor cells (CPCs)-based heart repair
Atg5- and Atg7-dependent autophagy of dopaminergic neurons contributed to cellular and behavioral responses to morphine and may have implications for the future treatment of drug addiction.
Deletion Atg7 in pancreatic acinar cells was sufficient to induce strong acinar cell death associated with acute pancreatitis that later progressed to chronic pancreatitis.
A thiol-dependent process is being reported that may account for impaired autophagy during aging. This is through direct oxidation of key autophagy-related (Atg) proteins Atg3 and Atg7.
Atg7 regulates IL-6 production via NF-kappaB to modulate brain angiogenesis. These findings established Atg7 as a novel regulatory molecule contributing to angiogenesis in the brain.
Autophagy deficiency induced by RPE-specific deletion of Atg5 or Atg7 predisposes but does not necessarily drive the development of AMD-like phenotypes or retinal degeneration.
ATG7 has a role in autophagy deficiency in macrophages that may contribute to the progression of metabolic syndrome associated with lipid injury and colitis
ATG proteins ATG5 and ATG7 may be required for phagosome maturation under some conditions, but are not universally required for this process
Autophagy and tumorigenesis were not increased in Atg7(+/-) mice kept in social isolation and fed OID. Thus, social isolation may increase breast cancer risk by inducing autophagy, independent of changes in body weight.
ATG7, but not ATG13 or ULK1 has a role in functional autophagy in glioblastoma development
Atg7 is critical for the survival of midbrain dopaminergic (mDA) neurons in physiological condition. Atg7 is up-regulated when exposed to MPTP, but unlike in the control mice, chronic MPTP treatment did not lead to loss of mDA neurons in Atg7 conditional knockout mice. These results suggest that excessive Atg7-involved autophagy in the pathological condition has deleterious effects on the survival of mDA neurons.
It shows that AMBRA1, but not ATG7, plays a role in TCR-mediated control of glycolytic factors and mitochondrial mass, while both AMBRA1 and ATG7 are required for autolysosome formation.
Collectively, these data reveal that miR-20a inhibits autophagic response and promotes BCG survival in macrophages by targeting ATG7 and ATG16L1.
Beta-Atg7 (-/-) mice had proinsulin-containing sequestosome 1 (p62 [also known as SQSTM1])(+) aggregates in beta cells, indicating proinsulin is regulated by autophagy in vivo. Short-term bafilomycin-A1 treatment and ATG5/7 knockdown increased steady-state proinsulin and hormone precursor chromogranin A content. ATG5/7 knockdown also increased glucose- and non-fuel-stimulated insulin secretion.
gene deletion results in accumulation of RPE65 variant M450 in the retinal pigment epithelium
A conditional deletion of Atg7 in hepatocytes leads to hepatomegaly and in aged animals to liver tumors.
This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes.
autophagy-related protein 7
, Autophagy-related protein 7
, ATG7 autophagy related 7 homolog
, ATG12-activating enzyme E1 ATG7
, ubiquitin activating enzyme E1-like protein
, ubiquitin-activating enzyme E1-like protein
, ubiquitin-like modifier-activating enzyme ATG7
, autophagy-related 7
, autophagy related 7 homolog
, potential E1-like Atg12p-Atg5p conjugation enzyme Atg7