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We found the suicide-associated gene coexpression network. The reconstructed network consisted of 104 genes. Topological analysis showed that in total, CCK (show CCK Proteins), INPP1, DDC (show DDC Proteins), and NPY (show NPY Proteins) genes are the most fundamental hubs in the network
High INPP1 expression is associated with cancer aggressiveness.
results suggest that genetic variability at rs669838-IMPA2,rs4853694-INPP1, rs1732170-GSK3b and rs11921360-GSK3b genes is associated with a higher risk of attempting suicide in bipolar patients.
association study performed between the 5' regulatory region of the serotonin transporter (show SLC6A4 Proteins) gene (5-HTTLPR (show SLC6A4 Proteins)), the inositol polyphosphate 1-phosphatase gene (INPP1) and bipolar disorder using our sample of proband/parent trios
Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor.
This gene encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate.
, inositol polyphosphate 1-phosphatase
, inositol polyphosphate-1-phosphatase
, inositol polyphosphate 1-phosphatase-like