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The increased NO production with increased expression of iNOS (show NOS2 Proteins) and ncNOS (show NOS1 Proteins) may contribute to the pathological and physiological features of UVB-induced erythema and skin inflammation.
Data describe for the first time the expression pattern of the NANOS2 gene in human tissues and show that it is testis specific (show THEG Proteins). We found that NANOS2 protein is present in prenatal germ cells and at later stages in spermatogenesis.
DND1 (show DND1 Proteins) interacts with NANOS2 to load unique RNAs into the CCR4 (show CCR4 Proteins)-NOTdeaden complex; this interaction is mediated by the zinc finger domain of NANOS2, which is essential for its association with target RNAs; DND1 (show DND1 Proteins) is an essential partner for NANOS2 that leads to the degradation of specific RNAs in male germ cell development
show that Nanos2, an evolutionarily conserved RNA-binding protein, works with other cellular messenger ribonucleoprotein (mRNP) components to ensure the primitive status of spermatogonial stem cells
Our experiments identified that miR-34c may promote meiosis process by interacting with Nanos2 leading up-regulation of Stra8 in mouse spermatogonial stem cells.
NANOS2 is not merely a suppressor of meiosis, but instead plays pivotal roles in the sexual differentiation of male germ cells.
results strongly suggest that RHOX13 expression is regulated at a posttranscriptional step by direct interaction of NANOS2 with Rhox13 mRNA to suppress translation.
NANOS2 mutant lacking these first 10 amino acids fails to bind CCR4 (show CCR4 Proteins)-NOT deadenylation complex which is essential for male germ cell development.
we suggest that NANOS2 acts downstream of GDNF signaling to maintain undifferentiated state of spermatogonial stem cells.
Nanos2 promotes male germ cell differentiation, while simultaneously suppressing a female program.
Nanos2 is continuously expressed in male germ cells from fetal gonocytes to postnatal spermatogonial stem cells.
NANOS2/CCR4 (show CCR4 Proteins)-NOT complex has deadenylase activity in vitro, and some of the RNAs implicated in meiosis interact with NANOS2 and are accumulated in its absence.
The nanos2 3'UTR is essential for the selective RNA retention in the small micromeres.[Nanos2]
The acquisition and maintenance of multipotency in the small micromere lineage requires nanos, which may function in part by repressing the cell cycle and regulating other multipotency factors such as vasa (show DDX4 Proteins).
Overexpression of Nanos2 significantly downregulated meiosis-related genes, including Stra8 and Scp3 (show SYCP3 Proteins), which induced inhibition of meiosis.
cytokine-inducible enzmyme involved in nitric oxide (NO) production
, nanos homolog 2
, nanos homolog 2 (Drosophila)
, nanos 2
, nanos2 protein