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High TGIF-1 expression is associated with fetal growth restriction.
Tgifs regulate ciliogenesis and suggests that Evi5l mediates at least part of this effect.
Knockdown of TGIF1 resulted in decreased protein expression of HOXD10 (show HOXD10 ELISA Kits) and increased resistance to colistin cytotoxicity in renal cells.
Data show that the silencing of TG-interacting factor (TGIF) inhibited A549 lung cancer cell proliferation, growth of tumor xenograft in vivo, and arrested the cell cycle in the G1 phase.
we suggest that TGIF (show IL10 ELISA Kits) plays an important role in low-dose arsenic-induced malignant transformation of HaCaT cells, which is regulated by c-Src (show SRC ELISA Kits)/EGFR (show EGFR ELISA Kits)/AKT (show AKT1 ELISA Kits)/FOXO3A (show FOXO3 ELISA Kits) pathway and redox signaling.
Corneal fibroblasts demonstrate the expression of TGIF1 and TGIF2 (show TGIF2 ELISA Kits) transcription factors. These transcriptional repressors are critical, at least partially, in mediating the antifibrotic effect of vorinostat in the cornea.
Our results suggested that elevated expression of TGIF (show IL10 ELISA Kits) was involved in lung carcinogenesis.
our study demonstrated the oncogenic role of TGIF1 in NSCLC, and TGIF1 might be a therapeutic target for non-small cell lung cancer .
c-Src (show SRC ELISA Kits)/AKT (show AKT1 ELISA Kits) is the upstream signaling that regulates TGIF (show IL10 ELISA Kits)-induced Nox4 (show NOX4 ELISA Kits) activation and subsequent superoxide production.
TGIF1 has a role as a negative regulator of MLL (show MLL ELISA Kits)-rearranged acute myeloid leukemia (show BCL11A ELISA Kits)
loss of Tgif1 causes axial patterning defects that are enhanced by mutations in Tgif2 (show TGIF2 ELISA Kits)
Tgif2 (show TGIF2 ELISA Kits) participates in photoreceptor cell differentiation in the early stages of retinal development and regulates proper subretinal localization of the cone photoreceptors.
Tgif1 counterbalances the activity of core pluripotency factors, Oct4, Sox2, and Nanog, in mouse embryonic stem cells.
Tgif1 suppresses stem cell self-renewal.
The identification and characterization of the Tgif mutant supports the role of TGFbeta (show TGFB1 ELISA Kits) signalling in the development of chronic OM.
Tgif1 mutation in mouse contributes to Holoprosencephaly pathogenesis due to disruption of the Shh (show SHH ELISA Kits) pathway
TGIF1 plays a role in TNF-alpha (show TNF ELISA Kits)- and radiation-induced inflammation and it could be a target in limiting this event in the vascular compartment
TGF-beta (show TGFB1 ELISA Kits)/Smad (show SMAD1 ELISA Kits) co-repressor TGIF1 plays a role in radiation-induced normal tissue damage by a Smad (show SMAD1 ELISA Kits)-independent mechanism.
Data suggest that in the absence of Tgif1, a persistent increase in TGFbeta (show TGFB1 ELISA Kits) responsive transcription and a reduced ability to deal with hyperoxic stress result in premature senescence in primary MEFs.
Tgif1 expression and regulation of TGFbeta (show TGFB1 ELISA Kits) signaling are implicated in the function of several types of stem cells, but this is the first demonstration that this regulatory network is necessary for regeneration of neurons.
Tgif is necessary for normal initiation of genes that control RA synthesis and degradation, resulting in defects in RA-dependent central nervous system patterning in Tgif-depleted embryos.
The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005
5'-TG-3'-interacting factor 1
, TALE homeobox TG-interacting factor
, homeobox protein TGIF1
, transforming growth factor-beta-induced factor
, izumo sperm-egg fusion protein 1
, oocyte binding/fusion factor
, sperm-specific protein Izumo
, TALE family homeobox
, TG interacting factor 1
, TG interacting factor
, TGFB-induced factor (TALE family homeobox)
, avian knotted-related protein
, homeobox protein AKR
, homeodomain protein AKR
, TG-interacting factor
, TGFB-induced factor homeobox 1
, TG-interacting homeobox protein
, TGFB induced factor homeobox 1 S homeolog