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Overexpression of CELF2 could reverse miR-615-3p's oncogenic functions.
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CUG-BP2 binds to AU-rich motifs found in the COX-2 mRNA 3'-UTR.
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Study provides evidence for a generalized position- dependent activity of CELF2 in splicing that can be used to predict its consequence on alternative splicing in a cell-type independent manner.
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These data suggest an interplay between CELF2 and hnRNP C as the mechanistic basis for activation-dependent alternative splicing of TRAF3 exon 8.
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Haplotype-dependent allele-specific methylation of CELF2 gene is associated with neurological disorders.
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CUGBP2 expression at the messenger RNA (mRNA) level was 2.2-fold lower and could be associated with high chemoresistance and early dissemination of pancreatic cancer.
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the genetic variant rs3740194 in CELF2 gene might be a valuable predictor for NPC prognosis
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Data show miR95 expression level positively related to glioma grade and its downregulation affects proliferation, invasion and apoptosis by targeting CELF2. MiR95 is identified as a putative therapeutic target and CELF2 as a potential tumor suppressor.
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a widespread role for the JNK-CELF2 axis in controlling splicing during T-cell activation, including a specific role in propagating JNK signaling.
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The A allele of rs2242451 in CUGBP2 might decrease Alzheimer disease risk in the Chinese Han population.
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novel mechanisms for CELF2 regulation that may broadly impact CELF2 expression across diverse cell types.
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There was evidence of association for recently-reported late-onset Alzheimer's disease risk loci, including BIN1 and CLU and CUGBP2 with APOE.
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Alternative splicing of LEF1 exon 6 is regulated during pre-TCR signaling in thymic development and in response to activation of the JSL1 T-cell line and this is driven by the activity of CELF2.
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results indicate the occurrence of a mis-splicing event in myotonic dystrophy type 1 that is induced neither by a loss of muscleblind-like 1 (MBNL1) function nor by a gain of CUGBP1
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BRUNOL3 appears to be an important factor for thymus development and is therefore a candidate gene for the thymus hypoplasia/aplasia seen in partial monosomy 10p patients.
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Determination of ETR-3 protein domains required for RNA splicing.
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data suggest that CUGBP2 is a critical regulator of the apoptotic response to genotoxic injury in breast cancer cells
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Lipopolysaccharide inhibition of CUGBP2 is a prostaglandin-dependent mechanism.
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Developmental upregulation of apoB mRNA editing from approximately 3% to 88% begins with decreased levels of inhibitory CUG binding protein 2 (CUGBP2) expression.
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CUGBP2 overrides HuR and suppresses COX-2 mRNA translation.
