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This neuronal DIRAS1 gene with a proposed role in cholinergic transmission provides not only a candidate for human myoclonic epilepsy but also insights into the disease etiology, while establishing a spontaneous model for future intervention studies and functional characterization.
Results show that DIRAS1 is frequently methylated in human colorectal cancer and the expression of DIRAS1 is silenced by promoter region methylation.
DiRas1 expression inhibits malignant features of cancers in part by nonproductively binding to SmgGDS (show RAP1GDS1 Proteins) and inhibiting the binding of other small GTPases to SmgGDS (show RAP1GDS1 Proteins)
DIRAS1 downregulation is associated with esophageal squamous cell carcinoma metastasis.
a novel Ras-related protein (show RASD1 Proteins) and potential neural tumor suppressor (RIG)
diras1a and diras1b enhanced Rac1 activity.
DIRAS1 belongs to a distinct branch of the functionally diverse Ras (see HRAS\; MIM 190020) superfamily of monomeric GTPases.
GTP-binding protein Di-Ras1
, distinct subgroup of the Ras family member 1
, ras-related inhibitor of cell growth
, small GTP-binding tumor suppressor 1
, DIRAS family, GTP-binding RAS-like 1