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Results show that DIRAS1 is frequently methylated in human colorectal cancer and the expression of DIRAS1 is silenced by promoter region methylation.
DiRas1 expression inhibits malignant features of cancers in part by nonproductively binding to SmgGDS (show RAP1GDS1 Proteins) and inhibiting the binding of other small GTPases to SmgGDS (show RAP1GDS1 Proteins)
we provide novel insights into the heterogeneous genomic landscape of relapsing chronic lymphocytic leukemia and report recurrent mutations in a "hotspot" region of RPS15
Study shows that ribosomal protein s15 is a key pathogenic LRRK2 substrate in Drosophila and human neuron Parkinson's disease models.
RPL37 (show RPL37 Proteins), RPS15 (show RPS15 Proteins) and RPS20 (show RPS20 Proteins) regulate the Mdm2 (show MDM2 Proteins)-p53 (show TP53 Proteins)-MdmX (show MDM4 Proteins) network but employ different mechanisms to do so.
DIRAS1 downregulation is associated with esophageal squamous cell carcinoma metastasis.
a novel Ras-related protein (show RASD1 Proteins) and potential neural tumor suppressor (RIG)
diras1a and diras1b enhanced Rac1 activity.
DIRAS1 belongs to a distinct branch of the functionally diverse Ras (see HRAS\; MIM 190020) superfamily of monomeric GTPases.
40S ribosomal protein S15
, homolog of rat insulinoma
, insulinoma protein
, GTP-binding protein Di-Ras1
, distinct subgroup of the Ras family member 1
, ras-related inhibitor of cell growth
, small GTP-binding tumor suppressor 1
, DIRAS family, GTP-binding RAS-like 1