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Relevance Score | uniqeid | Catalogue Id | Detection Method | Sample Type | Analytical Method | Detection Range | Sensitivity | Supplier | References | Quantity | Price |
---|---|---|---|---|---|---|---|---|---|---|---|
6 | element-ABIN5520476 | ABIN5520476 | Colorimetric
(Pre-coated) |
Plasma, Serum, Tissue Homogenate | Quantitative Sandwich ELISA | 78.125-5000 pg/mL | 46.875 pg/mL | Log in to see | 96 tests | $525.20 | |
5 | element-ABIN4970232 | ABIN4970232 | Colorimetric
(Pre-coated) |
Quantitative Sandwich ELISA | 78.125-5000 pg/mL | 46.875 pg/mL | Log in to see | 96 tests | $653.82 |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins. {ECO:0000255|HAMAP-Rule:MF_03004}.
eukaryotic translation initiation factor 3 subunit E , eukaryotic translation initiation factor 3, subunit 6 48kDa , eukaryotic translation initiation factor 3 subunit 6 , eukaryotic translation initiation factor 3, subunit 6 , eukaryotic translation initiation factor 3 subunit E-A , Eukaryotic translation initiation factor 3 subunit 6-A , eukaryotic translation initiation factor 3 subunit E-B , Eukaryotic translation initiation factor 3 subunit 6-B , eukaryotic translation initiation factor 3, subunit E , eIF-3 p48 , eukaryotic translation initiation factor 3 subunit E-like , eukaryotic translation initiation factor 3, subunit 6 (48kD) , mammary tumor-associated protein INT6 , murine mammary tumor integration site 6 (oncogene homolog) , viral integration site protein INT-6 homolog , MMTV integration site 6 , mammary tumor integration site 6 , mammary tumor-associated protein INT-6 , viral integration site protein INT-6 , Eukaryotic translation initiation factor 3 subunit 6
GENE ID | SPECIES |
---|---|
697622 | Macaca mulatta |
394752 | Xenopus (Silurana) tropicalis |
398503 | Xenopus laevis |
692936 | Bombyx mori |
734371 | Xenopus laevis |
100063841 | Equus caballus |
100156671 | Sus scrofa |
100173055 | Pongo abelii |
100185058 | Ciona intestinalis |
100413143 | Callithrix jacchus |
3646 | Homo sapiens |
475070 | Canis lupus familiaris |
534165 | Bos taurus |
16341 | Mus musculus |
299872 | Rattus norvegicus |
420272 | Gallus gallus |
100196666 | Salmo salar |
172959 | Caenorhabditis elegans |