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Results solve the structure of a complex resulting from interaction between protein fragments of human NUFIP1 and its cofactor ZNHIT3 (show ZNHIT3 Proteins), and emphasize their imbrication. Also, it seems that the complexes involving NUFIP1, ZNHIT3 (show ZNHIT3 Proteins), and SNU13 (show NHP2L1 Proteins) share strong structural similarities between human and yeast, suggesting that the initial steps of the box C/D snoRNP assembly process are conserved among species.
NUFIP is associated with preinitiation complexes, open transcription complexes, and elongation complexes and facilitates ATP-dependent dissociation of hyperphosphorylated pol II from open transcription complexes in vitro
This gene encodes a nuclear RNA binding protein that contains a C2H2 zinc finger motif and a nuclear localization signal. This protein is associated with the nuclear matrix in perichromatin fibrils and, in neurons, localizes to the cytoplasm in association with endoplasmic reticulum ribosomes. This protein interacts with the fragile X mental retardation protein (FMRP), the tumor suppressor protein BRCA1, upregulates RNA polymerase II transcription, and is involved in box C/D snoRNP biogenesis. A pseudogene of this gene resides on chromosome 6q12.
nuclear fragile X mental retardation-interacting protein 1
, nuclear fragile X mental retardation protein interacting protein 1
, nuclear fragile X mental retardation-interacting protein 1-like
, nuclear FMRP-interacting protein 1
, nuclear FMRP interacting protein