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MAT2A expression is upregulated through mRNA stabilization upon SAM (show TTN Proteins) depletion.
Increased MAT2A expression is associated with recurrence in hepatocellular carcinoma.
High MAT2A expression is associated with tamoxifen-resistant breast cancer.
METTL16 (show METTL16 Proteins) that controls MAT2A intron retention in response to intracellular SAM (show TTN Proteins) levels; splicing of the MAT2A retained intron is rapidly induced upon Met depletion, and this effect requires a conserved hairpin which is a METTL16 (show METTL16 Proteins) m6A (show GPM6A Proteins) substrate.
S-adenosyl-L-methionine (show AS3MT Proteins) diminishes hepatitis C virus expression by altering MAT1A (show MAT1A Proteins)/2A signaling in hepatocytes.
methionine adenosyltransferase II alpha (MAT2A), and the arginine methyltransferase, PRMT5 (show PRMT5 Proteins), as vulnerable enzymes in cells with MTAP (show MTAP Proteins) deletion.
acet (show EP300 Proteins)ylation decreased in hepatocellular cancer
The data presented here support the conclusion that rare genetic variants in MAT2A predispose individuals to thoracic aortic disease.
Results suggest that MAT2A is downregulated in cancer tissues of renal cell carcinomas patients and has function of tumor suppressor though repressing the expression of heme oxygenase-1 (show HMOX1 Proteins).
Liver-specific isoenzyme MAT1A (show MAT1A Proteins) is genetically linked with an inborn metabolic disorder of hypermethioninemia, as well as a ubiquitously expressed isoenzyme MAT2A, whose enzymatic activity is regulated by an associated subunit MAT2B (show MAT2B Proteins).
SIRT1 (show SIRT1 Proteins) knock-out embryos display reduced Mat2a expression and histone methylation and are sensitive to maternal methionine restriction-induced lethality, whereas maternal methionine supplementation increases the survival of SIRT1 (show SIRT1 Proteins) knock-out newborn mice.
P300 (show NOTCH1 Proteins) acetylates MAT IIalpha at lysine residue 81 and destabilizes MAT IIalpha by promoting its ubiquitylation and subsequent proteasomal degradation.
MATIIalpha represses the expression of cyclooxygenase 2 (COX-2 (show PTGS2 Proteins)), encoded by Ptgs2 (show PTGS2 Proteins), by specifically interacting with histone H3K9 methyltransferase SETDB1 (show SETDB1 Proteins).
Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf (show MAF Proteins) oncoprotein
MAT2A and MAT2beta (show MAT2B Proteins) genes are induced during hepatic stellate cell activation
up-regulation of MAT2A also provides a growth advantage and s-adenosylmethionine and methylthioadenosine can block mitogenic signaling in colon cancer cells.
The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes.
methionine adenosyltransferase II, alpha
, S-adenosylmethionine synthetase isoform type-2-like
, MAT 2
, S-adenosylmethionine synthase isoform type-2
, adoMet synthase 2
, adoMet synthetase 2
, methionine adenosyltransferase 2
, S-adenosylmethionine synthetase isoform type-2
, non-hepatic-type S-adenosylmethionine synthetase