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anti-Human Amphiregulin Antibodies:
anti-Mouse (Murine) Amphiregulin Antibodies:
anti-Rat (Rattus) Amphiregulin Antibodies:
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Human Polyclonal Amphiregulin Primary Antibody for WB - ABIN610556
Chen, Parsons, Brautigan: Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts. in The Journal of biological chemistry 1994
Show all 2 Pubmed References
Human Polyclonal Amphiregulin Primary Antibody for IHC, IHC (p) - ABIN4280428
Barton, DAmato, Gordon, Lind, Spoelstra, Babbs, Heinz, Elias, Jedlicka, Jacobsen, Richer: Multiple molecular subtypes of triple-negative breast cancer critically rely on androgen receptor and respond to enzalutamide in vivo. in Molecular cancer therapeutics 2015
Human Amphiregulin Primary Antibody for ELISA - ABIN638842
Oliveras-Ferraros, Cufí, Queralt, Vazquez-Martin, Martin-Castillo, de Llorens, Bosch-Barrera, Brunet, Menendez: Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells. in British journal of cancer 2012
Human Polyclonal Amphiregulin Primary Antibody for IF (p), IHC (p) - ABIN704996
Jiang, Song, Li, Guo, Wu, Li, Guo, Shi, Bi, Jonas: Amphiregulin Antibody and Reduction of Axial Elongation in Experimental Myopia. in EBioMedicine 2017
Results show that AREG expression is up-regulated in gastric tumor and its co-expression with TROP2 (show TACSTD2 Antibodies) protein is associated with TNM (show ODZ1 Antibodies) stage, tumor size, lymph node metastases, and distant metastases.
secretion of IL-13 (show IL13 Antibodies) and amphiregulin suggests Intrahepatic Innate lymphoid cells may be recruited to promote resolution and repair and thereby they may contribute to ongoing fibrogenesis in liver disease.
EGF (show EGF Antibodies)-AREG interplay in airway basal cell stem/progenitor cells is one of the mechanisms that mediates the interconnected pathogenesis of all major smoking-induced lesions in the human airway epithelium.
AREG expression may be useful for identifying CRTC1 (show CRTC1 Antibodies)-MAML2 (show MAML2 Antibodies)-positive mucoepidermoid carcinomas and as a marker for favorable prognosis.
Amphiregulin enhances VEGF-A (show VEGFA Antibodies) production in human chondrosarcoma cells and promotes angiogenesis by inhibiting miR (show MLXIP Antibodies)-206 via FAK (show PTK2 Antibodies)/c-Src (show SRC Antibodies)/PKCdelta (show PKCd Antibodies) pathway.
Amphiregulin plays an important role in lung neoplasm resistance to amrubicinol
EREG (show EREG Antibodies) and AREG are strongly regulated by methylation, and their expression is associated with CIMP status and primary tumour site.
These findings demonstrate the posttranslational regulation of Foxp3 (show FOXP3 Antibodies) expression by AREG in cancer patients through AREG/EGFR (show EGFR Antibodies)/GSK-3beta (show GSK3b Antibodies) signaling, which could lead to Foxp3 (show FOXP3 Antibodies) protein degradation in Treg cells and a potential therapeutic target for cancer treatment.
blocking soluble amphiregulin with a neutralizing antibody also significantly increased apoptotic cell death of HepG2 cells due to treatment with methyl methanesulfonate, cisplatin, or a recombinant p53 (show TP53 Antibodies) adenovirus, suggesting that the function of amphiregulin involved in inhibiting apoptosis may be a common mechanism by which hepatoma cells escape from stimulus-induced apoptosis
Low AREG expression is associated with gastric cancer.
activated alveolar macrophages also exerted a protective effect on the lung tissues by producing high-level amphiregulin in lipopolysaccharide-induced acute lung injury
AREG overexpression in osteoblasts induces a transient high bone mass phenotype in the trabecular compartment of the appendicular skeleton by a growth-related, non-cell autonomous mechanism
AREG-silenced keratinocytes plays an important role in regulation cell proliferation.
Hepatic CD206 (show MRC1 Antibodies)-positive macrophages express amphiregulin to promote the immunosuppressive activity of regulatory T cells in HBV infection.
Areg may have a role in classically activated macrophages
After activation with IL-33 (show IL33 Antibodies), expression of AREG is a dominant functional signature of gut (show GUSB Antibodies)-associated IL-33 (show IL33 Antibodies)-dependent group 2 innate lymphoid cells. The frequency and number of AREG-expressing ILC2s increases following intestinal injury.
AR induces hHSC fibrogenic activity via multiple mitogenic signaling pathways, and is upregulated in murine and human NASH (show SAMSN1 Antibodies), suggesting that AR antagonists may be clinically useful anti-fibrotics in NAFLD (show TSC2 Antibodies).
hormones and/or factors in addition to E that upregulate AREG can promote mammary gland development and have the potential to affect breast cancer risk associated with pubertal mammary gland development
Our data show that AREG is essential for ultraviolet therapy-induced contact hypersensitivity suppression.
Pre-maturation with cAMP modulators in conjunction with EGF (show EGF Antibodies)-like peptides during in vitro maturation enhances mouse oocyte developmental competence.
LH and AREG decrease BNP (show BNC2 Antibodies) and CNP (show NPPC Antibodies) production in granulosa cells and down-regulate NPR2 (show NPRL2 Antibodies) expression in cumulus cells, which together decreased oocyte cGMP to levels that permit meiotic resumption.
cloning the complete coding region; comparison of endometrial amphiregulin mRNA expression in Meishan and White composite pigs
Amphiregulin co-operates with bone morphogenetic protein 15 (show BMP15 Antibodies) to increase bovine oocyte developmental competence.
Data suggest that epidermal growth factor receptor (show EGFR Antibodies) B [ErbB (show EGFR Antibodies)] isoforms and their ligands (epidermal growth factor (show EGF Antibodies) [EGF (show EGF Antibodies)], amphiregulin [AREG], and neuregulin-1 (show NRG1 Antibodies) [NRG1 (show NRG1 Antibodies)]) are expressed in uteroplacental tissues in mid- and late-phases of pregnancy.
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype.
colorectum cell-derived growth factor
, schwannoma-derived growth factor
, amphiregulin (schwannoma-derived growth factor)
, amphiregulin long form
, amphiregulin B
, Schwannoma-derived growth factor