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|Antigen||Discoidin Domain Receptor tyrosine Kinase 1 (DDR1) Antibodies|
|Epitope||AA 1-416 Alternatives|
|Conjugate||This DDR1 antibody is un-conjugated Alternatives|
Immunoprecipitation (IP), ELISA, Western Blotting (WB)
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Product Details anti-DDR1 AntibodyTarget Details DDR1 Application Details Handling Images
Human DDR1 / CD167
Has cross-reactivity in ELISA with
|Characteristics||This antibody was obtained from a rabbit immunized with purified, recombinant Human DDR1 / CD167 (rh DDR1 / CD167, ABIN2003316 NP_001945.3, Met 1-Thr 416,.|
|Sterility||0.2 μm filtered|
|Immunogen||Recombinant Human DDR1 / CD167 protein (ABIN2003316)|
Target Details DDR1Product Details anti-DDR1 Antibody Application Details Handling Images back to top
|Alternative Name||DDR1 (DDR1 Antibody Abstract)|
|Background||Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK10/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK10/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway.|
|Pathways||RTK Signaling, Smooth Muscle Cell Migration|
Application DetailsProduct Details anti-DDR1 Antibody Target Details DDR1 Handling Images back to top
WB: 5-10 μg/mL
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human DDR1. The detection limit for Human DDR1 is approximately 0.00245 ng/well.
IP: 1-4 μg/mg of lysate
|Restrictions||For Research Use only|
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|Buffer||0.2 μm filtered solution in PBS with 5 % trehalose|
|Handling Advice||Avoid repeated freeze-thaw cycles.|
|Storage||4 °C,-20 °C,-80 °C|
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
|Expiry Date||12 months|
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