|Antigen||EPH Receptor A4 (EPHA4) Antibodies|
|Epitope||AA 279-472 Alternatives|
|Reactivity||Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This EPH Receptor A4 antibody is un-conjugated Alternatives|
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
|3 references available|
|Supplier||Log in to see|
Product Details anti-EPH Receptor A4 AntibodyTarget Details EPH Receptor A4 Application Details Handling References for anti-EPH Receptor A4 antibody (ABIN967994) Images
|Cross-Reactivity||Rat (Rattus), Human, Dog (Canine), Chicken|
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
|Purification||The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.|
|Immunogen||Mouse Sek aa. 279-472|
Target Details EPH Receptor A4Product Details anti-EPH Receptor A4 Antibody Application Details Handling References for anti-EPH Receptor A4 antibody (ABIN967994) Images back to top
|Alternative Name||EphA4 (EPHA4 Antibody Abstract)|
|Background||EphA4/Sek is a glycosylated protein tyrosine kinase of 986 amino acids and an apparent 110-130kDa molecular weight (molecular weight depends on glycocylation level of protein). EphA4 belongs to the Eph subfamily of receptor tyrosine kinases and like many others, it has an amino-terminal ligand-binding domain exposed to the extracellar matrix. EphA4 is predominantly expressed during development (this is common in the Eph family) and because of its mRNA localization, it has been proposed that it may play a role during segmentation of the hindbrain and mesoderm. Tyrosine 602 is a major autophosphorylation site of EphA4 and appears to be the docking site for the intracellular tyrosine kinase fyn.|
|Molecular Weight||110-130 kDa|
Application DetailsProduct Details anti-EPH Receptor A4 Antibody Target Details EPH Receptor A4 Handling References for anti-EPH Receptor A4 antibody (ABIN967994) Images back to top
Related Products: ABIN967389, ABIN968545
|Restrictions||For Research Use only|
HandlingProduct Details anti-EPH Receptor A4 Antibody Target Details EPH Receptor A4 Application Details References for anti-EPH Receptor A4 antibody (ABIN967994) Images back to top
|Buffer||Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store undiluted at -20°C.|
References for anti-EPH Receptor A4 antibody (ABIN967994)Product Details anti-EPH Receptor A4 Antibody Target Details EPH Receptor A4 Application Details Handling Images back to top
|Product cited in:||
Ellis, Kasmi, Ganju, Walls, Panayotou, Reith: "A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn." in: Oncogene, Vol. 12, Issue 8, pp. 1727-36, 1996
Becker, Gilardi-Hebenstreit, Seitanidou, Wilkinson, Charnay: "Characterisation of the Sek-1 receptor tyrosine kinase." in: FEBS letters, Vol. 368, Issue 2, pp. 353-7, 1995
Gilardi-Hebenstreit, Nieto, Frain, Mattéi, Chestier, Wilkinson, Charnay: "An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain." in: Oncogene, Vol. 7, Issue 12, pp. 2499-506, 1993
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