anti-Human EPH Receptor A4 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended EPH Receptor A4 Antibody (supplied by: Log in to see )

Antigen
EPH Receptor A4 (EPHA4) Antibodies
  • ephe
  • EPHA4
  • Ci-Eph1
  • sek
  • hek8
  • rtk1
  • tyr01
  • 2900005C20Rik
  • AI385584
  • Cek8
  • Hek8
  • Sek
  • Sek1
  • Tyro1
  • rb
  • HEK8
  • SEK
  • TYRO1
  • RGD1560587
  • EPH receptor A4
  • ephrin receptor epsilon
  • Eph receptor A4
  • EPHA4
  • ephe
  • epha4
  • Epha4
Epitope
AA 570-620
30
21
20
14
13
12
11
10
7
5
4
4
4
3
2
2
1
1
1
1
1
1
1
1
Reactivity
Human, Rat (Rattus)
157
73
36
10
10
10
7
7
7
6
4
4
2
2
2
2
2
1
1
1
Host
Rabbit
150
23
17
2
Clonality
Polyclonal
Conjugate
This EPH Receptor A4 antibody is un-conjugated
9
8
8
6
6
6
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
133
85
85
50
19
17
12
7
4
2
1
1
Options
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Catalog No. ABIN734123
$ 295.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN895462 IF (p) Alexa Fluor 488 Rabbit IgG AA 570-620 Log in to see Polyclonal
1 ABIN2812839 IF (p) Alexa Fluor 594 Rabbit IgG AA 570-620 Log in to see Polyclonal
1 ABIN895465 IF (p) Alexa Fluor 555 Rabbit IgG AA 570-620 Log in to see Polyclonal
1 ABIN895463 IF (p) Alexa Fluor 647 Rabbit IgG AA 570-620 Log in to see Polyclonal
1 ABIN895466 IF (p) Alexa Fluor 350 Rabbit IgG AA 570-620 Log in to see Polyclonal
1 ABIN734126 IF (p) Cy3 Rabbit IgG AA 570-620 Log in to see Polyclonal
1 ABIN734127 IF (p) Cy5 Rabbit IgG AA 570-620 Log in to see Polyclonal
1 ABIN734129 IF (p) Cy7 Rabbit IgG AA 570-620 Log in to see Polyclonal
1 ABIN734130 IF (p) FITC Rabbit IgG AA 570-620 Log in to see Polyclonal
1 ABIN734128 IF (p) Cy5.5 Rabbit IgG AA 570-620 Log in to see Polyclonal
1 ABIN5002005 IF (p) Alexa Fluor 750 Rabbit IgG AA 570-620 Log in to see Polyclonal
1 ABIN5002004 IF (p) Alexa Fluor 680 Rabbit IgG AA 570-620 Log in to see Polyclonal

General

Antigen EPH Receptor A4 (EPHA4) Antibodies
Epitope AA 570-620
(30), (21), (20), (14), (13), (12), (11), (10), (7), (5), (4), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Rat (Rattus)
(157), (73), (36), (10), (10), (10), (7), (7), (7), (6), (4), (4), (2), (2), (2), (2), (2), (1), (1), (1)
Host Rabbit
(150), (23), (17), (2)
Clonality
Polyclonal
Conjugate This EPH Receptor A4 antibody is un-conjugated
(9), (8), (8), (6), (6), (6), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(133), (85), (85), (50), (19), (17), (12), (7), (4), (2), (1), (1)
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Product Details anti-EPH Receptor A4 Antibody

Target Details EPH Receptor A4 Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human EphA4
Isotype IgG

Target Details EPH Receptor A4

Product Details anti-EPH Receptor A4 Antibody Application Details Handling Images back to top
Antigen
Alternative Name Eph Receptor A4 (EPHA4 Antibody Abstract)
Background

Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.

Subcellular location: Cytoplasm

Synonyms: SEK, HEK8, TYRO1, Ephrin type-A receptor 4, EPH-like kinase 8, EK8, Tyrosine-protein kinase TYRO1, Tyrosine-protein kinase receptor SEK, EPHA4

Gene ID 2043
UniProt P54764
Pathways RTK Signaling

Application Details

Product Details anti-EPH Receptor A4 Antibody Target Details EPH Receptor A4 Handling Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-EPH Receptor A4 Antibody Target Details EPH Receptor A4 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-EPH Receptor A4 Antibody Target Details EPH Receptor A4 Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-EPH Receptor A4 (EPHA4) (AA 570-620) antibody (ABIN734123) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti EP...
Immunohistochemistry (IHC) image for anti-EPH Receptor A4 (EPHA4) (AA 570-620) antibody (ABIN734123) Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti EPH receptor ...