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|Antigen||EPH Receptor B4 (EPHB4) Antibodies|
|Conjugate||This EPH Receptor B4 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|5 references available|
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Product Details anti-EPH Receptor B4 AntibodyTarget Details EPH Receptor B4 Application Details Handling References for anti-EPH Receptor B4 antibody (ABIN359817) Images
|Specificity||This antibody reacts to EphB4.|
|Purification||Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS|
|Immunogen||This antibody is generated from rabbits immunized with human recombinant EphB4 protein.|
Target Details EPH Receptor B4Product Details anti-EPH Receptor B4 Antibody Application Details Handling References for anti-EPH Receptor B4 antibody (ABIN359817) Images back to top
|Alternative Name||EPHB4 (EPHB4 Antibody Abstract)|
|Background||Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB4 binds to ephrin-B2 and plays an essential role in vascular development.Synonyms: Ephrin type-B receptor 4, HTK, TYRO11, Tyrosine-protein kinase TYRO11, Tyrosine-protein kinase receptor HTK|
|Gene ID||2050, 9606|
Application DetailsProduct Details anti-EPH Receptor B4 Antibody Target Details EPH Receptor B4 Handling References for anti-EPH Receptor B4 antibody (ABIN359817) Images back to top
ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-EPH Receptor B4 Antibody Target Details EPH Receptor B4 Application Details References for anti-EPH Receptor B4 antibody (ABIN359817) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-EPH Receptor B4 antibody (ABIN359817)Product Details anti-EPH Receptor B4 Antibody Target Details EPH Receptor B4 Application Details Handling Images back to top
Steinle, Meininger, Forough, Wu, Wu, Granger: "Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the phosphatidylinositol 3-kinase pathway." in: The Journal of biological chemistry, Vol. 277, Issue 46, pp. 43830-5, 2002
Suenobu, Takakura, Inada, Yamada, Yuasa, Zhang, Sakano, Oike, Suda: "A role of EphB4 receptor and its ligand, ephrin-B2, in erythropoiesis." in: Biochemical and biophysical research communications, Vol. 293, Issue 3, pp. 1124-31, 2002
Chiavarino, Crestoni, Fornarini: "Gas-phase dioxygen activation by binuclear manganese clusters." in: Chemistry (Weinheim an der Bergstrasse, Germany), Vol. 8, Issue 12, pp. 2740-6, 2002
Wilson, Riemer, Martindale, Schnupf, Boright, Cheung, Hardy, Schwartz, Scherer, Tsui, Miller, Koop: "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5." in: Nucleic acids research, Vol. 29, Issue 6, pp. 1352-65, 2001
Wilkinson: "Multiple roles of EPH receptors and ephrins in neural development." in: Nature reviews. Neuroscience, Vol. 2, Issue 3, pp. 155-64, 2001
ImagesProduct Details anti-EPH Receptor B4 Antibody Target Details EPH Receptor B4 Application Details Handling References for anti-EPH Receptor B4 antibody (ABIN359817) back to top