anti-Human ERBB4 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended ERBB4 Antibody (supplied by: Log in to see )

Antigen
V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) Antibodies
  • erbb4
  • si:ch211-227n20.1
  • Her4
  • c-erbB-4
  • HER4
  • p180erbB4
  • erb-b2 receptor tyrosine kinase 4
  • erb-b2 receptor tyrosine kinase 4a
  • v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
  • erb-b2 receptor tyrosine kinase 4 L homeolog
  • receptor tyrosine-protein kinase ErbB-4
  • ERBB4
  • erbb4a
  • erbb4
  • erbb4.L
  • Tsp_13582
  • Erbb4
Epitope
AA 460-510
42
35
34
34
20
18
17
17
15
13
12
12
7
6
6
5
4
4
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
364
180
148
7
5
4
3
3
3
3
2
2
2
1
1
Host
Rabbit
309
63
1
Clonality
Polyclonal
Conjugate
This ERBB4 antibody is un-conjugated
19
19
17
14
13
10
7
7
6
6
6
5
5
5
5
5
5
2
2
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
215
157
126
79
66
37
33
20
19
9
4
3
2
1
1
Options
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Catalog No. ABIN1714916
$ 306.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
4 ABIN1714927 IF (p) IHC (p) WB Rabbit IgG pTyr1258 Log in to see Polyclonal 0
1 ABIN800665 IF (p) FITC Rabbit IgG pTyr1162 Log in to see Polyclonal 0
1 ABIN800661 IF (p) Cy3 Rabbit IgG pTyr1162 Log in to see Polyclonal 0
1 ABIN800662 IF (p) Cy5 Rabbit IgG pTyr1162 Log in to see Polyclonal 0
1 ABIN800663 IF (p) Cy5.5 Rabbit IgG pTyr1162 Log in to see Polyclonal 0
1 ABIN800664 IF (p) Cy7 Rabbit IgG pTyr1162 Log in to see Polyclonal 0
1 ABIN800677 IF (p) Cy5 Rabbit IgG pTyr1188 Log in to see Polyclonal 0
1 ABIN800676 IF (p) Cy3 Rabbit IgG pTyr1188 Log in to see Polyclonal 0
1 ABIN800679 IF (p) Cy7 Rabbit IgG pTyr1188 Log in to see Polyclonal 0
1 ABIN800680 IF (p) FITC Rabbit IgG pTyr1188 Log in to see Polyclonal 0
1 ABIN800678 IF (p) Cy5.5 Rabbit IgG pTyr1188 Log in to see Polyclonal 0
1 ABIN743067 IF (p) Cy5 Rabbit IgG pTyr1284 Log in to see Polyclonal 0
1 ABIN743068 IF (p) Cy5.5 Rabbit IgG pTyr1284 Log in to see Polyclonal 0
1 ABIN743069 IF (p) Cy7 Rabbit IgG pTyr1284 Log in to see Polyclonal 0
1 ABIN743070 IF (p) FITC Rabbit IgG pTyr1284 Log in to see Polyclonal 0
1 ABIN743066 IF (p) Cy3 Rabbit IgG pTyr1284 Log in to see Polyclonal 0
1 ABIN878760 IF (p) Alexa Fluor 350 Rabbit IgG pTyr1162 Log in to see Polyclonal 0
1 ABIN878762 IF (p) Alexa Fluor 555 Rabbit IgG pTyr1162 Log in to see Polyclonal 0
1 ABIN878763 IF (p) Alexa Fluor 647 Rabbit IgG pTyr1162 Log in to see Polyclonal 0
1 ABIN878797 IF (p) Alexa Fluor 488 Rabbit IgG pTyr1188 Log in to see Polyclonal 0

General

Antigen V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) Antibodies
Epitope AA 460-510
(42), (35), (34), (34), (20), (18), (17), (17), (15), (13), (12), (12), (7), (6), (6), (5), (4), (4), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(364), (180), (148), (7), (5), (4), (3), (3), (3), (3), (2), (2), (2), (1), (1)
Host Rabbit
(309), (63), (1)
Clonality
Polyclonal
Conjugate This ERBB4 antibody is un-conjugated
(19), (19), (17), (14), (13), (10), (7), (7), (6), (6), (6), (5), (5), (5), (5), (5), (5), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(215), (157), (126), (79), (66), (37), (33), (20), (19), (9), (4), (3), (2), (1), (1)
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Product Details anti-ERBB4 Antibody

Target Details ERBB4 Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human HER4/ErbB4
Isotype IgG
Plasmids, Primers & others

Target Details ERBB4

Product Details anti-ERBB4 Antibody Application Details Handling Images back to top
Antigen
Alternative Name HER4/ErbB4 (ERBB4 Antibody Abstract)
Background

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration.

Subcellular location: Extracellular

Synonyms: HER4, ALS19, p180erbB4, Receptor tyrosine-protein kinase erbB-4, Proto-oncogene-like protein c-ErbB-4, Tyrosine kinase-type cell surface receptor HER4, ERBB4

Gene ID 2066
UniProt Q15303
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-ERBB4 Antibody Target Details ERBB4 Handling Images back to top
Application Notes IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-ERBB4 Antibody Target Details ERBB4 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-ERBB4 Antibody Target Details ERBB4 Application Details Handling back to top
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (AA 460-510) antibody (ABIN1714916) Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-HER4/ErbB4 Po...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4) (AA 460-510) antibody (ABIN1714916) Formalin-fixed and paraffin embedded rat kidney labeled with Rabbit Anti-HER4/ErbB4 P...