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Our findings suggest that ErbB4 splicing may regulate the pruning of excitatory synapses on parvalbumin (show PVALB Proteins) interneurons in the prefrontal cortex during adolescence.
the NRG-ErbB4 signaling pathway can potentially influence many functional systems throughout the brain of primates, and suggest that major sites of action are areas of the "corticolimbic" network
Widespread expression of ErbB4 receptor mRNAs was found throughout the telencephalon of juvenile and adult monkeys with in situ hybridization, with higher levels in grey matter compared to white matter.
ErbB (show EGFR Proteins) signaling control both convergent extension and head mesoderm migration during gastrulation.
The manipulation of NRG1 (show NRG1 Proteins)/ErbB4 signaling in the present study revealed that NRG1 (show NRG1 Proteins)/ErbB4 activity in the hippocampus is critical for learning and memory.
This study demonstrated that deletion of the endothelial ErbB4 receptor is associated with reduced glucose transport ability and is a key element involved in energy metabolism for brain function.
we show that the antifibrotic effect of neuregulin-1 (show NRG1 Proteins) is at least partially mediated through anti-inflammatory activity, linked to receptor tyrosine-protein kinase erbB-4 activation in macrophages
These results suggest that the neuropsin (show KLK8 Proteins)-NRG1 (show NRG1 Proteins) signaling system has a role in pathological processes underlying temporal lobe epilepsy by regulating the activity of parvalbumin (show PVALB Proteins)-expressing interneurons, and that neuropsin (show KLK8 Proteins) regulates E/I balance and gamma oscillations through NRG1 (show NRG1 Proteins)-ErbB4 signaling toward parvalbumin (show PVALB Proteins)-expressing interneurons.
findings reveal molecular, cellular, and circuit mechanisms of NRG1 (show NRG1 Proteins)/ErbB4 in regulating the initiation of critical period visual cortical plasticity.
To our knowledge, this is the first evidence that ErbB4 signaling in the MSNs is involved in the pathology of schizophrenia.
opposing signals generated by different ErbB (show EGFR Proteins) dimer combinations function in the same cardiac cushion mesenchymal cells for proper cardiac valve formation.
Study revealed that bed nucleus of the stria terminalis NRG1 (show NRG1 Proteins)-ErbB4 signaling is involved in regulating anxiety, and that blocking this pathway produced anxiety-like behavior.
Parallel microarray profiling identifies Erbb4 as a marker of cyst growth in autosomal dominant polycystic kidney disease and as a prognostic marker for disease progression.
a suppressor of miR (show MLXIP Proteins)-146a, suggesting an autocrine loop. Inhibition of ErbB4/EGFR (show EGFR Proteins) with erlotinib co-treatment of podocytes suppressed this signaling. Findings suggest a novel role for miR (show MLXIP Proteins)-146a in protecting against diabetic glomerulopathy and podocyte injury.
our study demonstrated and highlighted the strong prognostic value of HER4 in breast cancer carcinoma. The detection of the strong association of cytoplasmic HER4 with RFS might serve as an effective tool for investigating the multifunctionality of HER4 in predicting prognosis and its possible contribution to providing optimal treatment to patients with cancer.
In silico analysis suggested that rs1972820 located in the 3'UTR of ERBB4 gene affects the binding affinity of miR (show MLXIP Proteins)-3144-3p a potential oncomiRNA. Statistical analysis showed a significant association between SNP rs1972820 G allele and reduced breast cancer risk, odds ratio = 0.443 (95% CI: 0.196-0.998).
conclude from these results that this loss in Intron 1 of the ERBB4 gene is neither a de novo driver mutation nor a predisposing factor to GBM, despite the indications from CCLE
findings indicate that a SUMOylation-mediated mechanism regulates nuclear localization and function of the ICD (show GNPTAB Proteins) of ErbB4 receptor tyrosine kinase
Convergence between EGFR (show EGFR Proteins)/ErbB4 and canonical/noncanonical Wnt (show WNT2 Proteins) signaling determines cardiogenic fate in human pluripotent stem cells.
ERBB4 gene polymorphism is associated with the risk of congestive heart failure and prognosis in Chinese people.
High ERBB4 expression is associated with Merkel cell carcinoma
High ERBB4 expression is associated with colon cancer metastasis.
ERBB4 mutation is associated with Metaplastic Breast Cancer.
Results show higher expression levels of ErbB4 and KITENIN (show Vangl1 Proteins) in stage IV colorectal cancer tissues resulting in elevated phosphorylated level of ERBB2 (show ERBB2 Proteins).
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
, receptor tyrosine-protein kinase erbB-4
, v-erb-a erythroblastic leukemia viral oncogene homolog 4
, receptor tyrosine-protein kinase erbB-4-like
, receptor tyrosine kinase ErbB4
, receptor tyrosine-protein kinase ErbB-4
, ovarian receptor tyrosine kinase erbB4 precusor
, receptor tyrosine kinase
, avian erythroblastosis oncogene B 4
, proto-oncogene-like protein c-ErbB-4
, avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4
, tyrosine kinase-type cell surface receptor HER4