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anti-Human FGF21 Antibodies:
anti-Mouse (Murine) FGF21 Antibodies:
anti-Rat (Rattus) FGF21 Antibodies:
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Human Polyclonal FGF21 Primary Antibody for IF (p), IHC (p) - ABIN679478
Dong, Yu, Wu, Wang, Niu, Wang, Zou: Echinacoside Induces Apoptosis in Human SW480 Colorectal Cancer Cells by Induction of Oxidative DNA Damages. in International journal of molecular sciences 2015
FGF21 is a good predictor of acute-on-chronic liver failure and organ failure, is quite specific for cirrhosis, and seems independent of etiology and systemic inflammation.
FGF-21 could regulate the immune response indirectly by influencing the glucose uptake of activated monocytes cells.
FGF21 levels were reduced after energy-restricted treatments and severely increased after bariatric surgery, independently of the weight reduction magnitude, insulin (show INS Antibodies) sensitivity or ketosis; therefore, FGF21 appears to be a marker of severe nutritional stress
In HIV-infected individuals, FGF21 is significantly positively associated with liver fat. FGF21 decreases in association with reductions in liver fat, GGT (show GGT1 Antibodies), and FIB4, suggesting that FGF21 is upregulated in the context of steatosis and steatohepatitis and is reduced when these conditions improve
crystal structures of free and ligand-bound beta-klotho (show KLB Antibodies) extracellular regions that reveal the molecular mechanism that underlies the specificity of FGF21 towards beta-klotho (show KLB Antibodies) and demonstrate how the FGFR (show FGFR2 Antibodies) is activated in a klotho (show KL Antibodies)-dependent manner
In this review, we will summarize the current progress on the roles of FGF21 against metaflammation and metabolic tissue damage [Review]
This finding suggested FGF21 could be involved in the pathophysiology of diastolic heart failure.
FGF21 plasma levels correlate negatively with protein intake.
Serum FGF21 level was significantly correlated with left ventricular systolic function at baseline and higher levels resulted in greater levels of cardiac death.
In conclusion, our study, which focused on hepatic FGF21 and omentin (show ITLN1 Antibodies)-1 mRNA expression, confirmed marked expression of both molecules in the liver of morbidly obese patients with NAFLD (show TSC2 Antibodies).
The present study shows that expression of the FGF21 gene is strongly up-regulated during the transition period; the up-regulation of FGF21 might play an important role in the adaptation of liver metabolism during early lactation in dairy cows such as in other species.
RESULTS: The results showed that serum FGF-21 levels were significantly higher in both groups treated with a controlled-energy diet, while FGF-21 levels in both groups treated with moderate-energy diet were low.
liver-derived FGF21 regulates the use of lipid reserves during lactation via focal actions on liver and white adipose tissue.
Data, including data from studies using knockout mice, suggest that control of whole-body energy expenditure by Gcgr (show GCGR Antibodies) agonism requires intact Fxr (show NR1H4 Antibodies) signaling and Fgf21 secretion in liver. (Gcgr (show GCGR Antibodies) = glucagon receptor (show GCGR Antibodies) glucagon (show GCG Antibodies); Fxr (show NR1H4 Antibodies) = farnesoid X receptor (show xpr1 Antibodies); Fgf21 = fibroblast growth factor-21)
FGF-21 has anti-inflammatory effects in Type 2 diabetes mellitus
These data suggest that Fgf21 acts as one of intrathymic cytokines in the neonatal and juvenile thymus, involving thymocyte development in a beta (show SUCLA2 Antibodies)-Klotho (show KLB Antibodies)-independent manner.
During pregnancy, both systemic and cardiac-produced Fgf21 act on the heart, leading to the normal physiological cardiac changes that are associated with pregnancy.
our results demonstrated that FGF21 promotes cell cycle exit and enhances myogenic differentiation of C2C12 cells. This study provided new evidence that FGF21 promotes myogenic differentiation, which could be useful for better understanding the roles of FGF21 in myogenesis.
We will clarify the positive and negative signaling mechanisms which control the stress-related expression of FGF21 through the ISR pathway. Moreover, we will examine the role of FGF21 as an interorgan coordinator of survival functions in metabolic and stress disorders. We conclude that FGF21 can be viewed as a cell non-autonomous enhancer of longevity in mammals.
under nutrient-limiting conditions that stimulate ATF4 (show ATF4 Antibodies) activity, TRIB3 (show TRIB3 Antibodies) is implicated in the regulation of metabolic adaptation by restraining the transcription of Fgf21.
alcohol-induced FGF21 expression is a hepatic adaptive response to lipid dysregulation.
the adipose-derived FGF21-CCL11 axis triggers cold-induced beiging and thermogenesis by coupling sympathetic nervous system to activation of type 2 immunity in subcutaneous white adipose tissue.
These results uncover a negative feedback loop in which CREBH (show CREB3L3 Antibodies) regulates nonesterified fatty acid flux from adipose tissue to the liver via FGF21.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined.
fibroblast growth factor 21