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Human Polyclonal FGF21 Primary Antibody for IF (p), IHC (p) - ABIN679478
Dong, Yu, Wu, Wang, Niu, Wang, Zou: Echinacoside Induces Apoptosis in Human SW480 Colorectal Cancer Cells by Induction of Oxidative DNA Damages. in International journal of molecular sciences 2015
Human Polyclonal FGF21 Primary Antibody for ELISA, WB - ABIN314287
Inagaki, Dutchak, Zhao, Ding, Gautron, Parameswara, Li, Goetz, Mohammadi, Esser, Elmquist, Gerard, Burgess, Hammer, Mangelsdorf, Kliewer: Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. in Cell metabolism 2007
This finding suggested FGF21 could be involved in the pathophysiology of diastolic heart failure.
FGF21 plasma levels correlate negatively with protein intake.
Serum FGF21 level was significantly correlated with left ventricular systolic function at baseline and higher levels resulted in greater levels of cardiac death.
In conclusion, our study, which focused on hepatic FGF21 and omentin (show ITLN1 Antibodies)-1 mRNA expression, confirmed marked expression of both molecules in the liver of morbidly obese patients with NAFLD (show TSC2 Antibodies).
Serum FGF21 concentrations are decreased in anorexia nervosa and elevated in obesity. They are independently and positively related to BMI and insulin (show INS Antibodies) resistance
FGF-21 was positively associated with 10-year CHD (show CHDH Antibodies) risk
Serum FGF21 level was an independent predictor for new-onset metabolic syndrome in a population-based prospective study.
these findings elucidate the involvement of abnormal FGF21 expression in early APAP-induced liver impairment. Interestingly, FGF21 may be a promising biomarker of APAP-exposed livers.
Elevated circulating FGF21 level is an independent predictor of incident coronary heard disease in Chinese patients with type 2 diabetes mellitus.
Studied the role of fibroblast growth factor 21 (FGF21) in metabolic disorders; found FGF21 levels decreased in obesity, insulin (show INS Antibodies) resistance and metabolic syndrome.
The present study shows that expression of the FGF21 gene is strongly up-regulated during the transition period; the up-regulation of FGF21 might play an important role in the adaptation of liver metabolism during early lactation in dairy cows such as in other species.
RESULTS: The results showed that serum FGF-21 levels were significantly higher in both groups treated with a controlled-energy diet, while FGF-21 levels in both groups treated with moderate-energy diet were low.
liver-derived FGF21 regulates the use of lipid reserves during lactation via focal actions on liver and white adipose tissue.
our results demonstrated that FGF21 promotes cell cycle exit and enhances myogenic differentiation of C2C12 cells. This study provided new evidence that FGF21 promotes myogenic differentiation, which could be useful for better understanding the roles of FGF21 in myogenesis.
We will clarify the positive and negative signaling mechanisms which control the stress-related expression of FGF21 through the ISR pathway. Moreover, we will examine the role of FGF21 as an interorgan coordinator of survival functions in metabolic and stress disorders. We conclude that FGF21 can be viewed as a cell non-autonomous enhancer of longevity in mammals.
under nutrient-limiting conditions that stimulate ATF4 (show ATF4 Antibodies) activity, TRIB3 (show TRIB3 Antibodies) is implicated in the regulation of metabolic adaptation by restraining the transcription of Fgf21.
alcohol-induced FGF21 expression is a hepatic adaptive response to lipid dysregulation.
the adipose-derived FGF21-CCL11 axis triggers cold-induced beiging and thermogenesis by coupling sympathetic nervous system to activation of type 2 immunity in subcutaneous white adipose tissue.
These results uncover a negative feedback loop in which CREBH (show CREB3L3 Antibodies) regulates nonesterified fatty acid flux from adipose tissue to the liver via FGF21.
Chronic high-sucrose diet does not lead to obesity in mice. Data suggest that high-sucrose diet leads to up-regulation of Fgf21 expression in liver and brown adipose tissue plus high levels of Fgf21 in plasma which eventually lead to increased energy expenditure and, thus, does not cause obesity in this species.
plasma levels of Fgf21 reflect liver fat accumulation and dysregulation of metabolic pathways in the liver.
The ANT1 (show SLC25A4 Antibodies)-deficient muscle mitochondria produce excess reactive oxygen species (ROS (show ROS1 Antibodies)) and are partially uncoupled. Hence, the muscle respiration under nonphosphorylating conditions is increased. Muscle transcriptome analysis revealed the induction of mitochondrial biogenesis, down-regulation of diabetes-related genes, and increased expression of the genes encoding the myokines FGF21 and GDF15 (show GDF15 Antibodies).
atheroprotective effect of brown adipose transplantation is BAT-specific and independent of lipid-lowering effect, accompanied by adrenergic receptor-mediated activation of the FGF-21-adiponectin axis.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined.
fibroblast growth factor 21