|Antigen||Fibroblast Growth Factor 4 (FGF4) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This FGF4 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
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Product Details anti-FGF4 AntibodyTarget Details FGF4 Application Details Handling Images
|Specificity||This antibody reacts to FGF4.|
|Purification||Affinity chromatography purified via peptide column|
|Immunogen||FGF4 antibody was raised against a 18 amino acid peptide near the carboxy terminus of the human FGF4.|
Target Details FGF4Product Details anti-FGF4 Antibody Application Details Handling Images back to top
|Alternative Name||FGF4 (FGF4 Antibody Abstract)|
|Background||Fibroblast growth factor 4 (FGF4) is a member of the fibroblast growth factor (FGF) family that possess broad mitogenic and cell survival activities and play key roles in growth and survival of stem cells during embryogenesis, tissue regeneration, and carcinogenesis. FGF4 was identified by its strong oncogenic transforming activity and is a potent angiogenic factor, expressed in several highly vascularized tumors and also in adult mouse testis, intestine, and brain. Studies on the mouse homolog suggests a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. Furthermore, FGF4 regulates neural progenitor cell proliferation and neuronal differentiation. Recent studies show a growth-promoting role for FGF4 in human embryonic stem cells and a putative feedback inhibition mechanism by a novel FGF4 splice isoform that may serve to promote differentiation at a later stages of development.Synonyms: Fibroblast growth factor 4, HST, HST-1, HSTF1, Heparin secretory-transforming protein, Heparin-binding growth factor 4, KS3, Transforming protein KS3|
|Pathways||RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance|
Application DetailsProduct Details anti-FGF4 Antibody Target Details FGF4 Handling Images back to top
ELISA. Western Blot: 0.5 - 1 μg/mLImmunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-FGF4 Antibody Target Details FGF4 Application Details Images back to top
|Buffer||PBS containing 0.02 % sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store the antibody undiluted at 2-8 °C.|