Browse our anti-FGF8 (FGF8) Antibodies

Mouse (Murine) Fibroblast Growth Factor 8 (Androgen-Induced) (FGF8) interaction partners

1. We demonstrate with genetic evidence that the Wnt5a (show WNT5A Antibodies) gradient acts as a global cue that is instructive in establishing planar cell polarity (PCP (show BMP1 Antibodies)) in the limb mesenchyme, and that Wnt5a (show WNT5A Antibodies) also plays a permissive role to allow Fgf4 (show FGF4 Antibodies) and Fgf8 signaling to orient PCP (show BMP1 Antibodies).

2. THe Fgf8-Cre reporter expression in isthmic structures in mice include 'signature' isthmic structures in mice include the trochlear nucleus, the dorsal raphe nucleus, the microcellular tegmental nuclei, the pedunculotegmental nucleus, the vermis of the cerebellum, rostral parts of the parabrachial complex and locus coeruleus, and the caudal (show CAD Antibodies) parts of the substantia nigra and VTA.

3. Results indicate that perinatal fibroblast growth factor 8 (FGF8) signaling is important for the timing of the onset of anterior-dorsal glial fibrillary acidic protein (show GFAP Antibodies) expression in midline glial cells suggesting that FGF8 function regulates midline GFAP (show GFAP Antibodies)-IR glial cell development, which when disrupted by Fgf8 deficiency prevents the formation of the corpus callosum.

4. The FBLN1 (show FBLN1 Antibodies)/FGF8 interaction may also be involved in the survival of neural crest cell population during development.

5. These results indicate that the modulatory effects of SHH (show SHH Antibodies) on BALB/c mouse metanephric explant cultures may involve the regulation of Fgf8 expression but not Fgf10 (show FGF10 Antibodies) expression, which provides evidence for the functional role of Fgf proteins in renal morphogenesis.

6. FGF-8 was revealed to suppress BMP-induced osteoblast differentiation through the ERK (show EPHB2 Antibodies) pathway and the effects were enhanced by TNF-alpha (show TNF Antibodies).

7. Fgf8 expression is required for the continued postnatal development/maturation of the Vasopressin (show AVP Antibodies) and CRH (show CRH Antibodies) neurons in the Paraventricular nucleus.

8. Deregulated FGF8 and Otx2 (show OTX2 Antibodies)/Gbx2 (show GBX2 Antibodies) gene expression underlies cerebellar vermis hypoplasia in mouse model of CHARGE syndrome.

9. Cre fate mapping in Fgf8 mutant embryos revealed novel functions of this gene in rostral patterning center progenitor development. Disruption resulted in aberrant progenitor number and distribution in the rostral telencephalon.

10. Tfap2a (show TFAP2A Antibodies)-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage

Human Fibroblast Growth Factor 8 (Androgen-Induced) (FGF8) interaction partners

1. we also found that FGF8 increased the expression of YAP1 (show YAP1 Antibodies) and knockdown of YAP1 (show YAP1 Antibodies) eliminated the upregulation of EGFR (show EGFR Antibodies) and the resistance to EGFR (show EGFR Antibodies) inhibition induced by FGF8. Our study provides evidence that FGF8 plays an important role in the resistance to EGFR (show EGFR Antibodies) inhibition of human hepatocellular carcinoma cells

2. Genetic testing identified a de novo, heterozygous mutation in fibroblast growth factor receptor 1 (FGFR1 (show FGFR1 Antibodies) p.L630P). L630 resides on the ATP binding cleft of the FGFR1 (show FGFR1 Antibodies) tyrosine kinase (show TXK Antibodies) domain, and L630P is predicted to cause a complete loss of receptor function. Cell-based assays confirmed that L630P abolishes FGF8 signaling activity

3. Bonferroni adjusted p-value: 0.04). No statistically significant associations were identified in the other ethnic groups. In conclusion, variant/s in FGF2 and FGF8 may predispose diabetics with CKD to LEA.

4. in one holoprosencephaly (HPE) family, a deleterious FGFR1 (show FGFR1 Antibodies) allele was transmitted from one parent and a loss-of-function allele in FGF8 from the other parent to both affected daughters. This family is one of the clearest examples to date of gene:gene synergistic interactions causing HPE in humans.

5. The FBLN1 (show FBLN1 Antibodies)/FGF8 interaction may also be involved in the survival of neural crest cell population during development.

6. Fgf8 activates Ras-ERK (show EPHB2 Antibodies) pathway to specify hindbrain. Downstream of ERK (show EPHB2 Antibodies), Pea3 (show ETV4 Antibodies) specifies isthmus (rhombomere 0, r0), and Irx2 (show IRX2 Antibodies) may specify r1, where the cerebellum is formed.

7. Regulation of neurogenesis by Fgf8a requires Cdc42 (show CDC42 Antibodies) signaling and a novel Cdc42 effector (show FNBP1L Antibodies) protein

8. Our results link FGF8, c-Abl (show ABL1 Antibodies) and p300 (show EP300 Antibodies) in a regulatory pathway that controls DeltaNp63alpha protein stability and transcriptional activity.

9. Data indicate that overexpression of fibroblast growth factor 8 (FGF8) correlates with lymph node metastasis and poor prognosis in colorectal cancer (CRC (show CALR Antibodies)).

10. FGF8 mutations (p.Gly29_Arg34dup and p.Pro26Leu) contribute to the formation of the VATER/VACTERL association.

Cow (Bovine) Fibroblast Growth Factor 8 (Androgen-Induced) (FGF8) interaction partners

1. FGF8 and FGF18 (show FGF18 Antibodies) signal through divergent pathways in ovarian granulosa cells, despite reportedly similar receptor activation patterns.

2. These results suggest that polymorphisms discovered in DECR1 (show DECR1 Antibodies), CBFA2T1 (show RUNX1T1 Antibodies), and FGF8 may play a role in the lipid metabolism pathway affecting carcass quality traits in beef cattle.