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Submit your validation data for this product and get a full refund. I want to validate this productRelevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
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3.2597933 | ABIN2788320 | WB | Rabbit | Middle Region | Log in to see | Polyclonal | 0 | |||
1 | ABIN611352 | WB | Rabbit | AA 292-341 | Log in to see | Polyclonal | 2 | |||
1 | ABIN611351 | WB | Rabbit | AA 508-557 | Log in to see | Polyclonal | 0 |
General |
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Antigen | Fibroblast Growth Factor Receptor 2 (FGFR2) Antibodies |
Epitope | C-Term Alternatives |
Reactivity | Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus), Sheep (Ovine), Zebrafish (Danio rerio) Alternatives |
Host | Rabbit Alternatives |
Clonality | |
Conjugate | This FGFR2 antibody is un-conjugated Alternatives |
Application |
Western Blotting (WB)
Alternatives
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Supplier | Log in to see |
Product Details anti-FGFR2 AntibodyTarget Details FGFR2 Application Details Handling Images |
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Blocking Peptide | Blocking peptide for this product available: ABIN976842 |
Sequence | KPKEAVTVAV KMLKDDATEK DLSDLVSEME MMKMIGKHKN IINLLGACTQ |
Predicted Reactivity | Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 93%, Zebrafish: 100% |
Characteristics | This is a rabbit polyclonal antibody against FGFR2. It was validated on Western Blot. |
Purification | Affinity Purified |
Immunogen | The immunogen is a synthetic peptide directed towards the C terminal region of human FGFR2 |
Target Details FGFR2Product Details anti-FGFR2 Antibody Application Details Handling Images back to top |
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Antigen | |
Alternative Name | FGFR2 (FGFR2 Antibody Abstract) |
Background |
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. Alias Symbols: BEK, BFR-1, CD332, CEK3, CFD1, ECT1, FLJ98662, JWS, K-SAM, KGFR, TK14, TK25 Protein Interaction Partner: PPM1A, APP, HGS, UBC, LYN, FYN, CBL, NEDD4, FRS2, STAT5B, STAT5A, PGR, STAT3, ITGA5, PAK4, FGF23, FGF18, FGF17, EPHA4, FGF10, PTK2B, FGF9, FGF8, PLCG1, FGF5, FGF4, FGF3, FGF7, FGF6, FGF1, CACNA1D, PIK3R1, FGFR2, Protein Size: 705 |
Molecular Weight | 78 kDa |
Gene ID | 2263 |
NCBI Accession | NM_022970, NP_075259 |
UniProt | P21802 |
Pathways | RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Growth Factor Binding |
Application DetailsProduct Details anti-FGFR2 Antibody Target Details FGFR2 Handling Images back to top |
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Application Notes | Optimal working dilutions should be determined experimentally by the investigator. |
Comment |
Antigen size: 705 AA |
Restrictions | For Research Use only |
HandlingProduct Details anti-FGFR2 Antibody Target Details FGFR2 Application Details Images back to top |
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Format | Liquid |
Concentration | Lot specific |
Buffer | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose. |
Preservative | Sodium azide |
Precaution of Use | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handling Advice | Avoid repeated freeze-thaw cycles. |
Storage | -20 °C |
Storage Comment | For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. |
ImagesProduct Details anti-FGFR2 Antibody Target Details FGFR2 Application Details Handling back to top |
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Supplier Images |