anti-Human FGFR2 antibody for Enzyme Immunoassay

Recommended FGFR2 Antibody (supplied by: Log in to see )

Antigen
Fibroblast Growth Factor Receptor 2 (FGFR2) Antibodies
  • FGFR2
  • FGFR2IIIb
  • bek
  • bfr-1
  • cd332
  • cek3
  • cfd1
  • ect1
  • fgfr-2
  • jws
  • k-sam
  • kgfr
  • tk14
  • tk25
  • xfgfr2
  • DKFZp469H1521
  • BBDS
  • BEK
  • BFR-1
  • CD332
  • CEK3
  • CFD1
  • ECT1
  • JWS
  • K-SAM
  • KGFR
  • TK14
  • TK25
  • AU043015
  • AW556123
  • Bek
  • Fgfr-2
  • Fgfr-7
  • Fgfr7
  • KGFRTr
  • svs
  • FGF-R
  • fgfr72IIIb
  • FGFR
  • fc56c05
  • wu:fc56c05
  • fibroblast growth factor receptor 2
  • fibroblast growth factor receptor 2 L homeolog
  • FGFR2
  • LOC100084641
  • fgfr2
  • Fgfr2
  • fgfr2.L
Epitope
N-Term
25
24
21
18
14
10
8
8
7
6
6
6
5
5
5
5
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
305
94
62
13
6
6
5
4
4
4
4
3
3
3
1
1
Host
Rabbit
203
88
16
15
Clonality
Polyclonal
Conjugate
This FGFR2 antibody is un-conjugated
14
14
11
10
10
9
6
6
5
5
5
5
5
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
227
129
120
116
73
66
16
12
11
7
4
4
4
1
1
1
1
Supplier
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Catalog No. ABIN359856
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN359854 EIA IHC (p) WB Rabbit Ig Fraction N-Term Log in to see Polyclonal 5
1 ABIN359855 EIA IHC (p) WB Rabbit Ig Fraction C-Term Log in to see Polyclonal 5
1 ABIN359857 EIA WB Rabbit Ig Fraction Log in to see Polyclonal 4
1 ABIN5553701 EIA WB Goat Internal Region Log in to see Polyclonal 0
1 ABIN5611560 EIA IHC (p) WB Rabbit IgG Internal Region Log in to see Polyclonal 0
1 ABIN781863 EIA IHC (p) WB Mouse IgG2b Log in to see 1G3 0
1 ABIN2717927 EIA Rabbit IgG Log in to see Polyclonal 0

General

Antigen Fibroblast Growth Factor Receptor 2 (FGFR2) Antibodies
Epitope N-Term
(25), (24), (21), (18), (14), (10), (8), (8), (7), (6), (6), (6), (5), (5), (5), (5), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(305), (94), (62), (13), (6), (6), (5), (4), (4), (4), (4), (3), (3), (3), (1), (1)
Host Rabbit
(203), (88), (16), (15)
Clonality
Polyclonal
Conjugate This FGFR2 antibody is un-conjugated
(14), (14), (11), (10), (10), (9), (6), (6), (5), (5), (5), (5), (5), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Western Blotting (WB)
(227), (129), (120), (116), (73), (66), (16), (12), (11), (7), (4), (4), (4), (1), (1), (1), (1)
Pubmed 5 references available
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Product Details anti-FGFR2 Antibody

Target Details FGFR2 Application Details Handling References for anti-FGFR2 antibody (ABIN359856) Images
Specificity This antiobdy reacts to FGFR2.
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human FGFR2.
Isotype Ig Fraction

Target Details FGFR2

Product Details anti-FGFR2 Antibody Application Details Handling References for anti-FGFR2 antibody (ABIN359856) Images back to top
Antigen
Alternative Name CD332 / FGFR-2 (FGFR2 Antibody Abstract)
Background FGFR2 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in the gene for FGFR2 are associated with many craniosynostotic syndromes and bone malformations. The genomic organization of the gene encompasses 20 exons. Alternative splicing in multiple exons, including those encoding the Ig-like domains, the transmembrane region and the carboxyl terminus, results in varied isoforms which differ in structure and specificity. Isoform 1 has equal affinity for aFGF and bFGF but does not bind KGF.Synonyms: BEK, FGFR2, Fibroblast growth factor receptor 2, KGFR, KSAM, Keratinocyte growth factor receptor 2
Gene ID 2263, 9606
UniProt P21802
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Growth Factor Binding

Application Details

Product Details anti-FGFR2 Antibody Target Details FGFR2 Handling References for anti-FGFR2 antibody (ABIN359856) Images back to top
Application Notes ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-FGFR2 Antibody Target Details FGFR2 Application Details References for anti-FGFR2 antibody (ABIN359856) Images back to top
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

References for anti-FGFR2 antibody (ABIN359856)

Product Details anti-FGFR2 Antibody Target Details FGFR2 Application Details Handling Images back to top
Background publications

Freeman, Gangula, Welm, Ozen, Foster, Rosen, Ittmann, Greenberg, Spencer et al.: "Conditional activation of fibroblast growth factor receptor (FGFR) 1, but not FGFR2, in prostate cancer cells leads to increased osteopontin induction, extracellular signal-regulated kinase ..." in: Cancer research, Vol. 63, Issue 19, pp. 6237-43, 2003

Goriely, McVean, Röjmyr, Ingemarsson, Wilkie: "Evidence for selective advantage of pathogenic FGFR2 mutations in the male germ line." in: Science (New York, N.Y.), Vol. 301, Issue 5633, pp. 643-6, 2003

Fomenkov, Huang, Topaloglu, Brechman, Osada, Fomenkova, Yuriditsky, Trink, Sidransky, Ratovitski: "P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome." in: The Journal of biological chemistry, Vol. 278, Issue 26, pp. 23906-14, 2003

Katoh, Katoh: "Recombination cluster around FGFR2-WDR11-HTPAPL locus on human chromosome 10q26." in: International journal of molecular medicine, Vol. 11, Issue 5, pp. 579-83, 2003

Katoh, Katoh: "FGFR2 and WDR11 are neighboring oncogene and tumor suppressor gene on human chromosome 10q26." in: International journal of oncology, Vol. 22, Issue 5, pp. 1155-9, 2003

Images

Product Details anti-FGFR2 Antibody Target Details FGFR2 Application Details Handling References for anti-FGFR2 antibody (ABIN359856) back to top
Supplier Images
Western Blotting (WB) image for anti-Fibroblast Growth Factor Receptor 2 (FGFR2) (N-Term) antibody (ABIN359856) Western blot analysis of anti-FGFR2 Antibody (N-term) in Hela cell line lysates (35ug...