anti-Mouse (Murine) FGFR4 antibody for Immunohistochemistry

Recommended FGFR4 Antibody (supplied by: Log in to see )

Antigen
Fibroblast Growth Factor Receptor 4 (FGFR4) Antibodies
  • FGFR4
  • XFGFR-4
  • XFGFR-4a
  • cd334
  • fgfr-4
  • jtk2
  • tkf
  • xfgfr4
  • CD334
  • JTK2
  • TKF
  • Fgfr-4
  • etID309818.21
  • wu:fc13h10
  • zgc:111935
  • fgfr-4c
  • fgfr4
  • fibroblast growth factor receptor 4
  • fibroblast growth factor receptor 4 S homeolog
  • FGFR4
  • fgfr4
  • Fgfr4
  • fgfr4.S
Epitope
pTyr642
19
16
14
11
9
6
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
195
62
53
3
3
Host
Rabbit
133
67
10
Clonality
Polyclonal
Conjugate
This FGFR4 antibody is un-conjugated
9
8
7
5
4
3
2
2
2
2
2
1
1
1
1
1
1
1
1
Application
ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
162
103
58
34
32
26
13
10
8
7
5
3
2
1
1
1
Supplier
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Catalog No. ABIN6269937
$ 450.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN4311566 IHC IHC (p) WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN5013553 ICC IHC WB Rabbit IgG AA 165-366 Log in to see Polyclonal 0
1 ABIN5697674 ELISA IHC WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN2750027 ELISA IHC IP WB FITC Rabbit IgG AA 520-570 Log in to see Polyclonal 0
1 ABIN2750026 ELISA IHC IP WB Rabbit IgG AA 520-570 Log in to see Polyclonal 0
1 ABIN2929297 IF/ICC IHC IP WB Rabbit AA 165-366 Log in to see Polyclonal 0
1 ABIN1086147 IHC ELISA WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN2929296 ELISA IHC WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN5865589 ELISA IHC WB Rabbit IgG Log in to see Polyclonal 0
1 ABIN5578121 ELISA IHC WB Rabbit Log in to see Polyclonal 0
1 ABIN5557770 ELISA IHC IP WB Biotin Rabbit Log in to see Polyclonal 0

General

Antigen Fibroblast Growth Factor Receptor 4 (FGFR4) Antibodies
Epitope pTyr642
(19), (16), (14), (11), (9), (6), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(195), (62), (53), (3), (3)
Host Rabbit
(133), (67), (10)
Clonality
Polyclonal
Conjugate This FGFR4 antibody is un-conjugated
(9), (8), (7), (5), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
(162), (103), (58), (34), (32), (26), (13), (10), (8), (7), (5), (3), (2), (1), (1), (1)
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Product Details anti-FGFR4 Antibody

Target Details FGFR4 Application Details Handling Images
Specificity Phospho-FGFR4 (Tyr642) Antibody detects endogenous levels of FGFR4 only when phosphorylated at Tyr642
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Purification The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Immunogen A synthesized peptide derived from human FGFR4 around the phosphorylation site of Tyr642
Isotype IgG
Plasmids, Primers & others

Target Details FGFR4

Product Details anti-FGFR4 Antibody Application Details Handling Images back to top
Antigen
Alternative Name FGFR4 (FGFR4 Antibody Abstract)
Background

Description: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation, MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

Gene: FGFR4

Molecular Weight 87.9kDa
Gene ID 2264
UniProt P22455
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding

Application Details

Product Details anti-FGFR4 Antibody Target Details FGFR4 Handling Images back to top
Application Notes WB 1:500-1:2000, IHC 1:50-1:200
Restrictions For Research Use only

Handling

Product Details anti-FGFR4 Antibody Target Details FGFR4 Application Details Images back to top
Format Liquid
Concentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20 °C.Stable for 12 months from date of receipt
Expiry Date 12 months

Images

Product Details anti-FGFR4 Antibody Target Details FGFR4 Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Fibroblast Growth Factor Receptor 4 (FGFR4) (pTyr642) antibody (ABIN6269937) ABIN6269938 at 1/100 staining rat lung tissue sections by IHC-P. The tissue was forma...