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Gas6 stimulates angiogenesis of human retinal endothelial cells and of zebrafish embryos via ERK1/2 signaling.
Taken together, in our study Gas6 fails to aggravate calcification against the previous assumption.
The present study provides evidence that the vitamin K-dependent protein growth arrest specific 6 (Gas6) promotes such repair in in vitro cultures of mouse optic nerve and cerebellum.
Gas6 specifically promotes the recruitment of inflammatory CCR2 (show CCR2 Proteins)(hi)CX3CR1 (show CX3CR1 Proteins)(lo) monocytes through the regulation of both CCR2 (show CCR2 Proteins) and CCL2 (show CCL2 Proteins) during deep venous thrombosis.
Gas6/Axl (show AXL Proteins) and Akt (show AKT1 Proteins)/FoxO1a (show FOXO1 Proteins) were involved in protective effects of testosterone on VSMCs senescence and collagen synthesis.
Gas6-mediated uptake is not a means to clear the bulk of circulating membrane-derived microparticles (PMPs) but may serve to locally phagocytose PMPs generated at sites of platelet activation and as a way to effect endothelial responses.
Gas6-FoxO-1 (show FOXO1 Proteins) signaling axis plays an important role in VCAM-1 (show VCAM1 Proteins) expression in the context of venous thromboembolism by promoting bone marrow mononuclear cell-endothelial cell adhesion.
Gas6 and Axl (show AXL Proteins) serum levels increase in parallel to chronic liver disease progression inactivation.
Gas6, through upregulation of Ptges (show PTGES Proteins)/PGE2, contributes to cancer-induced venous thrombosis.
Gas6-induced Axl (show AXL Proteins) signaling is a critical driver of pancreatic cancer progression.
Gas6/Axl (show AXL Proteins) signaling is essential for delaying the cellular senescence process regulated by the PI3K/Akt (show AKT1 Proteins)/FoxO (show FOXO3 Proteins) signaling pathway.
Suppression of AXL by shRNA and inhibitor prolonged survival of chronic myelogenous leukemia (CML) mice and reduced the growth of leukemia stem cells ( LSCs) in mice. Gas6/AXL ligation stabilizes beta-catenin in an AKT-dependent fashion in human CML CD34(+) cells. Our findings improve the understanding of LSC regulation and validate Gas6/AXL as a pair of therapeutic targets to eliminate CML LSCs
AXL (show AXL Proteins)+ and GAS6+ expression is relevant to a poor prognosis in resected lung adenocarcinoma (AD)patients at stage I. AXL (show AXL Proteins)/GAS6 might serve as crucial predictive and prognostic biomarkers and targets to identify individuals at high risk of post-operative death.
Taken together, our data indicate that elevated plasma Gas6 levels is associated with the severity of disease during HTNV infection in humans, suggesting that Gas6 may play an important role by binding with Tyro3 (show TYRO3 Proteins) on monocytes.
Study detected an inverse correlation between CSF (show CSF2 Proteins) Gas6 levels at Alzheimer's disease (AD) diagnosis and both disease duration and decrease in the MMSE score two years later. Conversely,no correlation was found between CSF (show CSF2 Proteins) Gas6 and both AD biomarkers and years of formal schooling. Results suggest that upregulation of CSF (show CSF2 Proteins) Gas6 may be part of a defensive response aimed at counteracting AD progression.
Upon chemotherapy macrophages increase Gas6 synthesis, which significantly attenuates the cytotoxic effect of 5-FU chemotherapy on colorectal cancer cells.
These results show that TYRO3 (show TYRO3 Proteins), AXL (show AXL Proteins) and GAS6 are expressed at higher levels in LMS and expression of its ligands correlates to a worse PFS in LMS patients.
these data suggest that endogenous GAS6 and Mer (show MERTK Proteins) receptor signaling contribute to the establishment of prostate cancer stem cells in the bone marrow microenvironment
The GAS6-AXL (show AXL Proteins) signaling network is a mesenchymal (Mes (show ME1 Proteins)) molecular subtype-specific therapeutic target for ovarian cancer
The expression of AXL was positively associated with GAS6 expression (P < 0.001), and tumor differentiation (P = 0.014) in advanced NSCLC with metastases. AXL expression displayed no association with gender, age, smoking history, pathology, T stage, N stage, CEA, and LDH.
These results demonstrate that Gas6/Axl (show AXL Proteins) axis confers aggressiveness in breast cancer.
The results imply that the GAS6 gene can be considered a potential candidate for meat quality trait selection and fat deposition in pigs.
This gene product is a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation, and may play a role in thrombosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
growth arrest specific 6
, growth arrest-specific protein 6
, growth arrest-specific 6
, growth arrest-specific protein 6-like
, AXL receptor tyrosine kinase ligand
, GAS 6
, growth-potentiating factor
, AXL stimulatory factor