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Our findings position Grb2 as a key adaptor that integrates various cytokines response in cycling Hematopoietic Stem and Progenitor Cell .
Themis1 acts as a positive regulator of TCR signaling during thymocyte development by promoting Vav1 (show VAV1 Proteins) activity and Grb2 stability
Myogenic differentiation depends on the expression regulation patterns of Grb2 and N-WASP.
Two Dtna (show DTNA Proteins) interactors, alpha-catulin (show CTNNAL1 Proteins) (phosphorylation independent) and Grb2 (phosphorylation dependent) are localized to neuromuscular junctions in vivo, and are required for proper organization of neurotransmitter receptors on myotubes.
Grb2-deficient T cells show defects in T cell development, increased Th1 (show HAND1 Proteins) and Th17 cell differentiation capacities, and impaired proliferation after activation by dendritic cells, which likely reduce the clinical symptoms of EAE.
provide evidence that CD28 (show CD28 Proteins) and the TCR complex regulate NF-kappaB (show NFKB1 Proteins) via different signaling modules of GRB-2/VAV1 (show VAV1 Proteins) and LAT (show LAT Proteins)/ADAP (show APP Proteins) pathways respectively.
GRB2 physically links cyt (show CYGB Proteins)-PTPe (show PTPRE Proteins) with Src (show SRC Proteins) and enables cyt (show CYGB Proteins)-PTPe (show PTPRE Proteins) to activate Src (show SRC Proteins) downstream of activated integrins in osteoclast-like cells.
SUMOylation of Grb2 enhances the ERK (show EPHB2 Proteins) activity by increasing its binding with Sos1 (show SOS1 Proteins).
Data indicate that growth factor receptor (show RYK Proteins) protein binding protein 2 (Grb2) is upregulated and regulated by Forkhead Box D3 (Foxd3 (show FOXD3 Proteins)), and pregulated Grb2 interacts with huntingtin (Htt (show HTT Proteins)).
Grb2 contributes to immunoreceptor tyrosine-based activation motif signaling in platelets during hemostasis and thrombosis.
Data indicate GRB2 as a direct target of miR (show MLXIP Proteins)-329 in pancreatic cancer cells, and expression of GRB2 was inversely correlated with miR (show MLXIP Proteins)-329 expression in pancreatic cancer patients.
EGFR (show EGFR Proteins) colocalization with GRB2 as assessed by PLA is not correlated with EGFR (show EGFR Proteins) expression levels or mutation status, defining a patient group that may show EGFR (show EGFR Proteins) pathway activation, as illustrated by its prognostic value.
Low GRB2 expression is associated with Breast Cancer.
Rab13 (show RAB13 Proteins) activated the downstream AMPK (show PRKAA1 Proteins) and blocked mTOR (show FRAP1 Proteins) signaling by its functional interaction with Grb2 to regulate autophagy in human vascular endothelial cells.
ACTB (show ACTB Proteins), CDKN1B (show CDKN1B Proteins), GAPDH (show GAPDH Proteins), GRB2, RHOA (show RHOA Proteins) and SDCBP (show SDCBP Proteins) are potent reference genes in neuroendocrine tumors of the lung.
We show that the decrease in PI(4,5)P2 level under non-stimulated conditions inhibits PTEN activity leading to the aberrant activation of the oncoprotein Akt (show AKT1 Proteins). As well as defining a novel mechanism of Akt (show AKT1 Proteins) phosphorylation with important therapeutic consequences, we also demonstrate that differential expression levels of FGFR2 (show FGFR2 Proteins), Plc11 and Grb2 correlate with patient survival
Following phosphorylation of the tyrosine, the proteins growth factor receptor-bound protein 2 (Grb2), Grb2-related adaptor downstream of Shc (show SHC1 Proteins) (Gads (show GRAP2 Proteins)), and p85 subunit of phosphoinositide 3-kinase may bind to pYMNM (where pY is phosphotyrosine) via their Src (show SRC Proteins) homology 2 (SH2) domains, leading to downstream signaling to distinct immune pathways. These three adaptor proteins bind to the same site on CD28 (show CD28 Proteins) with variable affinity
investigated the target and mechanism of miR-411-5p in breast cancer using mimic and inhibitor, and demonstrated the involvement of GRB2 and Ras activation
The study presents EPR (show EREG Proteins) spectroscopic analysis of the binding of the wild-type and mutant Grb2 SH2 domains to the CSpYVNVQC peptide variant. These data confirm that the binding specificity of SH2 domains, even that of Grb2, results from multiple factors and does not depend merely on the nature of one particular residue.
TGF-beta2 (show TGFB2 Proteins) induces Grb2 to recruit PI3-K (show PIK3CA Proteins) to TGF-RII that activates JNK (show MAPK8 Proteins)/AP-1 (show FOSB Proteins)-signaling and augments invasiveness of Theileria-transformed macrophages.
in VSMCs exposed to hyperglycemia, IGF-I (show IGF1 Proteins) stimulation of Shc (show SHC1 Proteins) facilitates the transfer of Grb2 to p85 (show ARHGEF7 Proteins) resulting in enhanced PI3K activation and AKT (show AKT1 Proteins) phosphorylation leading to enhanced cell proliferation and migration
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
growth factor receptor-bound protein 2
, Growth factor receptor-bound protein 2
, SH2/SH3 adapter GRB2
, adapter protein GRB2
, protein Ash
, abundant SRC homology
, epidermal growth factor receptor-binding protein GRB2
, growth factor receptor-bound protein 3
, growth factor receptor bound protein 2