anti-Human HER2 antibody for Immunohistochemistry (Formalin-fixed Sections)

Recommended HER2 Antibody (supplied by: Log in to see )

Antigen
V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Antibodies
  • CD340
  • HER-2
  • HER-2/neu
  • HER2
  • MLN 19
  • NEU
  • NGL
  • TKR1
  • Erbb-2
  • Neu
  • c-erbB2
  • c-neu
  • mKIAA3023
  • wu:fv70f10
  • zgc:63601
  • erb2
  • erb-b2 receptor tyrosine kinase 2
  • ERBB2
  • Erbb2
  • erbb2
Reactivity
Human
1294
405
313
31
22
10
6
6
6
4
4
3
3
3
3
3
2
2
2
2
1
1
1
Host
Mouse
773
583
23
16
10
3
3
Clonality
Monoclonal
Conjugate
This HER2 antibody is un-conjugated
57
44
44
42
41
27
18
18
11
11
11
10
10
9
8
8
8
8
8
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
2
2
1
Application
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunoprecipitation (IP)
672
453
411
411
352
192
192
102
99
98
96
46
24
21
18
11
6
3
3
3
2
1
1
1
1
1
1
1
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

Submit your validation data for this product and get a full refund. I want to validate this product

Learn more

Catalog No. ABIN2688859
Contact our Customer Service for availability and price in your country.
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN6183876 FACS IF IHC (f) CF405M Mouse IgG1, kappa Log in to see ERB2-776 0
1 ABIN6183884 FACS IF IHC (f) CF®555 Mouse IgG1, kappa Log in to see ERB2-776 0
1 ABIN6183890 FACS IF IHC (f) CF®770 Mouse IgG1, kappa Log in to see ERB2-776 0
1 ABIN6183892 FACS IF IHC (f) CF®680 Mouse IgG1, kappa Log in to see ERB2-776 0
1 ABIN6183898 FACS IF IHC (f) CF®594 Mouse IgG1, kappa Log in to see ERB2-776 0
1 ABIN6183896 FACS IF IHC (f) CF®488A Mouse IgG1, kappa Log in to see ERB2-776 0
1 ABIN6184030 FACS IF IHC (f) CF®640R Mouse IgG1, kappa Log in to see HRB2-451 0
1 ABIN6184036 FACS IF IHC (f) CF®555 Mouse IgG1, kappa Log in to see HRB2-451 0
1 ABIN6184038 FACS IF IHC (f) CF®660R Mouse IgG1, kappa Log in to see HRB2-451 0
1 ABIN6184044 FACS IF IHC (f) CF®680 Mouse IgG1, kappa Log in to see HRB2-451 0
1 ABIN6184050 FACS IF IHC (f) CF®594 Mouse IgG1, kappa Log in to see HRB2-451 0
1 ABIN6183882 FACS IF IHC (f) CF®647 Mouse IgG1, kappa Log in to see ERB2-776 0
1 ABIN6183886 FACS IF IHC (f) CF®660R Mouse IgG1, kappa Log in to see ERB2-776 0
1 ABIN6183894 FACS IF IHC (f) CF®680R Mouse IgG1, kappa Log in to see ERB2-776 0
1 ABIN6183874 FACS IF IHC (f) CF®405S Mouse IgG1, kappa Log in to see ERB2-776 0
1 ABIN6183878 FACS IF IHC (f) CF®640R Mouse IgG1, kappa Log in to see ERB2-776 0
1 ABIN6183880 FACS IF IHC (f) CF®543 Mouse IgG1, kappa Log in to see ERB2-776 0
1 ABIN6183888 FACS IF IHC (f) CF®568 Mouse IgG1, kappa Log in to see ERB2-776 0
1 ABIN6184026 FACS IF IHC (f) CF®405S Mouse IgG1, kappa Log in to see HRB2-451 0
1 ABIN6184032 FACS IF IHC (f) CF®543 Mouse IgG1, kappa Log in to see HRB2-451 0

General

Antigen V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Antibodies
Reactivity Human
(1294), (405), (313), (31), (22), (10), (6), (6), (6), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1)
Host Mouse
(773), (583), (23), (16), (10), (3), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate This HER2 antibody is un-conjugated
(57), (44), (44), (42), (41), (27), (18), (18), (11), (11), (11), (10), (10), (9), (8), (8), (8), (8), (8), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (2), (2), (1)
Application Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunoprecipitation (IP)
(672), (453), (411), (411), (352), (192), (192), (102), (99), (98), (96), (46), (24), (21), (18), (11), (6), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 7 references available
Supplier Log in to see

Product Details anti-HER2 Antibody

Target Details HER2 Application Details Handling References for anti-HER2 antibody (ABIN2688859) Images
Brand BD Pharmingen™
Characteristics C-erbB-2 (also known as HER2/neu), a 185 kDa transmembrane glycoprotein, is a member of the type 1 growth factor receptor subfamily which also includes c-erbB-3, c-erbB-4 and the epidermal growth factor receptor (EGFR) (also known as c-erbB-1). Members of this receptor subfamily mediate the proliferation and differentiation of normal cells. They have a common structure consisting of an extracellular domain, a transmembrane region, and a cytoplasmic sequence. The extracellular regions contain two cysteine-rich domains, and the intracellular regions have sequence homology to known tyrosine kinases. C-erbB-3 reactivity has been detected in proximal kidney tubules, mucosal epithelium in the gastointenstinal tract, and squamous epithelium in skin. Most other normal adult tissue show little or no reactivity with antibodies against c-erbB-2, including breast, ovary, spleen, liver, bone marrow, prostate, adrenal, and lung. However, c-erbB-2 is overexpressed in many human breast, stomach, ovary and bladder carcinomas. EGFR, c-erbB-3 and c-erbB-4 are also overexpressed in various human tumor cells, and it is thought that aberrant activation of type 1 growth factor kinase activities may contribute to tumor progression.

BD Pharmingen™ Purified Mouse Anti-Human c-erbB-2 - Purified - Clone 9G6 - Isotype Mouse IgG1 - Reactivity Hu - 100 μg
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Recombinant human c-erbB-2
Clone 9G6
Isotype IgG1
Plasmids, Primers & others

Target Details HER2

Product Details anti-HER2 Antibody Application Details Handling References for anti-HER2 antibody (ABIN2688859) Images back to top
Antigen
Alternative Name C-ErbB-2 (ERBB2 Antibody Abstract)
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development

Application Details

Product Details anti-HER2 Antibody Target Details HER2 Handling References for anti-HER2 antibody (ABIN2688859) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-HER2 Antibody Target Details HER2 Application Details References for anti-HER2 antibody (ABIN2688859) Images back to top
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4°C.

References for anti-HER2 antibody (ABIN2688859)

Product Details anti-HER2 Antibody Target Details HER2 Application Details Handling Images back to top
Product cited in:

Stål, Sullivan, Sun, Wingren, Nordenskjöld: "Simultaneous analysis of c-erbB-2 expression and DNA content in breast cancer using flow cytometry." in: Cytometry, Vol. 16, Issue 2, pp. 160-8, 1994

Carraway, Cantley: "A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling." in: Cell, Vol. 78, Issue 1, pp. 5-8, 1994

Penault-Llorca, Adelaïde, Houvenaeghel, Hassoun, Birnbaum, Jacquemier: "Optimization of immunohistochemical detection of ERBB2 in human breast cancer: impact of fixation." in: The Journal of pathology, Vol. 173, Issue 1, pp. 65-75, 1994

Schwechheimer, Läufle, Schmahl, Knödlseder, Fischer, Höfler: "Expression of neu/c-erbB-2 in human brain tumors." in: Human pathology, Vol. 25, Issue 8, pp. 772-80, 1994

Rubin, Finstad, Wong, Almadrones, Plante, Lloyd: "Prognostic significance of HER-2/neu expression in advanced epithelial ovarian cancer: a multivariate analysis." in: American journal of obstetrics and gynecology, Vol. 168, Issue 1 Pt 1, pp. 162-9, 1993

Singleton, Niehans, Gu, Litz, Hagen, Qiu, Kiang, Strickler: "Detection of c-erbB-2 activation in paraffin-embedded tissue by immunohistochemistry." in: Human pathology, Vol. 23, Issue 10, pp. 1141-50, 1992

van de Vijver, Peterse, Mooi, Wisman, Lomans, Dalesio, Nusse: "Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer." in: The New England journal of medicine, Vol. 319, Issue 19, pp. 1239-45, 1988