anti-Human HER2 antibody for Immunohistochemistry (Frozen Sections)

Recommended HER2 Antibody (supplied by: Log in to see )

Antigen
V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Antibodies
  • CD340
  • HER-2
  • HER-2/neu
  • HER2
  • MLN 19
  • NEU
  • NGL
  • TKR1
  • Erbb-2
  • Neu
  • c-erbB2
  • c-neu
  • mKIAA3023
  • wu:fv70f10
  • zgc:63601
  • erb2
  • erb-b2 receptor tyrosine kinase 2
  • ERBB2
  • Erbb2
  • erbb2
Reactivity
Human
1141
397
278
28
22
8
4
4
4
4
3
3
3
2
1
1
1
Host
Mouse
758
452
32
14
11
3
3
Clonality
Monoclonal
Conjugate
This HER2 antibody is un-conjugated
53
45
38
37
36
21
19
19
12
12
12
10
10
8
8
8
8
8
7
7
7
7
7
7
7
7
6
6
6
3
2
2
1
Application
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunoprecipitation (IP)
625
464
336
305
276
207
195
107
106
102
91
24
21
18
18
6
4
4
3
3
3
2
1
1
1
1
1
1
1
Options
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Catalog No. ABIN2688859
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN967459 IHC (fro) IHC (p) IP WB Mouse IgG1 AA 1242-1255 Log in to see 3B5 9
1 ABIN305740 IHC IHC (fro) IHC (p) IP WB Rabbit IgG AA 1243-1255 Log in to see Polyclonal 0
1 ABIN372478 IHC (fro) IHC (p) IP WB Rabbit IgG AA 1243-1255 Log in to see Polyclonal 0
1 ABIN959522 IHC IHC (fro) IHC (p) IP WB Mouse IgG1 Log in to see 3B5 0
1 ABIN115291 IHC (fro) IHC (p) Rabbit Log in to see Polyclonal 3
1 ABIN1101368 FACS IEM IF IHC IHC (fro) IHC (p) IP WB Mouse IgG1 Log in to see 9G6 0
1 ABIN385331 FACS IF IHC IHC (fro) IP Mouse IgG1 Extracellular Domain Log in to see 9G6-10 0
1 ABIN115290 IHC (fro) IHC (p) Rabbit Log in to see Polyclonal 1
1 ABIN1734112 IHC (fro) IHC (p) IP WB Rabbit IgG AA 1243-1255 Log in to see Polyclonal 0
1 ABIN1839951 IEM IF IHC IHC (fro) Biotin Mouse IgG1 Extracellular Domain Log in to see N12 0
1 ABIN385541 IEM IF IHC IHC (fro) Mouse IgG1 Extracellular Domain Log in to see N12 0
1 ABIN319888 IHC (fro) Rat IgG2b Log in to see ICR52 2
1 ABIN119012 IHC (fro) Rat IgG2b Log in to see ICR52 2
1 ABIN112219 IHC (fro) IF IHC (p) RIA WB Mouse IgG1 Log in to see CB11 2
1 ABIN4309156 ELISA FACS ICC IF IHC (fro) WB Alexa Fluor 405 Mouse IgG1 kappa Log in to see HRB2-451 0
1 ABIN4309158 ELISA FACS ICC IF IHC (fro) WB Alexa Fluor 647 Mouse IgG1 kappa Log in to see HRB2-451 0
1 ABIN4309159 ELISA FACS ICC IF IHC (fro) WB Alexa Fluor 700 Mouse IgG1 kappa Log in to see HRB2-451 0
1 ABIN4309162 ELISA FACS ICC IF IHC (fro) WB DyLight 650 Mouse IgG1 kappa Log in to see HRB2-451 0
1 ABIN4309163 ELISA FACS ICC IF IHC (fro) WB DyLight 680 Mouse IgG1 kappa Log in to see HRB2-451 0
1 ABIN4309170 ELISA FACS ICC IF IHC (fro) WB DyLight 350 Mouse IgG1 kappa Log in to see HRB2-451 0

General

Antigen V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Antibodies
Reactivity Human
(1141), (397), (278), (28), (22), (8), (4), (4), (4), (4), (3), (3), (3), (2), (1), (1), (1)
Host Mouse
(758), (452), (32), (14), (11), (3), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate This HER2 antibody is un-conjugated
(53), (45), (38), (37), (36), (21), (19), (19), (12), (12), (12), (10), (10), (8), (8), (8), (8), (8), (7), (7), (7), (7), (7), (7), (7), (7), (6), (6), (6), (3), (2), (2), (1)
Application Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunoprecipitation (IP)
(625), (464), (336), (305), (276), (207), (195), (107), (106), (102), (91), (24), (21), (18), (18), (6), (4), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 7 references available
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Product Details anti-HER2 Antibody

Target Details HER2 Application Details Handling References for anti-HER2 antibody (ABIN2688859) Images
Brand BD Pharmingen™
Characteristics C-erbB-2 (also known as HER2/neu), a 185 kDa transmembrane glycoprotein, is a member of the type 1 growth factor receptor subfamily which also includes c-erbB-3, c-erbB-4 and the epidermal growth factor receptor (EGFR) (also known as c-erbB-1). Members of this receptor subfamily mediate the proliferation and differentiation of normal cells. They have a common structure consisting of an extracellular domain, a transmembrane region, and a cytoplasmic sequence. The extracellular regions contain two cysteine-rich domains, and the intracellular regions have sequence homology to known tyrosine kinases. C-erbB-3 reactivity has been detected in proximal kidney tubules, mucosal epithelium in the gastointenstinal tract, and squamous epithelium in skin. Most other normal adult tissue show little or no reactivity with antibodies against c-erbB-2, including breast, ovary, spleen, liver, bone marrow, prostate, adrenal, and lung. However, c-erbB-2 is overexpressed in many human breast, stomach, ovary and bladder carcinomas. EGFR, c-erbB-3 and c-erbB-4 are also overexpressed in various human tumor cells, and it is thought that aberrant activation of type 1 growth factor kinase activities may contribute to tumor progression.

BD Pharmingen™ Purified Mouse Anti-Human c-erbB-2 - Purified - Clone 9G6 - Isotype Mouse IgG1 - Reactivity Hu - 100 μg
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Recombinant human c-erbB-2
Clone 9G6
Isotype IgG1

Target Details HER2

Product Details anti-HER2 Antibody Application Details Handling References for anti-HER2 antibody (ABIN2688859) Images back to top
Antigen
Alternative Name C-ErbB-2 (ERBB2 Antibody Abstract)
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development

Application Details

Product Details anti-HER2 Antibody Target Details HER2 Handling References for anti-HER2 antibody (ABIN2688859) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-HER2 Antibody Target Details HER2 Application Details References for anti-HER2 antibody (ABIN2688859) Images back to top
Concentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store undiluted at 4°C.

References for anti-HER2 antibody (ABIN2688859)

Product Details anti-HER2 Antibody Target Details HER2 Application Details Handling Images back to top
Product cited in:

Stål, Sullivan, Sun, Wingren, Nordenskjöld: "Simultaneous analysis of c-erbB-2 expression and DNA content in breast cancer using flow cytometry." in: Cytometry, Vol. 16, Issue 2, pp. 160-8, 1994

Carraway, Cantley: "A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling." in: Cell, Vol. 78, Issue 1, pp. 5-8, 1994

Penault-Llorca, Adelaïde, Houvenaeghel, Hassoun, Birnbaum, Jacquemier: "Optimization of immunohistochemical detection of ERBB2 in human breast cancer: impact of fixation." in: The Journal of pathology, Vol. 173, Issue 1, pp. 65-75, 1994

Schwechheimer, Läufle, Schmahl, Knödlseder, Fischer, Höfler: "Expression of neu/c-erbB-2 in human brain tumors." in: Human pathology, Vol. 25, Issue 8, pp. 772-80, 1994

Rubin, Finstad, Wong, Almadrones, Plante, Lloyd: "Prognostic significance of HER-2/neu expression in advanced epithelial ovarian cancer: a multivariate analysis." in: American journal of obstetrics and gynecology, Vol. 168, Issue 1 Pt 1, pp. 162-9, 1993

Singleton, Niehans, Gu, Litz, Hagen, Qiu, Kiang, Strickler: "Detection of c-erbB-2 activation in paraffin-embedded tissue by immunohistochemistry." in: Human pathology, Vol. 23, Issue 10, pp. 1141-50, 1992

van de Vijver, Peterse, Mooi, Wisman, Lomans, Dalesio, Nusse: "Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer." in: The New England journal of medicine, Vol. 319, Issue 19, pp. 1239-45, 1988