Browse our anti-IGF1 (IGF1) Antibodies

Human Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. Systematic literature review indicates IGF-1 concentrations do not confer additional diagnostic information for individuals with cognitive decline.

2. Results found that LGF1 mRNA was increased in prenatally exposed female children to intrauterine or early-life cigarette smoke.

3. These results demonstrated that E-domains are regulatory elements that control IGF-1 production and secretion.

4. PRMT1 became activated upon IGF-1 stimulation.

5. IGF-1/ IGF-1R SNPs may contribute to the genetic susceptibility to hypertension in a Han Chinese population.

6. the reduced serum IGF-1 associated with hepatic osteodystrophy is a main determinant of low cortical but not trabecular bone mass.

7. Low IGF-1 was robustly associated with high soluble CD163 and CD14 in HIV-infected patients.

8. Data show that the serum insulin like growth factor 1 (IGF-1) concentrations were within the lower normal range (41.7% cases), and 58.3% results were below the normal reference range, and the average serum insulin-like growth factor binding protein type 3 (IGFBP-3 ) levels were within the lower normal range.

9. Differential expression of LIF and IGF-1 in molar trophoblasts and chorionic villi might have a role in regulation of trophoblasts in complete moles. Decreased expression of glandular IGF-1 and decidual LIF might be related to the decidual changes during trophoblastic proliferation and invasion of decidua in complete HMs.

10. In contrast to data from animal models, low IGF-I levels are associated with higher mortality in older humans. Irrespective of the actual IGF-I level, older individuals with stability of IGF-I levels have lower mortality than those whose IGF-I levels fluctuate over time.

11. This latter effect disappears when both rictor and mTOR are inhibited, showing that the mTORC2 effect is mTORC1 dependent. This study has expanded the role of mTOR in DPSCs neural differentiation regulated by IGF-1.

12. the impact of hormonal alterations, with special focus on low Triiodothyronine and IGF-1 levels, on antioxidant systems as a link with osteoporosis in Functional Hypothalamic Amenorrhea, is reported.

13. Study provides evidence that IGF1 rs2195239 and rs2162679 polymorphisms were associated with overall cancer risk.

14. Mechano-growth factor regulates cyclic stretch-induced osteogenic differentiation and MMP-1, MMP-2 expression in human periodontal ligament cells by activating MEK/ERK1/2 signaling pathway.

15. IGF-1 shows a binding specificity for G-quadruplex structures, especially the G-quadruplex structure with a parallel topology

16. findings support the possible role of CA repeat polymorphism in IGF1 gene promoter in CRC risk

17. we aimed to evaluate serum levels of IGF-1, IGF-2 and IGF-binding protein 3 (IGF-BP3) before and after standard treatment in patients with advanced non-small cell lung cancer (NSCLC) and their prognostic and predictive correlations.

18. these findings indicated that IGF1 is able to upregulate PPARgamma by activating the IGF1R and PI3K pathways, thereby accelerating lipogenesis and enhancing IH HemSC adipogenesis.

19. study of association of IGFBP3 and IGF1 polymorphisms with susceptibility to colorectal cancer [Meta-analysis]

20. IGF-1 polymorphisms rs35767, rs5742714, and rs972936 show significant association with ONFH risk. Genotype AA and allele A of polymorphism rs35767 offered protection for osteonecrosis of the femoral head (ONFH), while the polymorphism rs972936 significantly enhanced the disease risk. Haplotype analysis demonstrated that C-T could increase ONFH risk while G-T might be a protective factor for ONFH in a Chinese Han group.

Mouse (Murine) Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. It confirmed this mechanism is operative in human disease and show that enforced IGF1 signaling effectively limits leukemia stem cell activity.

2. Results found that LGF1 mRNA was increased in female murine offspring exposed to intrauterine smoke.

3. NK cell potentiation by G-F1 was antagonized by insulin-like growth factor (IGF)-1 blockade and recapitulated by IGF-1 treatment, suggesting the involvement of IGF-1.

4. These data demonstrate a specific role for IGF-I in maintaining muscle homeostasis in adults.

5. Findings shed light on the in vivo roles of IEC-specific IGF1 in intestinal homeostasis, epithelial regeneration, and immunity, broadening our current insights on IGF1 functions.

6. our data reveal a distinct role of IGF-1 in regulating thrombopoiesis, providing new insights into TPO-independent regulation of platelet generation.

7. Loss of IGF1 expression is associated with impaired growth and progressively disrupted glucose homeostasis .

8. High IGF1 expression is associated with Peripheral pain in type 2 diabetes mellitus.

9. In this study, we investigated the proliferation, migration, and growth factor expression of human dermal papilla (DP) cells in the presence or absence of treatment with mesenchymal stem cell extracellular vesicles (MSC-EVs)..DP cells treated with MSC-EVs displayed increased expression and secretion of VEGF and IGF-1.

10. AMderived IGF1 may serve an important role in the regulation of airway inflammation and remodeling in asthmatic mice.

11. IGF-1 regulates clock gene expression and that GSK-3beta but not ERK-1/2 is required for the IGF-1-mediated regulation of the Bmal-1 promoter in hypothalamic cells.

12. In osteocytes (but not osteoblasts), miR-29b-3p was responsive to the mechanical tensile strain and regulated osteoblast differentiation via regulating IGF-1 secretion of mechanically strained osteocytes.

13. hese data identify that dopamine neuron-derived IGF-1 acts as a regulator of dopamine neurons and regulates dopamine-mediated behaviors.

14. results indicate that myeloid p38alpha through the production of IGF-1 controls colon inflammation and tumorigenesis

15. results point to a new TTR role through the IGF-I axis, mediated through TTR-IGF-IR interactions.

16. circulating IGF-I appears to be involved in mood homeostasis across different species; IGF-I may be acting at least in part by modulating FKBP5 expression

17. Although IGF1 treatment improved growth of Noonan syndrome (NS) mice, it did not fully reverse growth plate abnormalities, notably the decreased hypertrophic zone.

18. The results of the present study demonstrated that IGF1 may improve neuropathy in diabetic mice

19. Adipocyte-specific IGF-I ablation in obese Berlin Fat Mouse Inbred mice results in reduced adipose tissue mass and thereby alters glucose metabolism.

20. IGF-1 upregulated c-kit expression in c-kit-positive C-kit-positive cardiac stem cells (CSCs) resulting in enhanced CSC proliferation and migration by activating the PI3K/AKT/DNMT signaling pathway to epigenetically silence miR-193a, which negatively modifies the c-kit expression level.

Pig (Porcine) Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. This finding confirmed that miR-511 inhibits proliferation and promotes apoptosis by downregulating the IGF-1 in PK-15 cells.

2. High temperature, independent feed intake reduction, increases IGF-1:IGFBP-3 ratio.

3. the dipeptide Pro-Asp promoted IGF-1 secretion and expression in hepatocytes.

4. The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg. In summary, PPARg plays an important role in the regulation of IGF-1 secretion and gene expression in response to dietary protein.

5. Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system.

6. This study demonstrated that Up-regulation of IGF-1 in the frontal cortex of piglets exposed to an environmentally enriched arena.

7. Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model.

8. Results show that expression changes of IGF1 genes were associated with C/EBP b expression during embryonic and postnatal development in porcine liver.

9. genetic association study suggests that the TC genotype of IGF-1 represents the selection genotype for smaller in size.

10. IGF-I coordinately regulates multiple cell signaling pathways that are critical to proliferation, migration and survival of trophectoderm cells during early pregnancy in pigs.

11. IGF-1 splice variant (mechano growth factor) is expressed within the growth plate, but the addition of its peptides was not associated with growth plate chondrocytes proliferation.

12. alpha-linolenic acid increased IGF-I secretion from hepatocytes.

13. Copper can stimulate chondrocyte proliferation by promoting the expression of IGF-1.

14. The results show that modulation of plasma insulin levels by dietary carbohydrates seems possible in anabolic sows, but IGF-I levels are less easily modified.

15. The results suggested that IFG-1 and -2 and their receptors are differentially expressed at the maternal and fetal components of the attachment site.

16. Plasma ghrelin level and myocardial IGF-1 mRNA expression were significantly up-regulated, while plasma IGF-1 level and myocardial ghrelin mRNA expression were down-regulated in the chronic cyanotic immature piglets.

17. IGFI signaling pathway regulates myofibre hypertrophy postnatally via complicated signal effectors, which may have negative impact on meat quality simultaneously.

18. IGF-I, IGF-II, and IGFBP-3 mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.

19. These results indicate that sorbic acid improves growth performance by regulating IGF system gene expression and hormone secretion.

20. In an animal model of acute myocardial infarction relevant to human disease, intracoronary administration of IGF-1/hepatocyte growth factor (HGF) is a practical and effective strategy to reduce pathological cardiac remodeling.

Rabbit Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. Data suggest caloric restriction modifies response of ovarian granulosa cells to leptin on cell proliferation/apoptosis, MAP kinase signaling, and release of hormones (estradiol and IGFI). The caloric restriction studies were conducted in rabbits; then, isolated rabbit granulosa cells were exposed to recombinant human leptin. (IGF1 = insulin-like growth factor I)

2. Intraplacental gene therapy with Ad-IGF-1 corrects naturally occurring rabbit model of intrauterine growth restriction.

3. Our studies demonstrate that the active SVCT2 is expressed in IVD cells and that the expression of this transporter is regulated by growth factors IGF-1 and dexamethasone.

4. increased endogenous IGF1 and IGF2 expression by the blastocyst compensates for the loss of systemic insulin and IGF.

5. IGF1 showed a significantly higher capacity to form the posterior mesoderm and primitive streak (stage 2 and 3) than blastocysts cultured without growth factors

6. Overall, IGF-1 promoted atherosclerosis by affecting endothelial function and aging.

Rainbow Trout (Oncorhynchus mykiss) Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. Findings show similar regulatory growth hormone (GH) and insulin-like growth factor 1 (IGF-1) responses in both Atlantic salmon and rainbow trout.

2. the present study assessed the combined impacts of estrogens and bacterial infection on the insulin-like growth factors (IGF) and tumor-necrosis factor (TNF)-alpha.

3. Nutrient availability, IGF-I, and genetic variation affect weight loss, in part through alterations of proteolytic pathways in rainbow trout.

Zebrafish Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. Data show that a group of epithelial cells expressing insulin-like growth factor binding protein 5a (igfbp5a) take up Ca(2+) and proliferate under low Ca(2+) conditions because of activation of insulin like growth factors (IGF) signaling.

2. Results suggest that locally derived intra-ovarian IGF1 may have a role in the differentiation and growth of primary follicles in zebrafish ovary.

3. Study demonstrated that IGF-I can stimulate egfr expression in both follicles cell culture and intact follicles promoting oocyte maturation.

4. IGF-I-induced kitlga expression is inhibited by epidermal growth factor, an oocyte-derived paracrine factor in the zebrafish follicle.

5. hypoxia causes PGC migration defect by inhibiting IGF signaling through the induction of IGFBP-1

6. amphioxus and zebrafish both share a similar regulatory mechanism of IGF gene expression in response to T(3), providing an evidence for the presence of a vertebrate-like TH/IGF signaling pathway in the protochordate amphioxus.

7. Whereas hypoxia repressed the Igf1 receptor and its downstream Erk1/2 and Akt signaling activities, re-oxygenation restored their activities

8. IGF signalling influences expression of BMP2b, a gene that plays an important role in zebrafish pattern formation

9. The insulin-like growth factor 1 gene can be differentially transcribed to yield two distinct IGF-1 mRNA transcripts

10. zebrafish XBP-1 spliced form not only activates genes responsible for protein folding, transporting, glycosylation and Endoplasmic Reticulum associated degradation but also activates anti-apoptosis signal via IGF1/Akt pathway in unfolded protein

11. zebrafish primordial germ cells intrinsically require IGF signaling for directional migration in vivo

Cow (Bovine) Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. LncRNA H19 participated in the regulation of the proliferation and apoptosis of male germline stem cells via the IGF-1 signaling pathway

2. plasma insulin-like peptide 3, testosterone, inhibin, and insulin-like growth factor-I have a relationship with scrotal circumference and testicular weight in Japanese Black beef bull calves

3. These results suggest that reduced secretions of IGF-I, INSL3, and inhibin surrounding puberty may be associated with semen aberration in beef bulls.

4. IGF1/RsaI was associated with average daily weight gain in cattle.

5. Thus CR suppresses the hypertrophic PGC1alpha-4/IGF-1/AKT1 pathway while promoting activation of the calpain system.

6. Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system.

7. IGF1 single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle.

8. It has been shown that several specific genes which are differentially regulated, including IGF-1, might impact dairy fertility.

9. There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.

10. Associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle.

11. The association of IGF1, GH, and PIT1 markers with growth and reproductive traits were assessed.

12. These findings strongly support the concept that IGF-1 upregulates LHR expression in granulosa cells and that IGF-1 is required for determining which follicle becomes dominant and acquires ovulatory capacity.

13. Insulin-induced glucose uptake in lactating bovine mammary epithelial cells may involve the phosphatidylinositide 3-kinase- but not mitogen-activated protein kinase-mediated signaling pathways.

14. Data show that individuals with insulin-like growth factor I (IGF-1) allele C had a significantly higher performance in production traits.

15. Uterine concentrations of IGFBPs are cycle stage specific and also suggests IGF1-dependent and -independent functions for IGFBPs during a time of major change in the developing embryo.

16. This study evaluated the relationship of IGF-I levels to several other determinants of feed intake in Red Angus cross cattle.

17. Production and reproduction traits in Holstein cattle associated with single nucleotide polymorphisms in the IGF1 gene.

18. There is a strong association between putative favorable allelic variants (SNP) of neuropeptide Y, leptin, and IGF-1 genes, and residual feed intake, when animals were grazing on a high-quality, high-availability pasture.

19. Direct additive genetic correlations suggest that selection for greater IGF-I concentration could lead to increased conception rate and calving rate, and decreased age at first calving in heifers.

20. We found that IGF-I stimulated chondrocyte biosynthesis similarly when delivered by either exogenous or endogenous means.

Horse (Equine) Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. Data suggest that metabolism of IGF1, IGF2, and IGFBP3 (insulin-like growth factor binding protein-3) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).

2. The laminar cell types expressing insulin receptor and/or insulin-like growth factor-1 receptor and the effect of dietary carbohydrates on their expression are reported.

3. Increased expression of IGF-1 in female equine embryos. Sex-related influences on expression of the IGF system are probably related to a gradual X chromosome inactivation.

4. Somatomedin (IGF-I) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor is present in spermatogonia, spermatocytes and Leydig cells.

5. Hsp90 inhibitor geldanamycin is used to assess age-related responses with IGF1 stimulation of chondrocytes.

Guinea Pig Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. Local IGF-1 might play a role in the lesion- and deafness-induced plasticity in FC and at AN/FC synapse following chronic kanamycin-induced deafness.

Goat Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. Relative expression of IGF1 was highest in uterus and liver (P < 0.05), followed by oviduct and muscle. This work provided an important experimental basis for further research on the functions of IGF1 in goats.

2. These results suggest the significant influence of the IGF1 gene on prolificacy in goats and identified SNPs would benefit the selection of prolific animals in future breeding programs.

Duck Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. Relative levels of IGF-I and MSTN mRNA may participate in ordering duck muscle growth rates with selected development.

2. Our data indicate a differential expression of selected genes that comprise the IGF system in the duck liver tissue during embryonic and early PH growth and development.

Xenopus laevis Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. Thus, IGF-1 affects only adult-type myogenic cells in the presence of T3 and helps accelerate dorsal muscle remodeling during metamorphosis.