Browse our anti-IGF1 (IGF1) Antibodies

Human Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. study of association of IGFBP3 and IGF1 polymorphisms with susceptibility to colorectal cancer [Meta-analysis]

2. IGF-1 polymorphisms rs35767, rs5742714, and rs972936 show significant association with ONFH risk. Genotype AA and allele A of polymorphism rs35767 offered protection for osteonecrosis of the femoral head (ONFH), while the polymorphism rs972936 significantly enhanced the disease risk. Haplotype analysis demonstrated that C-T could increase ONFH risk while G-T might be a protective factor for ONFH in a Chinese Han group.

3. Results find that IGF-IEc isoform expression is elevated in thyroid cancer and positively associated with more advanced stages of papillary thyroid cancer.

4. IGF-1 binds to IGF-1 receptor (IGF1R) and insulin receptor (IR), activating cancer hallmark pathways.

5. Role of IGF-1 and mTOR in Ageing and Age-Related Disease

6. Study investigating associations between human seminal plasma levels of growth hormone (GH) and IGF-1 and sperm parameters revealed a possible association between GH and asthenozoospermia. IGF-1 seminal level presented no significant association with the sperm parameters examined.

7. This study establishes a new role for IRS-1 as an endocytic regulator of IGF-IR that ensures sustained IGF bioactivity, independent of its classic role as an adaptor in IGF-IR signaling.

8. There exist associations of GH and IGF-1 burden with echocardiography abnormalities and cardiac complications in acromegaly patients

9. Results suggest that the methylation of IGF1 CpG-137 contributes to the individual variation of fetal growth by regulating IGF1 expression in fetal tissues.

10. p53 protein plays a key role in the aging of melanocytes via IGF1 signaling pathways.

11. found a stimulatory effect of acute and chronic exercises on plasma IGF-I and Klotho and association of IGF-I with exercise-induced cardiac hypertrophy.

12. low individual mean serum level associated with progression of retinopathy independently of HbA1c, age, gender, and diabetes duration

13. Low IGF1 expression is associated with non-alcoholic fatty liver disease.

14. No evidence for an association between circulating concentrations of IGF-I measured in adulthood and the risk of melanoma.

15. genotypes CA(19)/CA(19) and CA(19)/CA(19) + CA(>19)/CA(n) of the IGF-1 CA(n) may be considered a risk for endometrial polyp, whereas the genotypes CG and CG + GG of IGFBP3 rs2854746 polymorphism have an inverse effect of endometrial polyp risk.

16. Exogenous insulin-like growth factor 1 (IGF-1) treatment could reverse the effect of miR-99a. MiR-99a could attenuate proliferation and promote apoptosis of human GCs through targeting IGF-1R, which could partly explain the abnormal folliculogenesis in polycystic ovary syndrome.

17. this study shows sex-dependent deficiency in serum IGF-1 in boys with early juvenile idiopathic arthritis

18. Data showed interaction of n-6 fatty acids with IGF-1 and growth during the first 4 months of life, and an association between mead acid and birth size when adjusted for confounding factors.

19. The serum concentrations of IGF-1 and insulin-like growth factor-binding protein 3 (IGFBP-3) was assessed in patients with Crohn disease and with ulcerative colitis.

20. An association was found between IGF-1 polymorphisms and risk of osteoporosis in Chinese post-menopausal women.

Mouse (Murine) Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. AMderived IGF1 may serve an important role in the regulation of airway inflammation and remodeling in asthmatic mice.

2. IGF-1 regulates clock gene expression and that GSK-3beta but not ERK-1/2 is required for the IGF-1-mediated regulation of the Bmal-1 promoter in hypothalamic cells.

3. In osteocytes (but not osteoblasts), miR-29b-3p was responsive to the mechanical tensile strain and regulated osteoblast differentiation via regulating IGF-1 secretion of mechanically strained osteocytes.

4. hese data identify that dopamine neuron-derived IGF-1 acts as a regulator of dopamine neurons and regulates dopamine-mediated behaviors.

5. results indicate that myeloid p38alpha through the production of IGF-1 controls colon inflammation and tumorigenesis

6. results point to a new TTR role through the IGF-I axis, mediated through TTR-IGF-IR interactions.

7. circulating IGF-I appears to be involved in mood homeostasis across different species; IGF-I may be acting at least in part by modulating FKBP5 expression

8. Although IGF1 treatment improved growth of Noonan syndrome (NS) mice, it did not fully reverse growth plate abnormalities, notably the decreased hypertrophic zone.

9. The results of the present study demonstrated that IGF1 may improve neuropathy in diabetic mice

10. Adipocyte-specific IGF-I ablation in obese Berlin Fat Mouse Inbred mice results in reduced adipose tissue mass and thereby alters glucose metabolism.

11. IGF-1 upregulated c-kit expression in c-kit-positive C-kit-positive cardiac stem cells (CSCs) resulting in enhanced CSC proliferation and migration by activating the PI3K/AKT/DNMT signaling pathway to epigenetically silence miR-193a, which negatively modifies the c-kit expression level.

12. glucagon and/or IGF-1 production are additional key factors in food-induced entrainment.

13. Combined treatment with electrical stimulation and insulin-like growth factor-1 promotes bone regeneration in vitro.

14. Enteric neural stem cells expressing IGF1 has been proposed as a novel cellular therapy for Hirschsprung's Disease tested in a mouse model.

15. Deficiency in the liver-derived IGF-I does not affect wound healing in mice, neither in normoglycemic conditions nor in diabetes.

16. diabetic gastroparesis was an aggressive process due to the successive damages of myenteric cholinergic neurones and ICC by impairing the insulin/InsR and IGF-1/IGF-1R signaling. Insulin therapy in the early stage may delay diabetic gastroparesis

17. these results indicate that IGF-I induces senescence of hepatic stellate cells, inactivates these cells and limits fibrosis in a p53-dependent manner and that IGF-I may be applied to treat nonalcoholic steatohepatitis and cirrhosis.

18. IGF-1 is involved in hepatic mitochondrial protection, because it is able to reduce free radical production, oxidative damage and apoptosis. All these IGF-1 actions are mediated by the modulation of the expression of genes encoding citoprotective and antiapoptotic proteins.

19. Inhibition of mammalian target of rapamycin (mTOR) activation using rapamycin restored Mb mRNA expression to control levels. Lipid supplementation had no effect on Mb gene expression. Thus, IGF-1-induced anabolic signaling can be a strategy to improve muscle size under mild hypoxia, but lowers Mb gene expression

20. Macrophage subtypes enhanced the osteogenesis in transwell setting and the transition from M1 to M2 was associated with an increase in bone anabolic factors CCL2/MCP-1, CCL5/RANTES and IGF-1 in vitro.

Pig (Porcine) Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. High temperature, independent feed intake reduction, increases IGF-1:IGFBP-3 ratio.

2. the dipeptide Pro-Asp promoted IGF-1 secretion and expression in hepatocytes.

3. The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg. In summary, PPARg plays an important role in the regulation of IGF-1 secretion and gene expression in response to dietary protein.

4. Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system.

5. This study demonstrated that Up-regulation of IGF-1 in the frontal cortex of piglets exposed to an environmentally enriched arena.

6. Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model.

7. Results show that expression changes of IGF1 genes were associated with C/EBP b expression during embryonic and postnatal development in porcine liver.

8. genetic association study suggests that the TC genotype of IGF-1 represents the selection genotype for smaller in size.

9. IGF-I coordinately regulates multiple cell signaling pathways that are critical to proliferation, migration and survival of trophectoderm cells during early pregnancy in pigs.

10. IGF-1 splice variant (mechano growth factor) is expressed within the growth plate, but the addition of its peptides was not associated with growth plate chondrocytes proliferation.

11. alpha-linolenic acid increased IGF-I secretion from hepatocytes.

12. Copper can stimulate chondrocyte proliferation by promoting the expression of IGF-1.

13. The results show that modulation of plasma insulin levels by dietary carbohydrates seems possible in anabolic sows, but IGF-I levels are less easily modified.

14. The results suggested that IFG-1 and -2 and their receptors are differentially expressed at the maternal and fetal components of the attachment site.

15. Plasma ghrelin level and myocardial IGF-1 mRNA expression were significantly up-regulated, while plasma IGF-1 level and myocardial ghrelin mRNA expression were down-regulated in the chronic cyanotic immature piglets.

16. IGFI signaling pathway regulates myofibre hypertrophy postnatally via complicated signal effectors, which may have negative impact on meat quality simultaneously.

17. IGF-I, IGF-II, and IGFBP-3 mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.

18. These results indicate that sorbic acid improves growth performance by regulating IGF system gene expression and hormone secretion.

19. In an animal model of acute myocardial infarction relevant to human disease, intracoronary administration of IGF-1/hepatocyte growth factor (HGF) is a practical and effective strategy to reduce pathological cardiac remodeling.

20. The expression of IGF-I and IGF-II in native growth plates of prepubertal piglets and under different cell culture conditions, was compared.

Rabbit Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. Data suggest caloric restriction modifies response of ovarian granulosa cells to leptin on cell proliferation/apoptosis, MAP kinase signaling, and release of hormones (estradiol and IGFI). The caloric restriction studies were conducted in rabbits; then, isolated rabbit granulosa cells were exposed to recombinant human leptin. (IGF1 = insulin-like growth factor I)

2. Intraplacental gene therapy with Ad-IGF-1 corrects naturally occurring rabbit model of intrauterine growth restriction.

3. Our studies demonstrate that the active SVCT2 is expressed in IVD cells and that the expression of this transporter is regulated by growth factors IGF-1 and dexamethasone.

4. increased endogenous IGF1 and IGF2 expression by the blastocyst compensates for the loss of systemic insulin and IGF.

5. IGF1 showed a significantly higher capacity to form the posterior mesoderm and primitive streak (stage 2 and 3) than blastocysts cultured without growth factors

6. Overall, IGF-1 promoted atherosclerosis by affecting endothelial function and aging.

Rainbow Trout (Oncorhynchus mykiss) Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. Findings show similar regulatory growth hormone (GH) and insulin-like growth factor 1 (IGF-1) responses in both Atlantic salmon and rainbow trout.

2. the present study assessed the combined impacts of estrogens and bacterial infection on the insulin-like growth factors (IGF) and tumor-necrosis factor (TNF)-alpha.

3. Nutrient availability, IGF-I, and genetic variation affect weight loss, in part through alterations of proteolytic pathways in rainbow trout.

Zebrafish Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. Results suggest that locally derived intra-ovarian IGF1 may have a role in the differentiation and growth of primary follicles in zebrafish ovary.

2. Study demonstrated that IGF-I can stimulate egfr expression in both follicles cell culture and intact follicles promoting oocyte maturation.

3. IGF-I-induced kitlga expression is inhibited by epidermal growth factor, an oocyte-derived paracrine factor in the zebrafish follicle.

4. hypoxia causes PGC migration defect by inhibiting IGF signaling through the induction of IGFBP-1

5. amphioxus and zebrafish both share a similar regulatory mechanism of IGF gene expression in response to T(3), providing an evidence for the presence of a vertebrate-like TH/IGF signaling pathway in the protochordate amphioxus.

6. Whereas hypoxia repressed the Igf1 receptor and its downstream Erk1/2 and Akt signaling activities, re-oxygenation restored their activities

7. IGF signalling influences expression of BMP2b, a gene that plays an important role in zebrafish pattern formation

8. The insulin-like growth factor 1 gene can be differentially transcribed to yield two distinct IGF-1 mRNA transcripts

9. zebrafish XBP-1 spliced form not only activates genes responsible for protein folding, transporting, glycosylation and Endoplasmic Reticulum associated degradation but also activates anti-apoptosis signal via IGF1/Akt pathway in unfolded protein

10. zebrafish primordial germ cells intrinsically require IGF signaling for directional migration in vivo

Cow (Bovine) Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. plasma insulin-like peptide 3, testosterone, inhibin, and insulin-like growth factor-I have a relationship with scrotal circumference and testicular weight in Japanese Black beef bull calves

2. These results suggest that reduced secretions of IGF-I, INSL3, and inhibin surrounding puberty may be associated with semen aberration in beef bulls.

3. IGF1/RsaI was associated with average daily weight gain in cattle.

4. Thus CR suppresses the hypertrophic PGC1alpha-4/IGF-1/AKT1 pathway while promoting activation of the calpain system.

5. Data suggest that both ovarian follicular dominance in cows and cooperation of ovarian follicles in pigs can be mediated by either down- or up-regulation of the insulin-like growth factor 1/oxytocin system.

6. IGF1 single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle.

7. It has been shown that several specific genes which are differentially regulated, including IGF-1, might impact dairy fertility.

8. There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system.

9. Associations between genetic variants in the promoter region of the insulin-like growth factor-1 (IGF1) gene and blood serum IGF1 concentration in Hanwoo cattle.

10. The association of IGF1, GH, and PIT1 markers with growth and reproductive traits were assessed.

11. These findings strongly support the concept that IGF-1 upregulates LHR expression in granulosa cells and that IGF-1 is required for determining which follicle becomes dominant and acquires ovulatory capacity.

12. Insulin-induced glucose uptake in lactating bovine mammary epithelial cells may involve the phosphatidylinositide 3-kinase- but not mitogen-activated protein kinase-mediated signaling pathways.

13. Data show that individuals with insulin-like growth factor I (IGF-1) allele C had a significantly higher performance in production traits.

14. Uterine concentrations of IGFBPs are cycle stage specific and also suggests IGF1-dependent and -independent functions for IGFBPs during a time of major change in the developing embryo.

15. This study evaluated the relationship of IGF-I levels to several other determinants of feed intake in Red Angus cross cattle.

16. Production and reproduction traits in Holstein cattle associated with single nucleotide polymorphisms in the IGF1 gene.

17. There is a strong association between putative favorable allelic variants (SNP) of neuropeptide Y, leptin, and IGF-1 genes, and residual feed intake, when animals were grazing on a high-quality, high-availability pasture.

18. Direct additive genetic correlations suggest that selection for greater IGF-I concentration could lead to increased conception rate and calving rate, and decreased age at first calving in heifers.

19. We found that IGF-I stimulated chondrocyte biosynthesis similarly when delivered by either exogenous or endogenous means.

20. Results herein remark the important role of the IGF-1gene in the fertility of dairy cows on early lactation and make the SNP IGF-1/SnaBI an interesting candidate marker for genetic improvement of fertility in dairy cattle.

Horse (Equine) Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. Data suggest that metabolism of IGF1, IGF2, and IGFBP3 (insulin-like growth factor binding protein-3) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).

2. The laminar cell types expressing insulin receptor and/or insulin-like growth factor-1 receptor and the effect of dietary carbohydrates on their expression are reported.

3. Increased expression of IGF-1 in female equine embryos. Sex-related influences on expression of the IGF system are probably related to a gradual X chromosome inactivation.

4. Somatomedin (IGF-I) is localized in equine spermatogenic and Leydig cells, and IGF-I receptor is present in spermatogonia, spermatocytes and Leydig cells.

5. Hsp90 inhibitor geldanamycin is used to assess age-related responses with IGF1 stimulation of chondrocytes.

Guinea Pig Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. Local IGF-1 might play a role in the lesion- and deafness-induced plasticity in FC and at AN/FC synapse following chronic kanamycin-induced deafness.

Goat Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. Relative expression of IGF1 was highest in uterus and liver (P < 0.05), followed by oviduct and muscle. This work provided an important experimental basis for further research on the functions of IGF1 in goats.

2. These results suggest the significant influence of the IGF1 gene on prolificacy in goats and identified SNPs would benefit the selection of prolific animals in future breeding programs.

Duck Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. Relative levels of IGF-I and MSTN mRNA may participate in ordering duck muscle growth rates with selected development.

2. Our data indicate a differential expression of selected genes that comprise the IGF system in the duck liver tissue during embryonic and early PH growth and development.

Xenopus laevis Insulin-Like Growth Factor 1 (IGF1) interaction partners

1. Thus, IGF-1 affects only adult-type myogenic cells in the presence of T3 and helps accelerate dorsal muscle remodeling during metamorphosis.