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Submit your validation data for this product and get a full refund. I want to validate this productRelevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
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8.54849 | ABIN4321576 | ICC IF WB | Rabbit | AA 700-800, Internal Region | Log in to see | Polyclonal | 1 | |||
-12.758193 | ABIN4321575 | ICC IF WB | Rabbit | AA 700-800, Internal Region | Log in to see | Polyclonal | 0 | |||
-12.758193 | ABIN4321587 | ICC IF | FITC | Rabbit | AA 700-800, Internal Region | Log in to see | Polyclonal | 0 | ||
-12.758193 | ABIN4321590 | ICC IF WB | Alexa Fluor 405 | Rabbit | AA 700-800, Internal Region | Log in to see | Polyclonal | 0 | ||
-12.758193 | ABIN4321589 | ICC IF WB | DyLight 405 | Rabbit | AA 700-800, Internal Region | Log in to see | Polyclonal | 0 | ||
-12.758193 | ABIN4321593 | ICC IF WB | Alexa Fluor 700 | Rabbit | AA 700-800, Internal Region | Log in to see | Polyclonal | 0 | ||
-12.758193 | ABIN4321583 | ICC IF WB | DyLight 488 | Rabbit | AA 700-800, Internal Region | Log in to see | Polyclonal | 0 | ||
-12.758193 | ABIN4321585 | ICC IF WB | DyLight 550 | Rabbit | AA 700-800, Internal Region | Log in to see | Polyclonal | 0 | ||
-12.758193 | ABIN4321581 | ICC IF WB | Biotin | Rabbit | AA 700-800, Internal Region | Log in to see | Polyclonal | 0 | ||
-12.758193 | ABIN4321582 | ICC IF WB | DyLight 650 | Rabbit | AA 700-800, Internal Region | Log in to see | Polyclonal | 0 | ||
-12.758193 | ABIN4321591 | ICC IF WB | Alexa Fluor 488 | Rabbit | AA 700-800, Internal Region | Log in to see | Polyclonal | 0 | ||
-12.758193 | ABIN4321592 | ICC IF WB | Alexa Fluor 647 | Rabbit | AA 700-800, Internal Region | Log in to see | Polyclonal | 0 |
General |
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Antigen | Insulin-Like Growth Factor 1 Receptor (IGF1R) Antibodies |
Epitope | Middle Region Alternatives |
Reactivity | Cow (Bovine), Dog (Canine), Horse (Equine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus), Sheep (Ovine), Zebrafish (Danio rerio) Alternatives |
Host | Rabbit Alternatives |
Clonality | |
Conjugate | This IGF1R antibody is un-conjugated Alternatives |
Application |
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
Alternatives
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2 references available |
Supplier | Log in to see |
Product Details anti-IGF1R AntibodyTarget Details IGF1R Application Details Handling References for anti-IGF1R antibody (ABIN2792087) Images |
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Sequence | DRHSGHKAEN GPGPGVLVLR ASFDERQPYA HMNGGRKNER ALPLPQSSTC |
Specificity | Directed to the beta chain of IGF1R |
Predicted Reactivity | Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Pig: 100%, Rat: 92%, Sheep: 100%, Zebrafish: 100% |
Characteristics | This is a rabbit polyclonal antibody against IGF1R. It was validated on Western Blot using a cell lysate as a positive control. |
Purification | Affinity Purified |
Immunogen | The immunogen is a synthetic peptide directed towards the middle region of human IGF1R |
Plasmids, Primers & others | |
Target Details IGF1RProduct Details anti-IGF1R Antibody Application Details Handling References for anti-IGF1R antibody (ABIN2792087) Images back to top |
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Antigen | |
Alternative Name | IGF1R (IGF1R Antibody Abstract) |
Background |
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-140 DR007209.1 566-705 141-3559 X04434.1 136-3554 3560-4540 BC113610.1 3542-4522 4541-4921 DA486252.1 187-567 4922-5392 BX093045.1 248-718 5393-5768 CN414655.1 317-692 5769-6158 BM264223.1 185-574 6159-6580 BQ185364.1 187-608 6581-11242 AC069029.9 21278-25939 c Alias Symbols: CD221, IGFIR, JTK13, MGC142170, MGC142172, MGC18216, IGFR Protein Interaction Partner: KCNIP3, UBC, ESR1, PHB2, SHC1, FBXO6, SH2B1, Slc23a3, RPL11, HSP90AA1, GRB14, FFAR2, ARRB2, AMY2A, APP, RUVBL1, GNB2L1, ARRB1, YWHAG, TP53, NEDD4, MDM2, GRB10, SUMO1, CAMP, ERBB2, EGFR, KRT27, DOK5, DOK4, WISP2, EHD1, ARHGEF12, PIK3R3, VAV3, PRKD1, SOCS2, Protein Size: 1367 |
Molecular Weight | 71 kDa |
Gene ID | 3480 |
NCBI Accession | NM_000875, NP_000866 |
UniProt | P08069 |
Pathways | RTK Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy |
Application DetailsProduct Details anti-IGF1R Antibody Target Details IGF1R Handling References for anti-IGF1R antibody (ABIN2792087) Images back to top |
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Application Notes | Optimal working dilutions should be determined experimentally by the investigator. |
Comment |
Antigen size: 1367 AA |
Restrictions | For Research Use only |
HandlingProduct Details anti-IGF1R Antibody Target Details IGF1R Application Details References for anti-IGF1R antibody (ABIN2792087) Images back to top |
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Format | Liquid |
Concentration | Lot specific |
Buffer | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose. |
Preservative | Sodium azide |
Precaution of Use | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handling Advice | Avoid repeated freeze-thaw cycles. |
Storage | -20 °C |
Storage Comment | For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. |
References for anti-IGF1R antibody (ABIN2792087)Product Details anti-IGF1R Antibody Target Details IGF1R Application Details Handling Images back to top |
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Product cited in: |
Kubota, Elalieh, Saless, Fong, Wang, Babey, Cheng, Bikle: "Insulin-like growth factor-1 receptor in mature osteoblasts is required for periosteal bone formation induced by reloading." in: Acta astronautica, Vol. 92, Issue 1, pp. 73-78, 2013 |
Background publications |
Urano, Narusawa, Shiraki, Usui, Sasaki, Hosoi, Ouchi, Nakamura, Inoue: "Association of a single nucleotide polymorphism in the insulin-like growth factor-1 receptor gene with spinal disc degeneration in postmenopausal Japanese women." in: Spine, Vol. 33, Issue 11, pp. 1256-61, 2008 |
ImagesProduct Details anti-IGF1R Antibody Target Details IGF1R Application Details Handling References for anti-IGF1R antibody (ABIN2792087) back to top |
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Supplier Images |