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anti-Human KIT Antibodies:
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the missense mutation p.Arg682His, the g.77784972T>C variant at KIT and the g.20147039C>T variant at MITF (show MITF Antibodies) are the main influence on the extent of white facial markings
Accumulating mutations in series of haplotypes at the KIT and MITF (show MITF Antibodies) loci are major determinants of white markings in Franches-Montagnes horses.
FGF7 (show FGF7 Antibodies) may be an important regulator for oocyte growth and its action is mediated via the KIT/KITLG (show KITLG Antibodies) signaling pathway.
c-kit is primarily expressed in the spermatogonia and spermatocytes of goat testes.
These results suggest that DDX4 (show DDX4 Antibodies) and c-kit are putative markers of undifferentiated spermatogonia in the prepubertal porcine testis.
mRNA expression of c-kit and SCF was decreased in gallbladder tissues in the HCD group. Consistent with the findings of RT-PCR, a lower expression level of c-kit and SCF protein was also observed in HCD animals.
Delayed enrichment for c-kit and inducing cardiac differentiation attenuated protective effects of BMSCs' transplantation in pig model of acute myocardial infarction.
Pravastatin improves function in hibernating myocardium by mobilizing CD133+ and cKit+ bone marrow progenitor cells and promoting myocytes to reenter the growth phase of the cardiac cell cycle.
current c-Kit reporter models are discussed with respect to myocardial c-Kit cell biology and function.
PKC-delta (show PKCd Antibodies) expression is associated with KIT expression and the prognosis of patients with adenoid cystic carcinomas (AdCCs), suggesting that PKC-delta (show PKCd Antibodies) may be a potential therapeutic target for AdCCs.
Study demonstrates that an oncogenic tyrosine kinase (show TXK Antibodies) mutant, KIT(D816V), can alter the transcriptional program of the transcription factor MITF (show MITF Antibodies) in melanoma.
High c-kit expression is associated with small cell lung cancer.
The expression of c-Kit under the influence of nilotinib, dasatinib, erlotinib, gefitinib and afatinib was studied in HPV-positive head and neck squamous cell carcinomas. Gefitinib significantly increased cKIT expression in HPV-positive and HPV-negative head and neck squamous cell carcinoma cells whereas nilotinib and afatinib decreased cKIT expression in HPV-positive SCC (show CYP11A1 Antibodies).
Our findings showed that increased expression of CD34 (show CD34 Antibodies) and CD117 markers confer tumor progression and aggressiveness on prostate cancer.
A phase Ib study of dasatinib plus ipilimumab in patients with gastrointestinal stromal tumor (GIST) and other sarcomas was performed on the basis of preclinical data demonstrating that combined KIT and CTLA-4 (show CTLA4 Antibodies) blockade is synergistic.
4 different mutant (MT-KIT) KIT proteins from GIST tumors are intrinsically less stable than wild-type KIT due to proteasome-mediated degradation and abnormally localized to the endoplasmic reticulum or the Golgi complex. PKC-theta (show PRKCQ Antibodies); is strongly and exclusively expressed in GISTs and interacts with intracellular MT-KIT to promote its stabilization by increased retention in the Golgi complex.
Report a new in vivo model of KIT D816V+ advanced systemic mastocytosis developed by transplantation of the human ROSAKIT D816V-Gluc (show GBA Antibodies) mast cell line in NOD-SCID (show PRKDC Antibodies) IL-2R gamma (show IL2RG Antibodies)-/- mice, using Gaussia princeps luciferase as a reporter.
KIT D816V mutation sensitized mast cells from systemic mastocytosis patients to histone deacetylase (show HDAC1 Antibodies) inhibitor mediated killing.
This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
c-kit receptor tyrosine kinase
, mast/stem cell growth factor receptor
, protein kinase
, tyrosine kinase receptor homolog
, c-kit-related protein
, kit-related kinase 1
, mast/stem cell growth factor receptor-related protein Kit
, proto-oncogene tyrosine-protein kinase Kit-related protein
, tyrosine-protein kinase Kit
, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
, Mast/stem cell growth factor receptor
, mast/stem cell growth factor receptor Kit
, transmembrane tyrosine kinase receptor
, proto-oncogene c-Kit
, c-kit receptor
, mast cell growth factor receptor
, proto-oncogene tyrosine-protein kinase Kit
, receptor tyrosine kinase c-kit
, c-KIT gene1
, Proto-oncogene c-Kit
, Tyrosine-protein kinase Kit
, caprine c-kit protein
, p145 c-kit
, piebald trait protein
, soluble KIT variant 1
, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein