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anti-Human KIT Antibodies:
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combined panel had the highest sensitivity and specificity at 96.3% and 100%, which was significantly or marginally higher than those of EZH2 (show EZH2 Antibodies), C-KIT, and CD205 (show LY75 Antibodies) alone
current c-Kit reporter models are discussed with respect to myocardial c-Kit cell biology and function.
PKC-delta (show PKCd Antibodies) expression is associated with KIT expression and the prognosis of patients with adenoid cystic carcinomas (AdCCs), suggesting that PKC-delta (show PKCd Antibodies) may be a potential therapeutic target for AdCCs.
Study demonstrates that an oncogenic tyrosine kinase (show TXK Antibodies) mutant, KIT(D816V), can alter the transcriptional program of the transcription factor MITF (show MITF Antibodies) in melanoma.
High c-kit expression is associated with small cell lung cancer.
The expression of c-Kit under the influence of nilotinib, dasatinib, erlotinib, gefitinib and afatinib was studied in HPV-positive head and neck squamous cell carcinomas. Gefitinib significantly increased cKIT expression in HPV-positive and HPV-negative head and neck squamous cell carcinoma cells whereas nilotinib and afatinib decreased cKIT expression in HPV-positive SCC (show CYP11A1 Antibodies).
Our findings showed that increased expression of CD34 (show CD34 Antibodies) and CD117 markers confer tumor progression and aggressiveness on prostate cancer.
A phase Ib study of dasatinib plus ipilimumab in patients with gastrointestinal stromal tumor (GIST) and other sarcomas was performed on the basis of preclinical data demonstrating that combined KIT and CTLA-4 (show CTLA4 Antibodies) blockade is synergistic.
4 different mutant (MT-KIT) KIT proteins from GIST tumors are intrinsically less stable than wild-type KIT due to proteasome-mediated degradation and abnormally localized to the endoplasmic reticulum or the Golgi complex. PKC-theta (show PRKCQ Antibodies); is strongly and exclusively expressed in GISTs and interacts with intracellular MT-KIT to promote its stabilization by increased retention in the Golgi complex.
Report a new in vivo model of KIT D816V+ advanced systemic mastocytosis developed by transplantation of the human ROSAKIT D816V-Gluc (show GBA Antibodies) mast cell line in NOD-SCID (show PRKDC Antibodies) IL-2R gamma (show IL2RG Antibodies)-/- mice, using Gaussia princeps luciferase as a reporter.
FGF7 (show FGF7 Antibodies) may be an important regulator for oocyte growth and its action is mediated via the KIT/KITLG (show KITLG Antibodies) signaling pathway.
These results suggest that DDX4 (show DDX4 Antibodies) and c-kit are putative markers of undifferentiated spermatogonia in the prepubertal porcine testis.
mRNA expression of c-kit and SCF was decreased in gallbladder tissues in the HCD group. Consistent with the findings of RT-PCR, a lower expression level of c-kit and SCF protein was also observed in HCD animals.
Delayed enrichment for c-kit and inducing cardiac differentiation attenuated protective effects of BMSCs' transplantation in pig model of acute myocardial infarction.
Pravastatin improves function in hibernating myocardium by mobilizing CD133+ and cKit+ bone marrow progenitor cells and promoting myocytes to reenter the growth phase of the cardiac cell cycle.
PAX3 (show PAX3 Antibodies) gene and sabino1 of KIT gene interact to create different coat color patterns
the missense mutation p.Arg682His, the g.77784972T>C variant at KIT and the g.20147039C>T variant at MITF (show MITF Antibodies) are the main influence on the extent of white facial markings
Accumulating mutations in series of haplotypes at the KIT and MITF (show MITF Antibodies) loci are major determinants of white markings in Franches-Montagnes horses.
c-kit is primarily expressed in the spermatogonia and spermatocytes of goat testes.
The expression of c-kit and beta-catenin (show CTNNB1 Antibodies) suggests that erythropoietin (show EPO Antibodies) may exert a role in regeneration reducing the extent of tubular damage from the outset after gentamicin administration.
The role of ErbB (show EGFR Antibodies) and Kit signalling in establishing melanophore stem cells in zebrafish.
The regeneration defect in kita mutants is not due to defects in melanocyte stem cells recruitment or in the proliferation, differentiation or survival of the daughter cells, but is instead due to a defect in stem cell establishment.
Kita driven expression of oncogenic HRAS (show HRAS Antibodies) leads to early onset and highly penetrant melanoma in zebrafish
Ectopic expression of foxd3 (show FOXD3 Antibodies) indicates that foxd3 (show FOXD3 Antibodies) promotes early melanophore death only when kit is inactive
This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
mast/stem cell growth factor receptor Kit
, p145 c-kit
, piebald trait protein
, proto-oncogene c-Kit
, proto-oncogene tyrosine-protein kinase Kit
, soluble KIT variant 1
, tyrosine-protein kinase Kit
, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
, c-kit-related protein
, kit-related kinase 1
, mast/stem cell growth factor receptor-related protein Kit
, proto-oncogene tyrosine-protein kinase Kit-related protein
, Mast/stem cell growth factor receptor
, c-kit receptor tyrosine kinase
, mast/stem cell growth factor receptor
, protein kinase
, c-kit receptor
, mast cell growth factor receptor
, c-KIT gene1
, receptor tyrosine kinase c-kit
, tyrosine kinase receptor homolog
, transmembrane tyrosine kinase receptor
, Proto-oncogene c-Kit
, Tyrosine-protein kinase Kit
, caprine c-kit protein
, c-kit homolog
, mast/stem cell growth factor receptor kita
, tyrosine kinase